I-HPMC (i-hydroxypropyl methylcellulose) iyisakhi semithi esetshenziswa kakhulu esetshenziswa ekukhiqizeni amafomu emithamo eyehlukene yemithamo, okuhlanganisa amaphilisi, amaphilisi, kanye nemikhiqizo yamehlo. Enye yezinto ezibalulekile ze-HPMC yi-viscosity yayo, ethinta izakhiwo zomkhiqizo wokugcina. Lesi sihloko sizohlola ubudlelwano phakathi kwe-HPMC viscosity nezinga lokushisa futhi sigqamise ezinye izinyathelo zokuphepha okufanele zithathwe lapho kusetshenziswa lesi sisetshenziswa.
Ubudlelwano phakathi kwe-HPMC viscosity nezinga lokushisa
I-HPMC iyi-polymer eyi-hydrophilic encibilika emanzini nakwezinye izincibilikisi ze-polar. Uma i-HPMC incibilika emanzini, yenza isixazululo se-viscous ngenxa yesisindo se-polymer ephezulu yamangqamuzana kanye nezinga eliphezulu le-hydrophilicity. I-viscosity yezixazululo ze-HPMC ithintwa yizici ezimbalwa, okuhlanganisa ukugxila kwe-polymer, izinga lokushisa lesixazululo, ne-pH yesincibilikisi.
Esinye sezici ezibalulekile ezithinta i-viscosity yesisombululo se-HPMC izinga lokushisa. I-viscosity yezixazululo ze-HPMC iyancipha ngokukhuphuka kwezinga lokushisa. Lokhu kungenxa yokuthi emazingeni okushisa aphakeme, amaketanga e-polymer aba uketshezi kakhulu, okuholela ekutheni kube namandla ambalwa e-intermolecular abambe amaketanga e-polymer ndawonye. Ngenxa yalokho, i-viscosity yesisombululo iyancipha futhi i-fluidity yesisombululo iyanda.
Ubudlelwano phakathi kwezinga lokushisa kanye ne-viscosity ye-HPMC bungachazwa nge-equation ye-Arrhenius. I-Arrhenius equation isibalo sezibalo esichaza ubudlelwano phakathi kwezinga lokusabela kwamakhemikhali nezinga lokushisa lesistimu. Ngezixazululo ze-HPMC, i-Arrhenius equation ingasetshenziswa ukuchaza ubudlelwano phakathi kwe-viscosity yesixazululo nezinga lokushisa lesistimu.
I-Arrhenius equation inikezwa ngu:
k = Ae^(-Ea/RT)
lapho u-k eyisilinganiso esingaguquki, u-A uyisici sangaphambilini, i-Ea ingamandla okusebenza, u-R igesi engashintshi, futhi u-T izinga lokushisa lesistimu. I-viscosity yezixazululo ze-HPMC ihlobene nezinga lokugeleza kwe-solvent ngokusebenzisa i-polymer matrix, elawulwa isimiso esifanayo nezinga lokusabela kwamakhemikhali. Ngakho-ke, i-equation ye-Arrhenius ingasetshenziswa ukuchaza ubuhlobo phakathi kwe-viscosity yesisombululo kanye nokushisa kwesistimu.
Izinto okufanele uziqaphele lapho usebenzisa i-HPMC
Lapho usebenza ne-HPMC, kufanele kuthathwe izinyathelo ezimbalwa zokuqapha ukuze kuqinisekiswe ukuphathwa okuphephile nokusebenza kahle kwe-polymer. Lezi zinyathelo zokuphepha zihlanganisa:
1. Sebenzisa izinto zokuzivikela
Kubalulekile ukusebenzisa okokuvikela okufana namagilavu, izibuko, namajazi elebhu lapho uphatha i-HPMC. Lokhu kungenxa yokuthi i-HPMC ingacasula isikhumba namehlo, futhi ingabangela izinkinga zokuphefumula uma ihogeliwe. Ngakho-ke, kubalulekile ukuthatha izinyathelo zokunciphisa ubungozi bokuchayeka kuma-polymers.
2. Londoloza i-HPMC ngendlela efanele
I-HPMC kufanele igcinwe endaweni epholile, neyomile ukuvimbela ukumuncwa komswakamo emoyeni. Lokhu kungenxa yokuthi i-HPMC iyi-hygroscopic, okusho ukuthi imunca umswakama endaweni eyizungezile. Uma i-HPMC idonsa umswakama omningi, ingathinta i-viscosity kanye nezakhiwo zomkhiqizo wokugcina.
3. Naka ukugxilisa ingqondo nezinga lokushisa
Uma wenza nge-HPMC, qiniseka ukuthi unaka ukugxila kanye nezinga lokushisa lesixazululo. Lokhu kungenxa yokuthi i-viscosity yezixazululo ze-HPMC inqunywa kakhulu yilezi zici. Uma ukugxila noma izinga lokushisa liphezulu kakhulu noma liphansi kakhulu, kuzothinta i-viscosity kanye nezakhiwo zomkhiqizo wokugcina.
4. Sebenzisa izindlela ezifanele zokucubungula
Lapho ucubungula i-HPMC, kubalulekile ukusebenzisa izindlela zokucubungula ezifanele ukuze kuqinisekiswe ukuphathwa okuphephile nokusebenza kahle kwe-polymer. Lokhu kungase kuhlanganise ukusebenzisa izindlela zokuhlanganisa i-low-shear ukuvimbela ukugunda kwe-polymer noma ukuwohloka, noma ukusebenzisa amasu afanele okomisa ukuze kukhishwe umswakama owedlulele emkhiqizweni wokugcina.
5. Hlola ukuhambisana
Uma usebenzisa i-HPMC njenge-excipient, kubalulekile ukuhlola ukuhambisana nezinye izinto ezisizayo kanye nezithako ezisebenzayo ekwakhiweni. Lokhu kungenxa yokuthi i-HPMC ingasebenzisana nezinye izithako ekwakhiweni, okuthinta ukusebenza nokuzinza komkhiqizo wokugcina. Ngakho-ke, kubalulekile ukwenza izifundo zokuhambisana ukuze kutholakale noma yiziphi izinkinga ezingase zibe khona ngaphambi kokuqhubeka nokwakhiwa.
Ekuphetheni
I-viscosity yezixazululo ze-HPMC ithintwa izinto ezimbalwa, okuhlanganisa ukugxilisa ingqondo, izinga lokushisa, kanye ne-pH. I-viscosity yezixazululo ze-HPMC iyancipha ngokukhuphuka kwezinga lokushisa ngenxa yokwanda kokuhamba kwamaketanga e-polymer. Lapho usebenza ne-HPMC, kubalulekile ukuthatha izinyathelo zokuphepha ezifanele ukuze kuqinisekiswe ukuphathwa okuphephile nokusebenza kahle kwe-polymer. Lezi zinyathelo zokuphepha zihlanganisa ukusebenzisa izinto zokuzivikela, ukugcina kahle i-HPMC, ukunaka ukugxilisa ingqondo nezinga lokushisa, ukusebenzisa izindlela zokucubungula ezifanele, nokuhlola ukuhambisana nezinye izithako kufomula. Ngokuthatha lezi zinyathelo zokuphepha, i-HPMC ingasetshenziswa njengesamukeli esisebenzayo kumafomu emithamo eyehlukene yemithamo.
Isikhathi sokuthumela: Sep-25-2023