Ngwa nke Hydroxypropyl Methylcellulose na Capsules

Hydroxypropyl Methylcellulose (HPMC) bụ sịntetik, polymer soluble mmiri nke sitere na cellulose. A na-ejikarị ya na ụlọ ọrụ na-emepụta ọgwụ dị ka onye na-ekpuchi ihe, ihe nkedo, na ihe nkpuchi na mbadamba mbadamba. N'afọ ndị na-adịbeghị anya, HPMC enwetala ewu ewu dị ka ihe capsule n'ihi njirimara pụrụ iche ya. N'isiokwu a, anyị ga-enyocha ngwa nke HPMC na capsules.

Capsules HPMC, nke a makwaara dị ka capsules onye anaghị eri anụ, bụ ihe ọzọ na capsules gelatin. A na-eme ha site na HPMC, mmiri, na ihe ndị ọzọ dị ka carrageenan, potassium chloride, na titanium dioxide. Ndị na-azụ ahịa na-ahọrọ ụdị anụ anaghị eri anụ ma ọ bụ anụ anaghị eri anụ na ndị nwere mmachi okpukperechi ma ọ bụ omenala na oriri ngwaahịa sitere n'anụmanụ na-ahọrọ capsules HPMC.

Isi uru nke capsules HPMC karịa capsules gelatin bụ:

1. Nkwụsi ike: Capsules HPMC kwụsiri ike karịa capsules gelatin n'okpuru ọnọdụ dị iche iche, dị ka iru mmiri na mgbanwe okpomọkụ. Nke a na-eme ka ha bụrụ ezigbo nhọrọ maka nhazi mmiri na-enwe mmetụta na hygroscopic.
2. Ndakọrịta: HPMC dakọtara na ọtụtụ ihe na-arụ ọrụ na ihe mgbakwunye, gụnyere acidic, isi na ọgwụ na-anọpụ iche. Nke a na-eme ka ọ bụrụ ezigbo nhọrọ maka nhazi dị iche iche.
3. Ọdịnaya Ọdịnaya dị ala: Capsules HPMC nwere obere mmiri dị ala karịa capsules gelatin, nke na-ebelata ohere nke uto microbial ma gbatịa ndụ shelf nke ngwaahịa ahụ.
4. Mgbasa: Capsules HPMC na-agbaze ngwa ngwa na otu n'otu n'ime traktị eriri afọ, na-enye ntọhapụ na-agbanwe agbanwe na nke a na-ahụ anya nke ihe na-arụ ọrụ.

Ngwa nke HPMC na capsules bụ nke a:

1. Shell Capsule: A na-eji HPMC eme ihe dị ka isi ihe na-emepụta shei capsule HPMC. Usoro a gụnyere ịgwakọta HPMC, mmiri, na ihe ndị ọzọ iji mepụta ngwọta viscous. A na-ewepụ ihe ngwọta ahụ n'ime ogologo eriri ogologo, nke a na-egbutu n'ime ogologo na ọdịdị a chọrọ. A na-ejikọta shells capsule ọnụ ka ha wee mepụta capsule zuru oke.

Capsules HPMC dị n'ụdị, agba na ụdị dị iche iche, gụnyere okirikiri, oval na oblong. Enwere ike iji akara ngosi, ederede na akara ndị ọzọ bipụta ha maka ebumnuche akara.

2. Ụdị mwepụta a na-achịkwa: A na-ejikarị capsules HPMC eme ihe n'ụdị mwepụta a na-achịkwa n'ihi ike ha na-agbaze ngwa ngwa na otu n'ime eriri afọ. Enwere ike ịchịkwa ọnụego ntọhapụ site na iji akara ule dị iche iche nke HPMC nwere ogo viscosity dị iche iche na ịdị arọ molekụla. Enwere ike ịchịkwa ọnụego ntọhapụ site n'ịgbanwe nha nke shei capsule na nha capsule ahụ.
3. Ikpuchi ire ụtọ: Enwere ike iji capsules HPMC mee ihe iji kpuchie uto nke ọgwụ ụtọ ilu ma ọ bụ nke na-adịghị mma. A na-etinye ihe na-arụ ọrụ n'ime shei capsule HPMC, na-egbochi kọntaktị ozugbo na ihe ụtọ. A nwekwara ike kpuchie shei capsule HPMC na ihe ndị ọzọ na-eme ihe na-atọ ụtọ dị ka polymers ma ọ bụ lipids iji welie ụtọ nkpuchi.
4. Ihe mkpuchi ihe: Enwere ike iji HPMC capsules maka mkpuchi enteric nke mbadamba nkume ma ọ bụ pellets iji chebe ha pụọ ​​​​na acid gastric na iji kwado mwepụta nke ihe na-arụ ọrụ na eriri afọ. A na-ekpuchi shei capsule HPMC na polymer enteric, nke na-agbaze na pH nke 6 ma ọ bụ karịa, na-ahụ na a na-ahapụ ihe na-arụ ọrụ n'ime eriri afọ.
5. Pellets: Enwere ike iji capsules HPMC kpuchie pellets ma ọ bụ mbadamba obere, na-enye ụdị usoro onunu ogwu na-adaba adaba na mgbanwe. A na-ekpuchi pellets na oyi akwa HPMC iji gbochie ha ịrapara ọnụ yana hụ na a na-ewepụta ha n'otu n'otu na capsule.

N'ikpeazụ, Hydroxypropyl Methylcellulose (HPMC) bụ ihe na-agbanwe agbanwe nke nwetarala ewu ewu dị ka ihe capsule n'ihi njirimara ya pụrụ iche.