IHydroxypropyl methylcellulose (HPMC) iyisisetshenziswa se-polymer evamise ukusetshenziswa ekulungiseleleni imithi.Ngenxa yezakhiwo zayo ezinhle kakhulu zomzimba namakhemikhali, idlala indima ebalulekile ekukhiqizeni amaphilisi.I-HPMC ingasetshenziswa njengefilimu yangaphambili, i-ejenti yokukhululwa elawulwayo, i-adhesive, thickener, njll., ukunikeza amaphilisi isakhiwo esihle nokusebenza okuhle.
1. Ifilimu yangaphambili
Iqhaza le-HPMC njengefilimu yangaphambili ibonakala ikakhulukazi ekuhlanganisweni okungaphezulu kwamaphilisi okukhishwa okulawulwayo.Ukugcotshwa kwethebhulethi kwenziwa ngenhloso yokulawula izinga lokukhululwa kwezidakamizwa, ukuvikela izidakamizwa emathonyeni emvelo, nokwenza ngcono ukubukeka kwezidakamizwa.Emalungiselelweni okukhishwa okulawulwayo, ifilimu eyakhiwe yi-HPMC ingalungisa izinga lokukhululwa kwezidakamizwa, iqinisekise ukuthi izidakamizwa zikhishwa ezingxenyeni ezithile zepheshana lamathumbu, futhi ifinyelele umphumela wokwelapha ongcono kakhulu.
Indlela yokwenza: Ifilimu elakhiwe ifilimu ye-HPMC yangaphambili ingafinyelela ukukhululwa okulawulwayo kwezidakamizwa ngokulawula ukufakwa kwezinyibilikisi kanye nokuqedwa kwezidakamizwa.Ugqinsi nokwakheka kwefilimu kungalungisa izinga lokuqedwa ukuze kuhlangatshezwane nezidingo zokukhishwa kwemithi ehlukene.
Umthelela: Amaphilisi asebenzisa i-HPMC njenge-ejenti eyenza ifilimu angancibilika kancane esiswini, agweme ukukhululwa kwezidakamizwa kungazelelwe, athuthukise ukusetshenziswa kwezidakamizwa, futhi ehlise ukucasuka kwezidakamizwa emgudwini wamathumbu.
2. I-ejenti yokukhululwa elawulwayo
I-HPMC ivamise ukusetshenziswa njengokubalulekile kwe-matrix kumathebulethi akhishwayo okulawulwayo ukuze kuqondiswe izinga lokukhululwa kwezidakamizwa ngokwenza umgoqo wejeli.Iqhaza le-ejenti yokukhishwa okulawulwayo ukuqinisekisa ukuthi umuthi ukhishwa ngokulinganayo phakathi nesikhathi esithile ukuze kugcinwe ukugxiliswa okusebenzayo komuthi emzimbeni, ukunciphisa inani lezikhathi zomthamo, nokuthuthukisa ukuthobela kwesiguli.
Indlela yokwenza: Kumithombo yezindaba enamanzi, i-HPMC ingakwazi ukuthela amanzi ngokushesha futhi yakhe isakhiwo senethiwekhi ye-colloidal, elawula ukusakazeka kanye nezinga lokukhululwa komuthi.Uma ithebhulethi ihlangana namanzi, i-HPMC imunca amanzi futhi ikhukhumale yakhe ungqimba lwejeli, lapho umuthi usakazeka khona ngaphandle komzimba, futhi izinga lokukhululwa lincike ekugqimeni nasekumineni kongqimba lwejeli.
Umthelela: I-HPMC njenge-ejenti ekhishwayo elawulwayo ingazinzisa izinga lokukhululwa kwezidakamizwa, inciphise ukushintshashintsha kokugxiliswa kwezidakamizwa egazini, futhi inikeze umphumela wokwelapha ozinzile, ikakhulukazi wemithi yokwelapha izifo ezingelapheki.
3. Izibophezelo
Enqubweni yokulungiselela amaphilisi, i-HPMC ivame ukusetshenziswa njengesibophezelo ukuze kuthuthukiswe amandla emishini yamaphilisi kanye nokuqinisekisa ubuqotho bamaphilisi ngesikhathi sokugcinwa, ukuthutha kanye nokuphathwa.
Indlela yokwenza: I-HPMC, njengesibophezelo, ingakha isibopho esiqinile phakathi kwezinhlayiya, ukuze izimpushana noma izinhlayiya zihlanganiswe futhi zakheke zibe ithebhulethi eqinile.Le nqubo ivame ukwenziwa ngobuchwepheshe be-granulation obumanzi, lapho i-HPMC incibilika khona esixazululweni esinamanzi ukuze yakhe isixazululo se-viscous, futhi yakha ithebhulethi ezinzile ngemva kokoma.
