I-HPMC (Hydroxypropyl Methylcellulose) iyinto esebenza ngokusebenza esetshenziswa kabanzi ekudleni kwemithi, ekudleni, izinto zokwakha kanye nezinye izinkambu. Imikhiqizo ye-HPMC ingahlukaniswa ibe uchungechunge oluningi ngokuya ngezidingo zohlelo lokusebenza ezahlukahlukene, phakathi kwalapho zivame kakhulu zinguchungechunge lwe-K uchungechunge. Yize zombili ziyi-HPMC, zinokwehluka okuqondile kwesakhiwo samakhemikhali, izakhiwo zemvelo kanye nezinkundla zohlelo lokusebenza.
1. Umehluko ngesakhiwo samakhemikhali
Okuqukethwe methoxy: Umehluko omkhulu phakathi kwe-K Series ne-E Series HPMC okuqukethwe kwabo kwe-methoxy. Okuqukethwe kwe-methoxy kwe-E Series HPMC kuphakeme (ngokuvamile 28-30%), kanti okuqukethwe kwe-methoxy kochungechunge kuphansi (cishe ngo-19-24%).
Okuqukethwe kwe-Hydroxypropoxy: Ngokuphambene, okuqukethwe kwe-hydroxypropoxy kochungechunge lwe-K (7-12%) kuphakeme kunalokho kwe-E (4-7.5%). Lo mehluko ekubumbeni kwamakhemikhali kuholela ekwehlukahluka ekusebenzeni nasekusetshenzisweni phakathi kwalokhu okubili.
2. Umehluko ezintweni ezibonakalayo
I-Solubinity: Ngenxa yomehluko kokuqukethwe kwe-methoxy kanye ne-hydroxypropoxy, i-solubity ye-K Series HPMC iphansi kakhulu kunaleyo yochungechunge lwe-E, ikakhulukazi emanzini abandayo. Uchungechunge lwe-E lunyibilika kakhulu emanzini abandayo ngenxa yokuqukethwe kwalo okuphezulu kwe-methoxy.
Ukushisa kwe-GEL: Izinga lokushisa le-gel le-K Series liphakeme kunalolo chungechunge. Lokhu kusho ukuthi ngaphansi kwezimo ezifanayo, kuba nzima ngokwengeziwe ku-K uchungechunge lwe-KPMC ukuze wakhe ijeli. Izinga lokushisa le-gel likachungechunge lwe-E liphansi, nakwezinye izinhlelo ezithile, njengezinto zokwenziwa ze-gel, uchungechunge lwe-eCher lungasenza kangcono.
I-Viscosity: Yize i-Viscosity ikakhulukazi incike esimeni samangqamuzana se-HPMC, ngaphansi kwezimo ezifanayo, i-viscosity ye-E Series HPMC ivame kakhulu ukwedlula leyo uchungechunge lwe-K. Umehluko ekubonakaleni unomthelela omkhulu kwizakhiwo zesimbobo ngesikhathi senqubo yokulungiselela, ikakhulukazi uma ufakwa ekubonweni nasekumisweni.
3. Umehluko ezinhlelweni zohlelo lokusebenza
Ngenxa yokwehluka kokwakheka kwamakhemikhali kanye nezindawo ezibonakalayo zochungechunge lwe-K nochungechunge lwe-HPMC, izinhlelo zazo ezinkambisweni ezihlukile zihlukile.
Inkambu yezemithi: Amalungiselelo emithi, u-E Series HPMC uvame ukusetshenziswa njengezithako eziphambili zokulungiswa okudedelwa okuqhubekayo. Lokhu kungenxa yokushisa kwayo okuphansi kwe-gelature kanye nokuvunywa okuphezulu, okukuvumela ukuthi kulawule kangcono izinga lokukhishwa kwezidakamizwa lapho kwakheka ifilimu elisekela izidakamizwa. Uchungechunge lwe-K lusetshenziselwa amaphilisi ahlanganiswe ngaphakathi kanye nanjenge-capsule wall impahla, ngoba izinga lokushisa layo eliphakeme livimbela ukukhishwa kwezidakamizwa ku-gastric jusi, okulungele ukukhishwa kwezidakamizwa emathunjini.
Inkambu yokudla: Embonini yokudla, i-E Series HPMC ivame ukusetshenziswa njenge-smighter, stabilizer kanye ne-emulsifier. Ngenxa ye-solubility yayo ephezulu nokubonakala okufanele, kungahlakazeka kangcono futhi kuchithwe ekudleni. Uchungechunge lwe-K lusetshenziswa kakhulu ekudleni okudinga ukulondolozwa ukuzinza ngaphansi kwezimo zokushisa okuphezulu, njengemikhiqizo ephekiwe, ngenxa yokushisa kwayo okuphezulu kwe-gelation.
Inkambu Yezinto Zokwakha: Ezintweni zokwakha, i-K Series HPMC ivame ukusetshenziswa ku-data womuntu omile kanye ne-putty powder, esebenza njengomgcini wamanzi futhi ikakhulukazi, ikakhulukazi izikhathi ezidinga ukwakhiwa emazingeni okushisa aphezulu. Uchungechunge lwe-E lufaneleke ngokwengeziwe izinto ezinezinto eziphakeme ze-rheological ezifana nopende waphansi kanye nezimbobo ngenxa yokushisa kwayo okuphansi kwe-gelation nokuvunywa okuphezulu.
4. Ezinye izinto ezinethonya
Ngaphezu kwalokho umehluko ongenhla, ukusetshenziswa okuthile kochungechunge oluhlukile lwe-HPMC kungathinta nezinto ezifana nesisindo se-molecular, izinga lokufaka esikhundleni. Ngaphezu kwalokho, kuzinhlelo zokusebenza ezisebenzayo, ukukhethwa kwe-HPMC nakho kudinga ukubheka ukuhambisana kwako nezinye izithako kanye nomthelela wayo ekusebenzeni komkhiqizo wokugcina.
Yize uchungechunge lwe-K nochungechunge lwe-HPMC luzo zombili i-hydroxypropyllllylyllylyllylylylylylylylylylylylylylylylylylylylylylylylylyllose, zibonisa umehluko osobala ezindaweni ezibonakalayo kanye nezindawo zohlelo lokusebenza ngenxa yamaqembu ahlukile amaqembu we-methoxy ne-hydroxypropopoxy. Ukuqonda lo mehluko kubalulekile ekukhetheni uhlobo lwe-HPMC olusebenzayo ngezicelo ezisebenzayo.
Isikhathi sePosi: Aug-13-2024