Kugwiritsa ntchito HPMC pokonzekera

1 monga zinthu zokutira filimu ndi zinthu zopangira filimu

Kugwiritsa ntchito hypromellose (HPMC) ngati piritsi lophimbidwa ndi filimu, poyerekeza ndi mapiritsi ophimbidwa achikhalidwe monga mapiritsi okhala ndi shuga, mapiritsi okhala ndi shuga alibe zabwino zodziwikiratu pakubisa kukoma kwamankhwala ndi mawonekedwe, koma kuuma kwawo ndi kukhazikika kwawo, kuyamwa kwa chinyezi, kupasuka, ❖ kuyanika kulemera ndi zizindikiro zina khalidwe bwino. Gulu lochepa la viscosity la mankhwalawa limagwiritsidwa ntchito ngati filimu yosungunuka yamadzi yosungunuka pamapiritsi ndi mapiritsi, ndipo gulu lapamwamba la viscosity limagwiritsidwa ntchito ngati filimu yopangira mafilimu opangira organic zosungunulira. Nthawi zambiri zimakhala 2.0% mpaka 20%.

2 monga chomangira ndi disintegrant

Kalasi yotsika kwambiri ya mankhwalawa imatha kugwiritsidwa ntchito ngati chomangira komanso chosokoneza pamapiritsi, mapiritsi, ndi ma granules, ndipo kalasi yapamwamba kwambiri ingagwiritsidwe ntchito ngati chomangira. Mlingo umasiyanasiyana ndi mitundu yosiyanasiyana ndi zofunika. Nthawi zambiri, mlingo wa binder pamapiritsi owuma a granulation ndi 5%, ndipo mlingo wa binder pamapiritsi a granulation wonyowa ndi 2%.

3 ngati woyimitsa

Kuyimitsa wothandizila ndi viscous gel osakaniza mankhwala ndi hydrophilicity, amene akhoza kuchepetsa sedimentation liwiro la particles pamene ntchito suspending wothandizira, ndipo akhoza Ufumuyo pamwamba pa particles kuteteza particles kuti aggregating ndi kugwa mu mpira. . Oyimitsa ntchito amagwira ntchito yofunika kwambiri poyimitsa. HPMC ndi zabwino kwambiri zosiyanasiyana suspending wothandizira, ndi kusungunuka colloidal njira akhoza kuchepetsa mavuto a madzi olimba mawonekedwe ndi ufulu mphamvu pa tinthu tating'ono olimba, potero utithandize bata la sakanikira kubalalitsidwa dongosolo. The mkulu-makamaka mamasukidwe kalasi kalasi ya mankhwala ntchito ngati kuyimitsidwa-mtundu wa madzi kukonzekera kukonzekera monga suspending wothandizira. Zili ndi ubwino woyimitsa, ndizosavuta kufalitsanso, sizimamatira pakhoma, ndipo zimakhala ndi particles zabwino. Mlingo wamba ndi 0.5% mpaka 1.5%.

4 ngati chotchinga, chotulutsa chokhazikika komanso choyambitsa pore

Mapiritsi a hydrophilic gel matrix omwe amatulutsidwa mosalekeza, otsekereza ndi owongolera omwe amamasulidwa pamapiritsi osakanikirana a matrix osakanikirana, ndipo amakhala ndi zotsatira zochedwetsa kutulutsidwa kwa mankhwala. Kugwiritsa ntchito kwake ndi 10% ~ 80% (W / W). Makalasi otsika-kukhuthala amagwiritsidwa ntchito ngati pore-forming agents pokonzekera kumasulidwa kosalekeza kapena kumasulidwa kolamuliridwa. Koyamba mlingo chofunika achire zotsatira za mtundu uwu wa piritsi chingapezeke mwamsanga, ndiyeno kupitiriza kumasulidwa kapena ankalamulira kumasulidwa tingati, ndi ogwira magazi mankhwala ndende anakhalabe mu thupi . Hypromellose ikakumana ndi madzi, imalowa m'madzi kuti ikhale wosanjikiza wa gel. Njira yotulutsa mankhwala kuchokera papiritsi ya matrix makamaka imaphatikizapo kufalikira kwa gel osanjikiza ndi kukokoloka kwa gel osanjikiza.

5 monga thickener ndi colloidal zoteteza guluu

Izi zikagwiritsidwa ntchito ngati thickener, ndende yomwe imagwiritsidwa ntchito kwambiri ndi 0.45% ~ 1.0%. Izi mankhwala akhoza kuonjezera bata wa guluu hydrophobic, kupanga colloid zoteteza, kuteteza particles kuchokera agglomerating ndi agglomerating, potero inhibiting mapangidwe matope, ndi ndende yake mwachizolowezi ndi 0,5% ~ 1.5%.

6 ngati kapisozi zakuthupi

Nthawi zambiri kapisozi chipolopolo kapisozi zakuthupi kapisozi zachokera gelatin. Kapangidwe ka chipolopolo cha gelatin kapisozi ndi kophweka, koma pali mavuto ndi zochitika zina monga chitetezo chochepa ku chinyezi ndi mankhwala okhudzidwa ndi okosijeni, kutsika kwa mankhwala osokoneza bongo, komanso kuchedwa kutha kwa chipolopolo cha kapisozi panthawi yosungira. Choncho, hypromellose, m'malo mwa makapisozi gelatin, ntchito yokonza makapisozi, amene bwino formability ndi ntchito zotsatira za makapisozi, ndipo wakhala ankalimbikitsa kwambiri kunyumba ndi kunja.

7 ngati bioadhesive

Ukadaulo wa bioadhesion, kugwiritsa ntchito ma polima okhala ndi bioadhesive polima, kudzera kumamatira ku mucosa wachilengedwe, kumawonjezera kupitiliza ndi kulimba kwa kulumikizana pakati pa kukonzekera ndi mucous membrane, kotero kuti mankhwalawa amamasulidwa pang'onopang'ono ndikumwedwa ndi mucosa kuti akwaniritse zolinga zachirengedwe. Pakali pano amagwiritsidwa ntchito pochiza matenda a m'mphuno, m'kamwa mucosa ndi mbali zina. Tekinoloje ya m'mimba ya bioadhesion ndi njira yatsopano yoperekera mankhwala yomwe idapangidwa zaka zaposachedwa. Sikuti prolongs okhala nthawi ya mankhwala kukonzekera mu m`mimba thirakiti, komanso bwino kukhudzana ntchito pakati pa mankhwala ndi selo nembanemba pa mayamwidwe malo, kusintha fluidity wa selo nembanemba, Kupititsa patsogolo malowedwe a mankhwala kwa m`mimba. maselo a epithelial, potero kusintha bioavailability wa mankhwala.

8 ngati gel osakaniza

Monga zomatira zokonzekera khungu, gel osakaniza ali ndi mndandanda wa ubwino monga chitetezo, kukongola, kuyeretsa kosavuta, mtengo wotsika, njira yosavuta yokonzekera, komanso kugwirizana bwino ndi mankhwala. malangizo.

9 monga sedimentation inhibitor mu emulsification system