Kugwiritsa ntchito Hydroxypropyl Methylcellulose mu Makapisozi

Hydroxypropyl Methylcellulose (HPMC) ndi polima opangidwa ndi madzi osungunuka kuchokera ku cellulose. Amagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala ngati ❖ kuyanika, binder, ndi filler mumipangidwe yamapiritsi. M'zaka zaposachedwa, HPMC yapeza kutchuka ngati kapisozi zakuthupi chifukwa cha mawonekedwe ake apadera. M'nkhaniyi, tiwona momwe HPMC imagwiritsidwira ntchito mu makapisozi.

Makapisozi a HPMC, omwe amadziwikanso kuti makapisozi amasamba, ndi m'malo mwa makapisozi a gelatin. Amapangidwa kuchokera ku HPMC, madzi, ndi zinthu zina monga carrageenan, potassium chloride, ndi titaniyamu woipa. Makapisozi a HPMC amakondedwa ndi ogula omwe amakonda moyo wamasamba kapena osadya nyama komanso omwe ali ndi zoletsa zachipembedzo kapena zachikhalidwe pakudya kwa zinthu zochokera ku nyama.

Ubwino waukulu wa makapisozi a HPMC pa makapisozi a gelatin ndi awa:

1. Kukhazikika: Makapisozi a HPMC amakhala okhazikika kuposa makapisozi a gelatin pansi pazikhalidwe zosiyanasiyana, monga chinyezi ndi kusintha kwa kutentha. Izi zimawapangitsa kukhala osankhidwa bwino pamapangidwe osakanikirana ndi chinyezi komanso hygroscopic.
2. ngakhale: HPMC n'zogwirizana ndi osiyanasiyana yogwira zosakaniza ndi excipients, kuphatikizapo acidic, zofunika, ndi ndale mankhwala. Izi zimapangitsa kukhala chisankho choyenera chamitundu yosiyanasiyana.
3. Chinyezi Chochepa: Makapisozi a HPMC amakhala ndi chinyezi chocheperako kuposa makapisozi a gelatin, omwe amachepetsa chiopsezo cha kukula kwa tizilombo tating'onoting'ono ndikuwonjezera moyo wa alumali wazinthu.
4. Kusungunuka: Makapisozi a HPMC amasungunuka mofulumira komanso mofanana m'matumbo a m'mimba, kupereka kumasulidwa kosasintha komanso kosayembekezereka kwa chinthu chogwira ntchito.

Kugwiritsa ntchito HPMC mu makapisozi ndi motere:

1. Makapisozi Zipolopolo: HPMC ntchito monga pophika chachikulu pakupanga HPMC kapisozi zipolopolo. Njirayi imaphatikizapo kusakaniza kwa HPMC, madzi, ndi zosakaniza zina kuti apange yankho la viscous. Njira yothetsera vutoli imatulutsidwa muzitsulo zazitali, zomwe zimadulidwa mu utali wofunidwa ndi mawonekedwe. Zipolopolo za kapisozi zimagwirizanitsidwa pamodzi kuti zikhale kapisozi wathunthu.

Makapisozi a HPMC akupezeka mumitundu yosiyanasiyana, mitundu, ndi mawonekedwe, kuphatikiza kuzungulira, chowulungika, ndi oblong. Athanso kusindikizidwa ndi ma logo, zolemba, ndi zolembera zina pazolinga zamtundu.

2. Mapangidwe Otulutsidwa Oyendetsedwa: Makapisozi a HPMC amagwiritsidwa ntchito kwambiri popanga zotulutsa zoyendetsedwa bwino chifukwa cha kuthekera kwawo kusungunuka mwachangu komanso mofanana m'matumbo am'mimba. Mlingo wa kumasulidwa ukhoza kuwongoleredwa pogwiritsa ntchito magulu osiyanasiyana a HPMC okhala ndi ma viscosity osiyanasiyana komanso kulemera kwa maselo. Mlingo wotulutsidwa ungathenso kuwongoleredwa mwa kusintha makulidwe a chipolopolo cha kapisozi ndi kukula kwa kapisozi.
3. Kulawa Kupaka masking: HPMC makapisozi angagwiritsidwe ntchito kulawa masking zowawa kapena zosasangalatsa Kulawa mankhwala. Zomwe zimagwiritsidwa ntchito zimayikidwa mkati mwa chipolopolo cha HPMC kapisozi, kuteteza kukhudzana mwachindunji ndi zokometsera. Chipolopolo cha kapisozi cha HPMC chimathanso kuphimbidwa ndi zinthu zina zopaka zokometsera monga ma polima kapena lipids kuti apititse patsogolo kukoma kokoma.
4. Kupaka kwa Enteric: Makapisozi a HPMC atha kugwiritsidwa ntchito popaka mapiritsi kapena ma pellets kuti awateteze ku asidi am'mimba ndikuwongolera kutulutsidwa kwazomwe zimagwira m'matumbo aang'ono. Chipolopolo cha kapisozi cha HPMC chimakutidwa ndi polima yotchedwa enteric polima, yomwe imasungunuka pa pH ya 6 kapena kupitilira apo, kuwonetsetsa kuti zomwe zimagwira zimatulutsidwa m'matumbo aang'ono.
5. Mapiritsi: Makapisozi a HPMC atha kugwiritsidwa ntchito kuyika ma pellets kapena mapiritsi ang'onoang'ono, kupereka mawonekedwe osavuta komanso osinthika a mlingo. Ma pellets amakutidwa ndi wosanjikiza wa HPMC kuti asamamatirane ndikuwonetsetsa kuti amamasulidwa chimodzimodzi kuchokera ku kapisozi.

Pomaliza, Hydroxypropyl Methylcellulose (HPMC) ndi zinthu zosunthika zomwe zatchuka kwambiri ngati kapisozi chifukwa cha mawonekedwe ake apadera.