Ihe ndị na-emetụta viscosity nke hydroxypropyl methylcellulose

Hydroxyl methyl cellulose (HPMC) bụ polymer a na-ejikarị eme ihe na ọgwụ, ihe ịchọ mma, nri na ụlọ ọrụ ndị ọzọ. Njirimara ya pụrụ iche, dị ka viscosity dị elu, ezigbo mmiri -soluble na ike ịmepụta akpụkpọ ahụ, na-eme ka ọ bụrụ ihe dị mkpa na usoro dị iche iche. The viscosity bụ isi ihe nke HPMC na ngwa ya. Ihe dị iche iche na-emetụta viscosity HPMC, dị ka itinye uche, okpomọkụ, pH, na arọ molekụla. Ịghọta ihe ndị na-emetụta viscosity HPMC dị mkpa maka njikarịcha. Isiokwu a na-atụle ihe ndị na-emetụta viscosity nke hydroxylopyl methyl cellulose.

Gbado anya na

Ntinye nke HPMC bụ otu n'ime isi ihe na-emetụta viscosity ya. Viscosity nke ngwọta HPMC na-abawanye na mmụba nke itinye uche. N'ebe dị ala, a na-ekesa yinye polymer HPMC na ihe mgbaze, ya mere viscosity dị ala. Otú ọ dị, na ntinye uche dị elu, ụdọ polymer na-emekọrịta ihe na ibe ya, na-eme ka viscosity dị elu. Ya mere, viscosity nke HPMC kwekọrọ na ntinye nke polymer. Ntinye uche na-emetụtakwa omume gelization nke HPMC. HPMC dị elu nwere ike ịmepụta gel, nke dị ezigbo mkpa na ụlọ ọrụ ọgwụ na nri.

okpomọkụ

Okpomọkụ bụ isi ihe ọzọ na-emetụta viscosity nke hydroxylopenyl cellulose. Viscosity HPMC na-ebelata site na mmụba okpomọkụ. Yinye polymer HPMC na-abawanye na oke okpomọkụ, na-ebute viscosity dị ala. E jiri ya tụnyere ngwọta ntinye uche dị elu, mmetụta nke okpomọkụ na viscosity HPMC na-apụta ìhè na ngwọta ntinye uche dị ala. Mmụba nke okpomọkụ ga-emetụtakwa solubility nke HPMC. N'ebe okpomọkụ dị elu, solubility nke HPMC na-ebelata, na-ebute mbelata nke viscosity kpatara site na mbelata nke njikọ yinye.

pH

The pH nke HPMC ngwọta bụ ihe ọzọ dị mkpa na-emetụta ya viscosity. HPMC bụ polymer acidic na-adịghị ike, yana PKA nke ihe dịka 3.5. Ya mere, viscosity nke HPMC ngwọta na-enwe mmetụta na pH nke ngwọta. N'okpuru uru pH dị elu karịa PKA, otu nnu carboxylic acid nke polymer nọ n'okpuru protonization, nke mere ka solubility nke HPMC mụbaa, na viscosity belatara n'ihi mbelata nke njikọ hydrogen nke interconsiscence molecular. N'okpuru uru pH dị n'okpuru PKA, otu carboxylic acid nke polymer bụ oke, nke kpatara obere solubility na nnukwu viscosity kpatara site na mmụba hydrogen. Ya mere, uru pH kacha mma nke ngwọta HPMC dabere na ngwa a tụrụ anya ya.

Ibu molekụla

Arọ molikula HPMC bụ ihe ọzọ dị mkpa na-emetụta viscosity ya. HPMC bụ polymer polymer. Ka ịdị arọ molekụla nke polymer na-abawanye, viscosity nke ngwọta HPMC ga-abawanye. Nke a bụ n'ihi na yinye HPMC dị arọ molekul na-ekekọta karịa, na-ebute mmụba viscosity. The molekụla arọ nke polima na-emetụta HPMC gelization. Polymer HPMC yikarịrị ka ọ ga-etolite gels karịa polymer arọ molekụla dị ala.

Nnu

Ịtinye nnu na ngwọta HPMC nwere ike imetụta viscosity ya nke ọma. Nnu na-emetụta ike ion nke ngwọta HPMC, nke na-agbanwe mmekọrịta nke polymers. N'ozuzu, ịgbakwunye nnu na ngwọta HPMC ga-eme ka viscosity belata. Nke a bụ n'ihi na ike ion nke ngwọta na-ebelata n'etiti ike molekụla n'etiti HPMC polymer chain, si otú a na-ebelata mbelata nke njikọ yinye, ya mere viscosity na-ebelata. Mmetụta nke nnu na viscosity nke ngwọta HPMC dabere na ụdị na ntinye nke nnu.

na ngwụcha

Viscosity nke hydroxydal cibolin bụ isi ihe na-emetụta ngwa ya na ụlọ ọrụ dị iche iche. Ihe na-emetụta viscosity HPMC gụnyere itinye uche, okpomọkụ, pH, arọ molecular na nnu. Ịghọta ihe ndị a na viscosity HPMC dị mkpa iji bulie ojiji ya na ngwa dị iche iche. Enwere ike gbanwee ngwọta HPMC nke ọma iji nweta viscosity achọrọ nke akọwapụtara.