I-HPMC Hypromellose

IHydroxypropyl Methylcellulose(HPMC), iyinhlanganisela yamakhemikhali esebenza ngezindlela eziningi enefomula ethi [C6H7O2(OH)3-mn(OCH3)m(OCH2CH(OH)CH3)n]x, lapho u-m emelela izinga lokushintshwa kwe-methoxy futhi n emele izinga le-hydroxypropoxy esikhundleni. Itholakala ku-cellulose, i-polymer yemvelo etholakala ezindongeni zamaseli ezitshalo. I-HPMC ayinaphunga, ayinambitheki, futhi ayinabuthi. Inezici ezihlukahlukene ze-physicochemical ezifana nokuncibilika emanzini, izakhiwo ze-gelation ezishisayo, kanye nekhono lokwenza amafilimu, okwenza asetshenziswe kabanzi ezimbonini eziningi.

Embonini yezemithi, i-HPMC isetshenziswa kakhulu njenge-excipient—into ekhiqizwe eduze kwesithako esisebenzayo somuthi, ngenhloso yokusimamisa isikhathi eside, ukunqwabelanisa ukwakheka okuqinile okuqukethe izithako ezisebenzayo ezinamandla ngamanani amancane (ngakho ngokuvamile kubhekiselwa kuwo njengesigcwalisi, i-diluent, noma umthwali), noma ukuthuthukisa ukumuncwa noma ukuncibilika. Amaphilisi e-HPMC ahlukile kumakhepsuli e-gelatin kwabadla imifino futhi asetshenziswa ekwenziweni kokukhishwa okulawulwayo, okuvumela ukukhishwa kancane komuthi ngokuhamba kwesikhathi. Izixazululo ze-HPMC zingasebenza njengeziviscolyzer zokwandisa i-viscosity yezixazululo ze-ophthalmic, ukuthuthukisa ukubambelela kwe-bioadherence, nokwandisa isikhathi sokuhlala kwezidakamizwa endaweni ye-ocular.

Embonini yokudla, i-HPMC yaziwa njengesengezo sokudla esiphephile (E464) futhi isebenzisa imisebenzi eminingi efana ne-emulsifier, i-ejenti yokuqina, kanye nesiqinisi. Isetshenziswa ekukhiqizeni ukudla okunhlobonhlobo ukuthuthukisa ukuthungwa, ukugcina umswakama, nokwenza amafilimu adliwayo. I-thermal gelation property ye-HPMC ibaluleke kakhulu ekusetshenzisweni okudinga i-gelling emazingeni okushisa athile, njengalapho kutholakala khona imifino nemifino lapho ingashintsha khona i-gelatin. I-HPMC futhi inikela empilweni yeshalofu kanye nekhwalithi yezimpahla ezibhakiwe, amasoso, nama-dessert ngokulawula ukucwebezela kanye nomswakama.

Imboni yezokwakha izuza ku-HPMC ekwenzeni izinto zokwakha. Izicelo zakhona zihlanganisa ukusebenza njenge-binder kanye ne-ejenti yokugcina amanzi odakeni, kumapulasi, nama-coatings, ukuthuthukisa ukusebenza kahle, ukunciphisa ukusetshenziswa kwamanzi, nokwelula isikhathi esivulekile - isikhathi lapho okubalulekile kuhlala kusebenziseka. I-HPMC ithuthukisa izici zokwakheka okusekelwe kusimende, inikeze ukunamathela okungcono, ukusabalala, kanye nokumelana nokuncipha.

Embonini yezimonyo nokunakekelwa komuntu siqu, i-HPMC isebenza njenge-ejenti eyenza ifilimu, i-emulsifier, nesilungisi se-rheology emikhiqizweni efana nezigcobo, okhilimu, namajeli ezinwele. Ukuhambisana kwayo nezinhlobo ezahlukene zesikhumba kanye nekhono lokuzinzisa ama-emulsions kuthuthukisa ukusebenza komkhiqizo nokuphila isikhathi eside. Izakhiwo ze-HPMC ze-hydration ziyenza ibe isithako esifiselekayo imikhiqizo yokunakekelwa kwesikhumba, esiza ukugcina umswakama futhi inikeze ukuzwa okubushelelezi. Kafushane, ukusebenzisana kwe-HPMC kuhlanganisa imithi, ukudla, ukwakhiwa, nezimonyo, kugqamisa ukubaluleka kwayo njengesithako esisebenza ngezindlela eziningi ezinhlelweni ezihlukene.