I-HPMC (i-Hydroxypropyl Methylcellulose) iyimpahla enemisebenzi eminingi esetshenziswa kabanzi kwezemithi, ukudla, izinto zokwakha kanye neminye imikhakha. Imikhiqizo ye-HPMC ingahlukaniswa ngochungechunge oluningi ngokuya ngezidingo ezihlukene zohlelo lokusebenza, phakathi kwazo ezivame kakhulu uchungechunge lwe-K nochungechunge luka-E. Nakuba zombili ziyi-HPMC, zinomehluko othile ekwakhekeni kwamakhemikhali, izakhiwo ezingokomzimba nezinkambu zokufaka isicelo.
1. Umehluko ekwakhekeni kwamakhemikhali
Okuqukethwe kwe-Methoxy: Umehluko omkhulu phakathi kochungechunge lwe-K no-E uchungechunge lwe-HPMC okuqukethwe kwazo kwe-methoxy. Okuqukethwe kwe-methoxy kochungechunge lwe-E HPMC kuphezulu (ngokuvamile 28-30%), kuyilapho okuqukethwe kwe-methoxy kochungechunge lwe-K kuphansi kakhulu (cishe u-19-24%).
Okuqukethwe kwe-Hydroxypropoxy: Ngokuphambene, okuqukethwe kwe-hydroxypropoxy kochungechunge lwe-K (7-12%) kungaphezulu kwalokho kochungechunge lwe-E (4-7.5%). Lo mehluko ekubunjweni kwamakhemikhali uholela ekuhlukeni ekusebenzeni nasekusetshenzisweni phakathi kokubili.
2. Umehluko ezintweni ezibonakalayo
Ukunyibilika: Ngenxa yomehluko kokuqukethwe kwe-methoxy ne-hydroxypropoxy, ukunyibilika kochungechunge lwe-K lwe-HPMC kungaphansi kancane kunochungechunge luka-E, ikakhulukazi emanzini abandayo. Uchungechunge luka-E luncibilika kakhulu emanzini abandayo ngenxa yokuqukethwe kwalo okuphezulu kwe-methoxy.
Izinga lokushisa lejeli: Izinga lokushisa lejeli lochungechunge lwe-K liphakeme kunalelo lochungechunge luka-E. Lokhu kusho ukuthi ngaphansi kwezimo ezifanayo, kuba nzima kakhulu ochungechungeni lwe-K HPMC ukwenza ijeli. Izinga lokushisa lejeli lochungechunge luka-E liphansi, futhi kwezinye izinhlelo zokusebenza ezithile, njengezinto zejeli ezishisayo, uchungechunge lwe-E lungenza kangcono.
I-Viscosity: Nakuba i-viscosity incike kakhulu esisindweni samangqamuzana e-HPMC, ngaphansi kwezimo ezifanayo, i-viscosity yochungechunge lwe-E HPMC ngokuvamile iphakeme kunaleyo yochungechunge lwe-K. Umehluko we-viscosity unomthelela omkhulu ezakhini ze-rheological ngesikhathi senqubo yokulungiselela, ikakhulukazi uma isetshenziselwa ukumboza nokumiswa.
3. Umehluko emikhakheni yezicelo
Ngenxa yomehluko wesakhiwo samakhemikhali nezakhiwo ezibonakalayo zochungechunge lwe-K nochungechunge lwe-E HPMC, ukusetshenziswa kwazo emikhakheni ehlukene nakho kuhlukile.
Inkundla yezemithi: Emalungiselweni emithi, uchungechunge lwe-E HPMC luvame ukusetshenziswa njengesithako esiyinhloko samalungiselelo okukhishwa okuqhubekayo. Lokhu kungenxa yokushisa kwayo okuphansi kwe-gelation kanye ne-viscosity ephezulu, okuyenza ikwazi ukulawula kangcono izinga lokukhishwa kwezidakamizwa lapho kwakhiwa ifilimu ekhishwa njalo yesidakamizwa. Uchungechunge lwe-K lusetshenziselwa kakhulu amaphilisi ane-enteric-coated futhi njenge-capsule wall material, ngoba izinga lokushisa eliphezulu le-gelation livimbela ukukhululwa kwezidakamizwa kujusi yesisu, okulungele ukukhululwa kwezidakamizwa emathunjini.
Inkundla yokudla: Embonini yokudla, uchungechunge lwe-E HPMC luvame ukusetshenziswa njenge-thickener, stabilizer kanye ne-emulsifier. Ngenxa yokuncibilika kwayo okuphezulu kanye ne-viscosity efanelekile, ingahlakazeka kangcono futhi incibilike ekudleni. Uchungechunge lwe-K lusetshenziswa kakhulu ekudleni okudinga ukugcina ukuzinza ngaphansi kwezimo zokushisa eziphezulu, njengemikhiqizo ebhakiwe, ngenxa yokushisa kwayo okuphezulu kwe-gelation.
Inkambu yezinto zokwakha: Ezintweni zokwakha, uchungechunge lwe-K lwe-HPMC luvame ukusetshenziswa odakeni olomile kanye nempushana ye-putty, esebenza njengesigcini samanzi nesijiya, ikakhulukazi ngezikhathi ezidinga ukwakhiwa emazingeni okushisa aphezulu. Uchungechunge lwe-E lufaneleka kakhulu ezintweni ezinezakhiwo eziphezulu ze-rheological ezifana nopende wephansi kanye nezingubo ngenxa yokushisa okuphansi kwe-gelation kanye ne-viscosity ephezulu.
4. Ezinye izici ezinethonya
Ngokungeziwe kulo mehluko ongenhla, ukusetshenziswa okuqondile kochungechunge oluhlukile lwe-HPMC kungase futhi kuthintwe izici ezifana nesisindo samangqamuzana, izinga lokushintsha, kanye nokuhlakazeka. Ngaphezu kwalokho, ekusetshenzisweni okungokoqobo, ukukhethwa kwe-HPMC nakho kudinga ukucabangela ukuhambisana kwayo nezinye izithako kanye nomthelela wayo ekusebenzeni komkhiqizo wokugcina.
Nakuba uchungechunge lwe-K kanye nochungechunge lwe-E lwe-HPMC kokubili kuyi-hydroxypropyl methylcellulose, abonisa umehluko osobala ezindaweni ezibonakalayo nasezindaweni ezisetshenziswayo ngenxa yokuqukethwe okuhlukile kwamaqembu e-methoxy ne-hydroxypropoxy. Ukuqonda lo mehluko kubalulekile ekukhetheni uhlobo olulungile lwe-HPMC ezinhlelweni zokusebenza.
Isikhathi sokuthumela: Aug-13-2024