Amathontsi eeye luhlobo olubalulekileyo lonikezelo lwamayeza kwiimeko ezahlukeneyo zamehlo, ukusuka kwi-syndrome yamehlo eyomileyo ukuya kwi-glaucoma. Ukusebenza kunye nokhuseleko lwale miqulu kuxhomekeke kwizinto ezininzi, kubandakanywa izithako zabo. Esinye sezithako esibaluleke ngolo hlobo esifunyenwe kwimixube emininzi yethontsi yamehlo yiHydroxypropyl Methylcellulose (HPMC).
1. Ukuqonda i-HPMC:
I-HPMC yi-semisynthetic, ipholima enyibilikayo emanzini ephuma kwiselulosi. Ngokwekhemikhali, yi-ether ye-cellulose apho amaqela e-hydroxyl e-cellulose backbone athatyathwa endaweni yamaqela e-methyl kunye ne-hydroxypropyl. Olu hlengahlengiso luphucula ukunyibilika kwayo, ukuhambelana kwebhayoloji, kunye nokuzinza, kuyenza ifaneleke kwizicelo ezahlukeneyo zamayeza.
2.Indima ye-HPMC kumathontsi wamehlo:
Viscosity kunye nokuthambisa:
Omnye wemisebenzi ephambili ye-HPMC kwi-eye drops kukulungelelanisa i-viscosity yokwakheka. Ukongezwa kwe-HPMC kwandisa i-viscosity yesisombululo, inceda ekwandiseni ixesha loqhagamshelwano lweyeza kunye nomphezulu we-ocular. Olu qhagamshelwano luthatha ixesha elide luqinisekisa ukufunxwa nokusasazwa kwechiza ngcono. Ngaphezu koko, i-viscous nature ye-HPMC ibonelela ngokuthambisa, ukukhulula ukungonwabi okuhambelana neemeko zamehlo omileyo kunye nokuphucula intuthuzelo yesigulana xa kufakwe.
Ukunamathela:
I-HPMC ineempawu ze-mucoadhesive, eyenza ukuba ibambelele kumphezulu we-ocular xa ilawulwa. Oku kubambelela kwandisa ixesha lokuhlala iyeza, ukukhuthaza ukukhululwa okuqhubekayo kunye nokuphucula ukusebenza konyango. Ukongezelela, i-mucoadhesion iququzelela ukubunjwa kwesithintelo sokukhusela phezu kwe-cornea, ukukhusela ukulahleka komswakama kunye nokukhusela iliso kwizinto ezicasulayo zangaphandle.
uKhuseleko lwe-Ocular Surface:
Ubukho be-HPMC kumathontsi esweni budala ifilimu ekhuselayo kumphezulu we-ocular, ukuyikhusela kwizinto ezisingqongileyo ezifana nothuli, izinto ezingcolisa umzimba, kunye nezinto ezimele ukubaleka. Lo mqobo wokukhusela awugcini nje ukwandisa induduzo yesigulane kodwa ukhuthaza ukuphulukiswa kwe-ocular kunye nokuvuselelwa, ngakumbi kwiimeko ze-corneal abrasions okanye umonakalo we-epithelial.
Unikezelo lweziyobisi olomeleziweyo:
I-HPMC iququzelela i-solubilization kunye nokusasazwa kwamachiza anganyibiliki kakuhle kwizisombululo ezinamanzi, ngaloo ndlela iphucula i-bioavailability kunye nokusebenza ngempumelelo konyango. Ngokwenza izakhiwo ezifana ne-micelle, i-HPMC ifakela iimolekyuli zamachiza, zithintele ukudityaniswa kwazo kunye nokuphucula ukusasazeka kwazo ngaphakathi kwe-eye drop formulation. Oku kunyibilika okongeziweyo kuqinisekisa ukuhanjiswa kwechiza okufanayo xa kufakwe, okukhokelela kwiziphumo zonyango ezingaguqukiyo.
