Kedu ihe bụ ihe na-emetụta viscosity na transmictylthylthylthylthylthylthylthylthylthylthylthylthylthylthylthylthylthylthylthyl

Hydroxypylththththththylcelllose (hpmc)A na-ejikarị polymer polymer na-ejikarị ya na-emepụta ọgwụ, nhazi nri, owuwu, ihe owuwu, ihe owuwu, ihe owuwu, ihe ịchọ mma na ubi ndị ọzọ. Njirimara anụ ahụ, viscosity na transmict, nwere mmetụta dị mkpa na arụmọrụ ngwa ya.

1.
Ibu molecular bụ otu n'ime ihe dị mkpa na-ekpebi arụmọrụ nke HPMC. Dika oke molecular nke Kimacell®hing® na-abawanye, akwara dilka na-abawanye na viscosis nke ihe ngwọta na-abawanye. Nke a bụ n'ihi na ọ dị ogologo oge nwere ike mmekọrịta dị ike na ihe ngwọta ahụ, na-ebute mmiri dị mma, nke gosipụtara dị ka viocosity dị elu. N'ụzọ dị iche, ngwọta HPMC nwere oke molecular nwere oke mmiri na-enweghị isi na obere viscosity.

Igo molecular nwekwara mmekọrịta na mbu. N'ikwu okwu, azịza HPMC nwere oke molecular nwere ike mepụta usoro agglomeration site na ụdọ molecular, nke na-emetụta mbelata nke ọkụ ma na-eduga na mbelata.

2. Hydroxypropyyl na ogo methylation
Ọdịmma kemịkalụ nke Hpmc gụnyere otu hydroxyl na Methyy, na ngosipụta nke ìgwè ndị a na-emetụta oke mmụọ ya, viscosiseths, viscosiseSTosince ya. N'ikwu okwu, na-abawanye ogo hydroxylation nwere ike ime ka ogo nke hpmc, mgbe ị na-abawanye ogo nke methylation nwere ike inye aka dịkwuo elu ma nọgide na-akwụsị iche nke colloid.

Ogo nke methylation: mmụba dị na ogo nke methylition ga-eduga mmụba na mmekọrịta dị n'etiti ụmụ irighiri ihe ngwọta. Oke dị elu nke methylation nwere ike ibute viscosity nke ihe ngwọta ibu oke, na-emetụta ọnya.
Ogo nke Hydroxyyyyyyyyyyyyyyy: Inye ihe na-eme ihe hydroxyy na-abawanye hydrophy nke ụmụ irighiri mmiri, na-eme ka ịghazi nke HPMC, ma na-enyere aka iji usoro collaid dị ike karị. Oke dị elu nke hydropopyyyọl nwere ike belata nghọta nke ihe ngwọta ahụ, si otú ahụ na-emetụta ụtụ.

3. Njirimara Njirimara
Njirimara nke HPMC na viscosity nke ihe ngwọta na-emetụta nke mgbaze. N'ozuzu, HPMC nwere ike gbatịrị na mmiri, mana ihe na-eme ka ihe dị ka okpomọkụ dịka okpomọkụ, uru nke mmiri.

Ọnọdụ okpomọkụ: Atumatumatutuotumatutuoniture na-enyere aka hpmc igbari ma belata viscosity nke ihe ngwọta. Agbanyeghị, ọ bụrụ na ọnọdụ okpomọkụ dị oke elu, ọ nwere ike ibute HPMC, na-emetụta ọhụụ ya na nbugharị ya.
PHT bara uru: solublity na vissiosis nke HPMC metụtakwara nke HPMC. Ngwọta na viscosity nke HPMC nwere ike ịdị iche na ụkpụrụ plọg plọk, karịchaa na ọnụnọ elu nke acid ma ọ bụ alkali, ebe ngụgụ na viscosity nke HPMC nwere ike ibelata ma ọ bụ mụbaa.
Mgbakwunye ionic ike: Ọ bụrụ na agbakwunye nnu nnu na ngwọta, ike ionic nke ihe ngwọta na-abawanye, nke nwere ike imetụta mmekọrịta n'etiti ụmụ irighiri ihe ma si otú ahụ gbanwere viscosity.