Umthelela: Izibophezelo ze-HPMC zingathuthukisa amandla acindezelayo nobulukhuni bamathebulethi, zehlise ingcuphe yokuhlakazeka noma ukuhlukana, futhi ngaleyo ndlela zithuthukise ikhwalithi nokuzinza kwamaphilisi.
4. Izikhukhula
I-HPMC ingasetshenziswa futhi njenge-thickener ekulungiseleleni uketshezi ukulungisa izakhiwo ze-rheological zamalungiselelo nokwandisa i-viscosity.
Indlela yokwenza: I-HPMC ine-viscosity ephezulu emanzini futhi ingakhuphula ngempumelelo i-viscosity yoketshezi, ithuthukise ukumiswa nokuzinza komuthi, futhi ivimbele ukuvela kwenhlabathi.
Umthelela: Ukwengeza i-HPMC emithini ewuketshezi kungathuthukisa ukufana komuthi, kwenze izingxenye zomuthi zisatshalaliswe ngokulinganayo kuwo wonke amalungiselelo, futhi kuqinisekise umthamo ongashintshi isikhathi ngasinye.
Izici ze-Hydroxypropyl Methylcellulose
1. Izakhiwo Zomzimba Nezamakhemikhali
I-HPMC i-nonionic cellulose ether enokuncibilika okuhle kwamanzi kanye ne-thermal gelation.Incibilika ngokushesha emanzini abandayo ukuze yakhe isixazululo esisobala, kuyilapho lapho ishisa, isisombululo siphenduka ijeli.
2. I-Biocompatibility
I-HPMC ine-biocompatibility enhle nokuphepha, futhi ayijwayele ukubanga ukusabela kwamasosha omzimba noma imiphumela enobuthi, ngakho-ke isetshenziswa kakhulu emikhakheni yezemithi nokudla.
3. Ukuzinza kwemvelo
I-HPMC inokuqina okuhle ezicini zemvelo ezifana nezinga lokushisa kanye nenani le-pH, futhi ayithambekele ekucekeleni phansi noma ekushintshanisweni kwe-denaturation, okuqinisekisa ukuzinza kwamalungiselelo ezidakamizwa ngesikhathi sokugcinwa.
Izibonelo zohlelo lwe-HPMC kumathebulethi
1. Amaphilisi Okukhishwa Okulawulwayo
Isibonelo, kumaphilisi e-nifedipine akhishwa ngokuqhubekayo asetshenziselwa ukwelapha umfutho wegazi ophakeme, i-HPMC isetshenziswa njengento ye-matrix ukulawula ukukhululwa kancane komuthi, ukunciphisa imvamisa yokuphatha, nokuthuthukisa ukuthobela isiguli.
2. Amaphilisi ane-Enteric-coated
Kumaphilisi anamekwe nge-enteric e-proton pump inhibitors (njenge-omeprazole), i-HPMC isebenza njenge-ejenti eyenza ifilimu ukuze ivikele umuthi ekubhujisweni yi-asidi yesisu futhi iqinisekise ukuthi umuthi ukhishwa ngempumelelo emathunjini.
3. Amaphilisi omlomo ancibilika ngokushesha
Kumaphilisi omlomo ancibilika ngokushesha okwelapha i-rhinitis engezwani ne-rhinitis, i-HPMC isebenza njenge-thickener ne-adhesive ukuze inikeze ukuqedwa okusheshayo nokukhululwa okufanayo, ukuthuthukisa ukunambitheka kanye nokuthatha isipiliyoni somuthi.
IHydroxypropyl methylcellulose isetshenziswa kakhulu ekulungiseni amaphilisi ahlukahlukene ngenxa yokwakheka kwawo okuhle kwefilimu, ukukhululwa okulawulwayo, ukunamathela nokujiya.I-HPMC ayikwazi nje ukuthuthukisa izakhiwo zomzimba nokuzinza kwamaphilisi, kodwa futhi ithuthukise umphumela wokwelapha wezidakamizwa ngokulungisa izinga lokukhululwa kwezidakamizwa.Ngokuthuthukiswa kobuchwepheshe bezemithi, ukusetshenziswa kwe-HPMC kuzohlukahluka kakhulu, kunikeze amathuba amaningi okwenziwa okusha kwamalungiselelo emithi.
Isikhathi sokuthumela: Jun-27-2024