Uzinziso lokuGcina:
Imixube yethontsi yamehlo isoloko inezithinteli zokuthintela ukosuleleka ziintsholongwane. I-HPMC isebenza njenge-arhente yozinziso kwezi zithinteli, igcina ukusebenza kwayo kubomi beshelufa bemveliso. Ukongeza, i-HPMC inciphisa umngcipheko wokucaphuka kwe-ocular okwenziwa ngolondolozo okanye ubuthi ngokwenza umqobo okhuselayo othintela unxibelelwano oluthe ngqo phakathi kwezithinteli kunye nomphezulu we-ocular.
3.Ukubaluleka kwe-HPMC kwi-Ocular Therapeutics:
Ukuthotyelwa kwesigulana kunye nokunyamezeleka:
Ukufakwa kwe-HPMC kwi-eye drop formulations kuphucula ukuthotyelwa kwesigulane kunye nokunyamezela. Iimpawu zayo zokuphucula i-viscosity zandisa ixesha lokudibanisa iyeza ngeso, ukunciphisa ukuphindaphinda kolawulo. Ngaphezu koko, iimpawu zokuthambisa kunye ne-mucoadhesive ye-HPMC yongeza intuthuzelo yesigulana, inciphisa ukucaphuka kunye nokungonwabi okuyanyaniswa nokufakwa kwamehlo.
Ukuguquguquka nokuhambelana:
I-HPMC iyahambelana noluhlu olubanzi lwezithako ezisebenzayo zamachiza, iyenza ilungele ukuqulunqa iintlobo ezahlukeneyo zamathontsi eliso, kubandakanya izisombululo ezinamanzi, ukunqunyanyiswa, kunye namafutha. Ukuguquguquka kwayo kuvumela ukwenziwa ngokwezifiso kokwakheka ukuze kuhlangatyezwane neemfuno zonyango ezithile zeemeko zamehlo ezahlukeneyo, ezifana nesifo samehlo esomileyo, iglaucoma, kunye ne-conjunctivitis.
Ukhuseleko kunye neBiocompatibility:
I-HPMC yamkelwa njengekhuselekile kwaye iyahambelana nebhayoloji zii-arhente ezilawulayo ezifana ne-FDA kunye ne-EMA, iqinisekisa ukufaneleka kwayo kusetyenziso lwamehlo. Ubume bayo obungenabuthi kunye nokungathukutheli kunciphisa umngcipheko wokuphendula okungalunganga okanye ubuthi be-ocular, buyenze ilungele unyango lwexesha elide kunye nokusetyenziswa kwabantwana. Ukongeza, i-HPMC iyakwazi ukubola, ibeka impembelelo encinci yokusingqongileyo xa ichithwa.
IHydroxypropyl Methylcellulose (HPMC) idlala indima ebalulekileyo ekuqulunqweni kwamathontsi esweni, inegalelo kwi-viscosity yawo, i-lubrication, i-mucoadhesion, ukukhuselwa komphezulu we-ocular, ukuhanjiswa kweziyobisi okuphuculweyo, kunye nokugcinwa kozinzo. Ukufakwa kwayo ekuqulunqweni kwe-eye drop drops kwandisa ukuthotyelwa kwesigulane, ukunyamezela, kunye nokusebenza kakuhle kwonyango, okwenza kube sisiseko sonyango lwe-ocular therapeutics. Ngaphaya koko, ukhuseleko lwe-HPMC, ukuhambelana kwebhayoloji, kunye nokuguquguquka kwezinto ezininzi kugxininisa ukubaluleka kwayo njengesithako esiphambili kulwakhiwo lwamehlo. Njengoko uphando kunye nobuchwepheshe buqhubeka buqhubela phambili, ezinye izinto ezintsha kwi-HPMC-based eye drops kulindeleke, zithembisa iziphumo eziphuculweyo zonyango kunye neziphumo zesigulane kwinkalo ye-ophthalmology.
Ixesha lokuposa: Mar-09-2024