4. Nleba anya HPMC
Nụrụ nke HPMC nwere mmetụta na-arụ ọrụ na viscosity nke ihe ngwọta. N'ikwu okwu n'ozuzu, viscosity nke ihe ngwọta na-abawanye na mmụba na ntinye aka HPMC. Agbanyeghị, n'ọdụ ahụ dị elu, ihe ngwọta nwere ike iru ogo viscosise, nke na-akọwa mmetụta nke ịba ụba ịba ụba nke viscosity ga-esighi ike.

Mmụba anya nwere ike imetụta nghọta nke HPMC Ngwọta. Ihe ngwọta dị elu nwere ike itolite irighiri ma ọ bụ nchịkọta n'ihi mmekọrịta siri ike n'etiti ụmụ irighiri mmiri, nke na-ebute ịgbasa ọkụ ma na-emetụta mgbanwe.

5. Achịcha Shear na History
Ahụhụ na nza nke Kimagell®hpmc ngwọta na-emetụta ụfọdụ site na ọnụego oke mmiri (ya bụ, ọnụego) na akụkọ ihe mere eme shaar. Nke dị elu na-atụ ọnụego ya, sie ike mmiri nke ihe ngwọta na ala na viscosity. Ogologo oge na-eme mkpọtụ nwere ike iduga na mmebi nke akwara, na-emetụta viscosit na tractiventance nke ngwọta.

Sheee akụkọ nwere nnukwu mmetụta na omume Rhimc nke HPMC Ngwọta. Ọ bụrụ na a ga-emebi ihe ngwọta ogologo oge, enwere ike ibibi usoro ụmụ irighiri Hpmc, nke na-ebute mbelata na viscosity, ma nwekwara ike imetụta mbugharị.

6. Ihe mgbakwunye mpụga

Na HPMC Ngwọta, na-agbakwunye ụdị mgbakwunye dị iche iche (dịka ndị dị iche iche, ndị na-ekwu okwu, nnu, wdg) ga-emetụta ya viccositse na nbugharị ya. Dịka ọmụmaatụ, ụfọdụ ndị na-emekọrịta ihe nwere ike imekọrịta HPMC iji mepụta ụdị, si na-abawanye viscosity nke ihe ngwọta. Na mgbakwunye, mgbakwunye nke ụfọdụ nnu nwere ike imekwuo nhazi mgbanwe na viscosity nke hpmc site na ịgbanwe ike ionic site na ngwọta nke ihe ngwọta.

Ndị dị egwu: Ihe mgbakwunye ndị a na-abawanye na-abụkarị ihe ngwọta nke HPMC Ngwọta, mana iji oke nwere ike ime ihe ga - eme ka ị ga --eweta ụdị viocosisse.

Surfactants: Mgbakwunye nke Surfacans nwere ike melite nkwụsi ike nke ngwọta HPMC, mana ọ nwekwara ike ịgbanwe ụtụ ya, n'ihi na ụmụ irighiri ihe nwere ike imekọrịta ihe na-enweghị mgbasa nke ọkụ.

7. Ọnọdụ nchekwa nke ihe ngwọta

Ọnọdụ nchekwa nke Kimacell®hpmc Ngwọta nwekwara mmetụta dị mkpa na viscosity na ndọgha. Nchekwa ogologo oge nwere ike ibute mgbanwe na viscosis nke HPMC Ngwọta, ọkachasị na gburugburu ọnọdụ ma ọ bụ ọkụ siri ike. Nnukwu okpomọkụ ma ọ bụ mkpocha ogologo ma ọ bụ ìhè ogologo oge na ọkụ ultraviolet nwere ike ibute nrụrụ nke HPMC, na-emetụta viscosity nke ihe ngwọta wee meekwa ka mgbanwe na transminance.

Viscosity na transmict nkeHpmcỌtụtụ ihe na-emetụta ọtụtụ ihe, tumadi gụnyere oke molecular, ogo hydroxylyl, akụrụngwa, ịta, ihe mgbakwunye mpụga, na ọnọdụ nchekwa nke ihe ngwọta. Site na ezi uche na-edozigharị ihe ndị a, ihe ngwọta HPMC nwere ihe ụfọdụ enwere ike ịme ka ọ dị mkpa iji merie mkpa nke ngwa dị iche iche.