Inqubo yokugeleza kwe-hydroxypropylylylm methylcellulose

I-Hydroxypropyl methylcellulose (HPMC)I-cellulose esetshenziswayo esetshenziswayo esetshenziswayo ye-cellulose esetshenziswayo, esetshenziswa kabanzi ekwakheni, ukumboza, amakhemikhali, ukudla kanye nezimonyo. Inqubo yayo yokukhiqiza iyinkimbinkimbi futhi ifaka izinyathelo eziningi, ikakhulukazi kufaka phakathi ukuqedwa, ukusabela, ukugeza, ukomisa nokuchoboza i-cellulose.

1. Ukulungiswa okubonakalayo okuluhlaza

Ukukhiqizwa kwe-Hydroxypropylllylylylykyl methylcellulose kusebenzisa izitshalo ezinjengezinkuni noma ukotini njengezinto ezingavuthiwe. Okokuqala, i-cellulose idinga ukukhishwa esitshalweni. I-cellulose ekhishwe ngokuvamile iyehla, ihlanganiswe, futhi ukungcola - kususwe ukuthola izinto ezihlanzekile ze-cellulose.

2. Ukuchithwa kwe-cellulose

I-cellulose ine-soubity empofu emanzini, ngakho-ke idinga ukuchithwa yi-solvent ngesikhathi sokukhiqiza. Izixazululo ezijwayelekile ziyingxube ye-ammonium chloride namanzi, noma ingxube ye-ammonia ne-ethanol. Okokuqala, i-cellulose emsulwa ixubene ne-solvent futhi iphathwe ekushiseni okuphezulu ukuze iqinisekise ukuthi i-cellulose ingachithwa ngokuphelele.

3. Ukusabela kwe-methylation

I-methylating ejenti (efana ne-methyl chloride noma i-methyl chloride) ingezwe ku-cellulose ecijile ukusabela kwe-methylation. Inhloso enkulu yalokhu kusabela ukwethula amaqembu we-methyl (-Och₃) ukwakha i-methyl cellulose. Le nqubo ngokuvamile idinga ukwenziwa emvelweni ye-alkaline, kanye nokulawulwa kokushisa kwendlela nesikhathi sokushisa kunethonya elibalulekile esakhiweni samangqamuzana nakwenziwa komkhiqizo wokugcina.

4. I-HYDROXYPROPYLY SERRECTION

I-methylated cellulose iqhubeka nokuphendula nge-acrylates (njenge-alllyl chloride) ukwethula amaqembu we-hydroxypropyl (-Och₂ch₃). Lokhu kusabela kuvame ukwenziwa kwikhambi le-alkaline, kanye nokulawulwa kokushisa okusheshayo nesikhathi sokuphendula kunquma okuqukethwe kwe-hydroxypropyl. Izinga le-hydroxypropylation lithinta ngqo i-solubity, i-viscosity nezinye izakhiwo zenyama nezamakhemikhali ze-HPMC.

5. Ukungathathi hlangothi nokugeza

Ngemuva kokuthi ukusabela sekuqediwe, ezinye izinto ze-alkaline noma ama-reagents angabhalisiwe angahlala ohlelweni. Ngakho-ke, kuyadingeka ukususa izinto ezeqile ze-alkaline ngokwelashwa okungathathi hlangothi. Ukungathathi hlangothi kuvame ukwenziwa nge-acid (njenge-acetic acid noma i-hydrochloric acid), futhi usawoti ongathathi hlangothi uzokhiqizwa ngemuva kokuphendula kwe-acid-base. Kamuva, ukungcola kusisombululo kususwa ngokugeza okuningi ukuqinisekisa ubumsulwa bomkhiqizo.

6. Ukuphelelwa ngamandla nokomisa

Isixazululo se-cellulose egeziwe sidinga ukuphelelwa amanzi emzimbeni, futhi ukuhwamuka noma i-ultrafiltration kuvame ukusetshenziselwa ukususa amanzi. Ukumiswa kwe-cellulose okukhanyisiwe kuqukethe ukugxila okuphezulu kwento eyomile, bese kungena kwinqubo yokumisa. Indlela yokumisa ingaba somiswa okufafaza, ukomisa noma ukomisa umoya oshisayo. Ukulawulwa kokushisa ngesikhathi senqubo yokumisa kubaluleke kakhulu. Ukushisa okuphezulu kakhulu kungadala ukuthi umkhiqizo unciphise noma ulahlekelwe ukusebenza kwawo okulindelekile.

7. Ukuchoboza nokubukwa

I-hydroxyproppropyllyrprose methylcellulose esomile kwifomu le-powder futhi lidinga ukuchotshozwa futhi liphuze ukulawula usayizi womkhiqizo wezinhlayiyana. Inqubo yokuqhakambisa ingaqinisekisa ukufana komkhiqizo nokususa ukungcola ngezinhlayiya ezinkulu.

8. Ukupakishwa nokugcinwa

I-hydroxypropyllylylylrose ephumayo ingakhiqizwa ngamafomu ahlukene wokupakisha ngokuya ngezidingo zamakhasimende, njengezikhwama, imigqomo, njll. Bheka ngokukhethekile ukufakwa komswakama ukuvikela umswakama okutholakale. Umkhiqizo ohlanganisiwe kufanele ugcinwe endaweni eyomile nepholile ukugwema izinga lokushisa eliphakeme nomswakama.

9. Ukulawulwa kwekhwalithi

Ukulawulwa kwekhwalithi okuqinile kuyadingeka kuzo zonke izixhumanisi ezisezinhlelweni zokukhiqiza ukuze uqinisekise ukuthi umkhiqizo wokugcina uhlangabezana nezindinganiso. Izinto ezijwayelekile zokuhlola zifaka phakathi: I-Solubity, I-Viscosity, Inani le-PH, okuqukethwe okungcothweni kanye nokuqukethwe komswakama. Izakhiwo zomkhiqizo zithinta ngqo umphumela wazo emikhakheni yohlelo lokusebenza ehlukene, ngakho-ke ukulawulwa kwekhwalithi kuyisixhumanisi esibalulekile ekukhiqizweni kweHydroxypropylylylylyl.

Inqubo yokukhiqiza yehydroxypropyl methylcelluloseKubandakanya ukusabela kwamakhemikhali okuningi kanye nezinyathelo zokwelashwa ngokomzimba, futhi zinezidingo eziphakeme zemibandela yenqubo. Ukushisa okushisa, isikhathi, inani le-PH nezinye izinto kumele kulawulwe ngokuqinile ekukhiqizeni ukuthola imikhiqizo ngokusebenza okuhle. Ngokuthuthuka kwesayensi nobuchwepheshe kanye nokuthuthukiswa kobuchwepheshe bokukhiqiza, inqubo yokukhiqiza ye-HPMC ihlala ithuthuka, futhi insimu yesicelo somkhiqizo nayo iyanda.