Ubudlelwano phakathi kokubonakala kwe-HPMC kanye nokushisa kanye nokuphepha

I-HPMC (HYDROXYPROPYL Methylcellulose) iyinto esetshenziswa kakhulu yekhaminye esetshenziselwa ukukhiqizwa kwezinhlobonhlobo zezindlela ezahlukahlukene zamadoma amakhemikhali, kufaka phakathi amaphilisi, amaphilisi, kanye nemikhiqizo ye-ophthalmic. Enye yezinto ezibalulekile ze-HPMC ukubonwa kwayo, okuthinta izakhiwo zomkhiqizo wokugcina. Le ndatshana izohlola ubudlelwano phakathi kokuvunywa kwe-HPMC kanye nokushisa bese igqamisa ezinye izinyathelo zokuphepha okufanele zithathwe lapho usebenzisa le-excipient.

Ubudlelwano phakathi kokubonakala kwe-HPMC kanye nokushisa

I-HPMC iyi-polymer ye-hydrophilic enyakazisa emanzini nakwezinye izixazululo ze-polar. Lapho i-HPMC ichithwa emanzini, yakha isixazululo se-viscous ngenxa yesisindo esiphakeme se-polymer kanye ne-hydrophility. I-viscosity yezixazululo ze-HPMC ithintwa yizici eziningana, kufaka phakathi ukufinyeleleka kwe-polymer, izinga lokushisa lesisombululo, kanye ne-pH ye-solvent.

Enye yezinto ezibalulekile ezithinta ukubonwa kwesixazululo se-HPMC izinga lokushisa. I-viscosity yezixazululo ze-HPMC inciphisa ngokushisa okuphezulu. Lokhu kungenxa yokuthi emazingeni okushisa aphezulu, amaketanga e-polymer abe uketshezi oluningi, okuholela ekutheni amabutho ambalwa wenhlamvu ebambe amaketanga e-polymer ndawonye. Ngenxa yalokhu, ukubonakala kwesixazululo kuyancipha futhi uketshezi lwesixazululo luyakhuphuka.

Ubudlelwano phakathi kokushisa kanye ne-HPMC viscosisisisisision bungachazwa yi-arrhenius equation. I-Arrhenius equation i-equation yezibalo echaza ubudlelwano phakathi kwesilinganiso sokusabela kwamakhemikhali kanye nokushisa kohlelo. Ngezixazululo ze-HPMC, i-Arrhenius equation ingasetshenziswa ukuchaza ubudlelwano phakathi kokuvunywa kwesisombululo kanye nokushisa kohlelo.

I-Arrhenius equation inikezwa ngu:

k = ae ^ (- EA / RT)

Lapho k i-rate njalo, i-factor yangaphambi kwe-exponential, i-EA ingamandla okwenza igesi, futhi i-t izinga lokushisa lohlelo. I-viscosity yezixazululo ze-HPMC ihlobene ne-Flow Rate ye-solvent nge-polymer matrix, elawulwa yimigomo efanayo nesilinganiso sokuphendula kwamakhemikhali. Ngakho-ke, i-Arrhenius equation ingasetshenziswa ukuchaza ubudlelwano phakathi kokuvunywa kwesixazululo kanye nokushisa kohlelo.

Izinto okufanele uphawule lapho usebenzisa i-HPMC

Lapho usebenza ne-HPMC, kufanele kuthathwe izinyathelo ezimbalwa zokuqapha ukuze kuqinisekiswe ukuphathwa okuphephile nokusebenzayo kwe-polymer. Lezi zindlela zokuphepha zifaka:

1. Sebenzisa imishini yokuvikela

Kubalulekile ukusebenzisa imishini yokuvikela efana namagilavu, ama-goggles, kanye namajazi welebhu lapho uphatha i-HPMC. Lokhu kungenxa yokuthi i-HPMC ingacasula isikhumba namehlo, futhi ingadala izinkinga zokuphefumula uma i-inhalid. Ngakho-ke, kubalulekile ukuthatha izinyathelo zokunciphisa ubungozi bokuchayeka kuma-polymers.

2. Gcina i-HPMC kahle

I-HPMC kufanele igcinwe endaweni epholile, eyomile ukuvikela ukumuncwa komswakama emoyeni. Lokhu kungenxa yokuthi i-HPMC i-hygroscopic, okusho ukuthi ithola umswakama endaweni yayo ezungezile. Uma i-HPMC ithatha umswakama omningi kakhulu, ingathinta i-viscosity kanye nezakhiwo zomkhiqizo wokugcina.

3. Nakisisa ukugxila kanye lokushisa

Lapho uqala nge-HPMC, qiniseka ukuthi unaka ukugxila nokushisa kwesisombululo. Lokhu kungenxa yokuthi i-viscosity yezixazululo ze-HPMC inqunywa kakhulu ngalezi zinto. Uma ukugxila noma izinga lokushisa liphezulu kakhulu noma liphansi kakhulu, lizothinta i-viscosity kanye nezakhiwo zomkhiqizo wokugcina.

4. Sebenzisa izindlela ezifanele zokucubungula

Lapho ucubungula i-HPMC, kubalulekile ukusebenzisa izindlela ezifanele zokucubungula ukuqinisekisa ukuphathwa okuphephile nokusebenzayo kwe-polymer. Lokhu kungafaka ukusebenzisa izindlela zokuxuba okuphansi okuphansi ukuvikela ukuchezula kwe-polymer noma ukuwohloka, noma ukusebenzisa amasu afanele ukumiswa ukususa umswakama owedlulele kumkhiqizo wokugcina.

5. Isheke ukuhambisana

Uma usebenzisa i-HPMC njenge-excipient, kubalulekile ukubheka ukuhambisana namanye ama-excipie nezithako ezisebenzayo ekwakhekeni. Lokhu kungenxa yokuthi i-HPMC ingasebenzisana nezinye izithako ekwakhekeni, okuthinta ukusebenza nokuqina komkhiqizo wokugcina. Ngakho-ke, kubalulekile ukwenza izifundo zokuhambisana ukukhomba noma yiziphi izingqinamba ezingaba khona ngaphambi kokuqhubeka nokwakhiwa.

Ekuphetheni

I-viscosity yezixazululo ze-HPMC ithintwa yizici eziningana, kufaka phakathi ukugxila, izinga lokushisa kanye no-pH. I-viscosity yezixazululo ze-HPMC incipha ngokunwebeka lokushisa ngenxa yokuhamba okwengeziwe kwamaketanga we-polymer. Lapho usebenza ne-HPMC, kubalulekile ukuthatha izinyathelo zokuphepha ezifanele ukuqinisekisa ukuphathwa okuphephile nokusebenzayo kwe-polymer. Lezi zindlela zokuphepha zibandakanya ukusebenzisa imishini yokuvikela, ngokugcina kahle i-HPMC, ukunaka izinga lokuhlushwa kanye nokushisa, kusetshenziswa izindlela zokucubungula ezifanele, nokubheka ukuhambisana nezinye izithako kufomula. Ngokuthatha lezi zinyathelo zokuphepha, i-HPMC ingasetshenziswa njengendlela ephumelelayo ye-expeapient kumafomu ahlukahlukene emithi emithi.