Uyini umehluko phakathi kwe-hydroxypropyll methylcellulose (HPMC) nge noma ngaphandle s?

I-Hydroxypropyl methylcellulose (HPMC)i-cellulose derivative esetshenziswa kabanzi kwizimboni zezemithi, zokudla, zamakhemikhali nezokwakha. Isakhiwo saso samakhemikhali siqukethe amaqembu e-hydroxypropyl kanye ne-methyls, futhi imisebenzi yaso eyinhloko injenge-gelling, i-ejenti ye-gelling, ehlakazekile, njll. Ekuqanjululwe kwe-Kimacell®hpmpmc, umehluko phakathi kokuthi i-SAL "S" empeleni imele imininingwane ehlukile nezakhiwo.

1. Okushiwo yi-HPMC nama-HPMCS

Umehluko omkhulu phakathi kwe-HPMC nama-HPMCS ukuthi i- "S" egameni laye lagcina imele iqembu "leSulfate", okungukuthi, kwezinye izikhathi, ama-HPMC Derivatives azokwengeza amaqembu ama-sulfate ukwandisa ukusebenza kwawo okuthile.

I-HPMC: Leli yi-hydroxypropprosel ejwayelekile, engekho amaqembu we-sulfate. Isetshenziswa kakhulu ekudleni, umuthi, izimonyo, ukwakhiwa kanye nezinye izinkambu, futhi inezakhiwo eziyisisekelo njengokuqina, ukwakha amafilimu, nokuhlakazeka. I-HPMC iyinhlanganisela ye-hydroxypropyl kanye namaqembu we-methyl, kanye nokubonakala kwawo, ukuSolubelity kanye Rheology kungalawulwa ngokulungisa ama-degree ahlukene wokuthelwa.

Ama-HPMCS: I-HPMCS yi-hydroxypropyllllypropyll methylcellulose sulfate equkethe amaqembu we-sulfate. I- "S" imele inqubo yokuhlaselwa, evame ukwenza into i-hydrophilic eyengeziwe, futhi ukuqina nokubonakala kusixazululo kungahluka. Ama-HPMCS ajwayele ukusetshenziswa ezimweni ezidinga ukuqina okuphezulu nokuvuselelwa kwamakhemikhali athile, njengenkambu yezemithi.

2. Umehluko wesakhiwo samakhemikhali

Isakhiwo samakhemikhali se-HPMC ikakhulukazi sisuselwa ku-cellulose, eguqulwa yi-methylation kanye ne-hydroxypropylication. Isakhiwo saso sinamanzi aphezulu amanzi futhi singakha isixazululo se-colloidal emanzini.

Ukwakheka kwamakhemikhali ama-HPMCS kususelwa ku-HPMC ngokungeniswa kwamaqembu we-sulfate, okuguqula i-hydrophicility yayo nokusebenza kwezixazululo ezithile zamanzi. Ukwethulwa kwamaqembu we-sulfate kusiza ukukhulisa i-hydration yayo futhi kungathinta izinga lokuchithwa kwalo noma izakhiwo ze-rheological ngaphansi kwezimo ezithile.

3. Ukuhlukahluka kokusebenza

I-Solubinity: I-HPMC ivame ukuncibilika emanzini ukwakha isixazululo esibonakalayo futhi inokulungiswa okuhle kwendlela. I-solubility yayo nokubonakala kungashintshwa njengoba kudingeka, njengokulawula ubumbano bayo ngamanzi nezindawo ezimboziwe ezitsheni ezibonisiwe.

Ukuqina: Ama-HPMCS akhuphule i-hydrophicity ngenxa yokwethulwa kwamaqembu we-sulfate, anganikeza ukuqina okungcono kwemikhiqizo ethile yemithi noma yezimonyo. Ngaphezu kwalokho, amaqembu we-sulfate angenza futhi ama-kimacell®HPCS azinze ngaphansi kwezimo ezithile, njengokuswakama okuphezulu noma ukuguqula amanani e-PH, lapho ama-HPMC angakhombisa ukubekezelela okunamandla.

