Indlela Yokukhiqiza Yesigaba Soketshezi Lokukhiqiza I-Hydroxypropyl Methyl Cellulose (HPMC)

IHydroxypropyl methyl cellulose (HPMC) iyi-ether cellulose esetshenziswa kakhulu ezimbonini nasezikhemisi ezisetshenziswayo ngenxa yezakhiwo zayo ezinhle kakhulu zomzimba namakhemikhali. I-HPMC ivamise ukukhiqizwa ngezindlela ezahlukahlukene, okuhlanganisa indlela yokukhiqiza yesigaba soketshezi.

Indlela yokukhiqiza yesigaba samanzi iyinqubo yokusabela kwamakhemikhali ehlanganisa ukusabela kwe-methyl cellulose (MC) nge-propylene oxide (PO) bese kuba ne-propylene glycol (PG) ngaphansi kwezimo ezithile. Inqubo ibandakanya lezi zinyathelo ezilandelayo:

1. Ukulungiswa kwe-Methyl Cellulose (MC)

I-MC itholakala ngokwelapha i-cellulose nge-alkali bese i-methylating nge-methyl chloride. Izinga lokushintshwa (DS) le-MC linquma izici zayo futhi lingalawulwa ngokushintsha izimo zokusabela.

2. Ukulungiswa kwePropylene Oxide (PO)

I-PO ilungiswa yi-oxidation ye-propylene isebenzisa umoya noma umoya-mpilo phambi kwe-catalyst. Ukusabela kwenziwa emazingeni okushisa aphezulu kanye nezingcindezi zokuqinisekisa isivuno esikhulu se-PO.

3. Ukusabela kwe-MC nge-PO

Ukusabela kwe-MC nge-PO kwenziwa phambi kwe-catalyst kanye ne-solvent efana ne-toluene noma i-dichloromethane. Ukusabela kuyi-exothermic futhi kukhiqiza ukushisa, okumele kulawulwe ukuze kugwenywe ukusabela okubalekayo.

4. Ukulungiswa kwePropylene Glycol (PG)

I-PG ilungiswa yi-hydrolysis ye-propylene oxide kusetshenziswa amanzi noma i-asidi efanelekile noma i-base catalyst. Ukusabela kwenziwa ngaphansi kwezimo ezithambile ukuze kutholwe isivuno esikhulu se-PG.

5. Ukusabela kwe-MC-PO nge-PG

Umkhiqizo we-MC-PO ube ususabela nge-PG ebukhoneni be-catalyst nesincibilikisi esifana ne-ethanol noma i-methanol. Ukusabela kuphinde kube ne-exothermic futhi kukhiqiza ukushisa, okumele kulawulwe ukuze kugwenywe ukusabela kokubaleka.

6. Ukuwasha nokomisa

Ngemuva kokusabela, umkhiqizo ugezwa ngamanzi futhi womiswe ukuze uthole i-HPMC. Umkhiqizo uvamise ukuhlanzwa kusetshenziswa uchungechunge lwezinyathelo zokuhlunga kanye ne-centrifugation ukususa noma yikuphi ukungcola.

Indlela yokukhiqiza yesigaba se-liquid inezinzuzo ezimbalwa kunezinye izindlela, okuhlanganisa isivuno esiphezulu, izindleko eziphansi, kanye nokulinganisa okulula. Ukusabela kungenziwa emkhunjini owodwa, ukunciphisa isidingo semishini eyinkimbinkimbi nezinqubo.

Kodwa-ke, indlela yokukhiqiza yesigaba se-liquid nayo inezihibe ezithile. Ukusabela kungadala ukushisa, okufanele kulawulwe ngokucophelela ukugwema izinkinga zokuphepha. Ukusetshenziswa kwezincibilikisi nakho kungadala izingozi zemvelo nempilo, futhi inqubo yokuhlanza ingase idle isikhathi futhi ibize.

Sengiphetha, indlela yokukhiqiza yesigaba samanzi iyindlela esetshenziswa kabanzi yokukhiqiza i-HPMC. Indlela ihilela ukusabela kwe-MC nge-PO ne-PG ngaphansi kwezimo ezithile, kulandelwa ukuhlanzwa nokomiswa. Nakuba le ndlela inezinye izithiyo, izinzuzo zayo ziyenza ibe ukukhetha okuthandwayo ezimbonini nasezithakazelweni zemithi.