I-BioCOMTIBIL: Njenge-Execipieint ye-Pharmaceutical esetshenziswa kabanzi, i-HPMC iqinisekiswe ngokuphelele ngokuqiniseka kwayo nokuphepha emkhakheni wezemithi. Kodwa-ke, ngenxa yokwengezwa kwamaqembu we-sulfate, ama-HPMC angadinga izifundo ezengeziwe zobuthi kwezinye izinhlelo ezibucayi.

4. Izinkambu zohlelo lokusebenza

I-HPMC: isetshenziswe kabanzi emithi yemithi (efana nezidakamizwa ezisetshenziselwa amathebhulethi, izimbotshana zethebhulethi), izimonyo, ukwakhiwa, ukudla nezinye izimboni. Ukungabi nobuthi bakhe, i-hypoallergenenicicity kanye nokuqina okuphezulu kwenza kube mkhulu ojwayelekile, ifilimu langaphambili kanye ne-stibilizer kwizimboni zokudla kanye nokudla.

Ama-HPMCS: Ngenxa yezakhiwo zayo zamakhemikhali ezikhethekile kanye nezimpawu zokulululwa, ama-HPMC asetshenziswa kakhulu kwezinye izinhlelo ezifunwa ngokwemiba, ikakhulukazi ukulungiswa kwezidakamizwa ezikhululiwe. Ama-HPMCS ajwayele ukusetshenziswa kuma-ejenti asetshenziselwa izidakamizwa nezinhlelo ezithile zokulethwa kwezidakamizwa, futhi kwesinye isikhathi asetshenziswa ezithakeni zokudla.

I-5. Ukucaciswa komkhiqizo okujwayelekile

I-HPMC nama-HPMCS anezinhlobonhlobo zemikhiqizo ehlukahlukene, ezivame ukuhlukaniswa ngokuya ngamapharamitha anjengesisindo se-molecular, izinga lokuthezeka, kanye ne-solubity. Imikhiqizo yokucaciswa okuhlukile izokhombisa ukusebenza okuhlukile kwizicelo ezihlukile.

I-HPMC inamazinga ahlukene okuthezeka, ama-viscosities ahlukile kanye nama-sonibip, futhi alungele izinkambu ezahlukene. Ukucaciswa okujwayelekile kufaka i-viscosity ephansi, ukubonakala okuphakathi, ukubonakala okuphezulu, njll.

Ukucaciswa kwama-HPMCS ikakhulukazi ahlukaniswe ngokwezingqinamba ezinjengezinga le-sulfation, i-solubity kanye ne-hydrophilicity. Ama-HPMCS okucaciswa okuhlukile angashintshwa ngokuya ngezidingo ezahlukene zokwakhiwa kwezidakamizwa.

I-HPMC nama-HPMCS anomehluko omkhulu ekwakhiweni kwamakhemikhali, izindawo zokusebenza kanye nezinsizakusebenza. I-HPMC iyi-hydroxcellulose ejwayelekile, esetshenziswa kabanzi emikhakheni eminingi; Ngenkathi i-HPMCS iyi-kimacell®PHPCC ephakeme, ene-hydrophicility ephakeme kanye nokusebenza okuthize, futhi isetshenziswa ikakhulukazi emikhakheni yobungcweti edinga ukuqina okuphezulu, njengokukhishwa kwezidakamizwa okuqhubekayo.

Ekusetshenzisweni kwangempela, ukukhethwa kweI-HPMCnoma ama-HPMC anqunywe ngokuya ngezidingo ezithile kanye nezicelo. Uma kunezidingo ezikhethekile ze-solubity, ukuqina, njll., Ama-HPMCs anganikezwa kuqala. Uma kungekho zimfuneko eziphakeme kakhulu zezindleko nokusebenza, i-HPMC ingukukhetha okuvame kakhulu futhi okunomnotho.