Ibakala lamachizaihydroxypropyl methylcellulose (HPMC)yinto esetyenziswa ngokuqhelekileyo kwimveliso yamayeza, esetyenziswa ngokubanzi kwishishini lamachiza ngenxa ye-biocompatibility yayo egqwesileyo kunye nokuzinza.
1. Abancedisi kumalungiselelo amayeza
I-HPMC idla ngokusetyenziswa njenge-excipient kumalungiselelo amayeza, ikakhulu ukulungiselela iipilisi, ii-capsules, i-granules, njl.njl. Inokuphucula ulwelo kunye nokunyanzeliswa kweziyobisi, kunye nokuphucula ukunyibilika kunye nokufumaneka kwamachiza. Ekubeni i-HPMC ine-adhesion ebalaseleyo, ukusetyenziswa kwayo kwiipilisi kunokunyusa ngokufanelekileyo amandla kunye nokuzinza kweepilisi.
2. I-arhente yokukhululwa elawulwayo
I-HPMC isetyenziswa ngokubanzi kumalungiselelo okukhululwa alawulwayo. Umlinganiselo wokukhutshwa kweziyobisi unokutshintshwa ngokuguqula ubunzima be-molecular and viscosity ye-HPMC. Iipropathi ezinyibilikayo zamanzi ze-HPMC zivumela ukuba zenze iijeli emanzini, ngaloo ndlela zilawula izinga lokukhululwa kwamachiza kunye nokuphumeza ukukhutshwa kweziyobisi okuqhubekayo. Le propati ibaluleke kakhulu kunyango lweziyobisi zezifo ezingapheliyo ezifana nesifo sikashukela kunye noxinzelelo lwegazi.
3. Izityebi zezisombululo kunye nokunqunyanyiswa
I-HPMC, njenge-thickener, inokunyusa ngokufanelekileyo i-viscosity yezisombululo kunye nokumiswa kunye nokuphucula ukuzinza kunye nokusebenza kwamachiza. Kumalungiselelo olwelo, ukusetyenziswa kwe-HPMC kunokuphucula ukunqunyanyiswa kweziyobisi, kunqande imvula, kwaye kuqinisekise ukufana kweziyobisi.
4. Amalungiselelo angaphandle
I-HPMC ikwasetyenziswa ngokubanzi kumalungiselelo angaphandle (afana neekhrimu, iigels, iipatches, njl.). Ngenxa yokubambelela kakuhle kunye neempawu zokuthambisa, i-HPMC inokwandisa ukusasazeka kunye nokunyanzeliswa kwesikhumba kumalungiselelo angaphandle kunye nokuphucula ukusebenza kakuhle kwamachiza. Ukongeza, i-HPMC inokubonelela ngokubambelela kakuhle xa ulungiselela iipetshi zebhayoloji ukuqinisekisa ukubambelela okuzinzileyo kwamabala eluswini.
5. Amalungiselelo e-Ophthalmic
Kumalungiselelo e-ophthalmic, i-HPMC isetyenziswa njengenxalenye yeenyembezi ezenziweyo kunye namaconsi esweni. I-viscosity yayo ephezulu kunye neempawu zokuthambisa zinokukhulula ngokufanelekileyo amehlo omileyo, zinike i-lubrication ehlala ixesha elide, kwaye ziphucule intuthuzelo yesigulane.
6. Abathwali beziyobisi beNano
Kwiminyaka yakutshanje, i-HPMC iye yaphononongwa njenge-nano carrier carrier. Ngokudibanisa ne-nanoparticles, i-HPMC inokuphucula i-bioavailability yamachiza, ukunciphisa ubuthi, kunye nokufezekisa ukuhanjiswa kweziyobisi ezijoliswe kuyo. Olu phando lubonelela ngeembono ezintsha kunyango lwezifo ezinganyangekiyo ezifana nomhlaza.
7. Izinto zeBiomedical
I-biocompatibility yeHPMCikwayenza ibe luncedo kwicandelo lezinto eziphilayo. Ingasetyenziselwa ukulungiselela i-biofilms, i-scaffolds, njl., Ukukhuthaza ukukhula kweeseli kunye nokuvuselelwa, kwaye isetyenziswe kubunjineli bezicubu kunye neyeza lokuvuselela.
8. Ezinye izicelo
Ukongeza kolu setyenziso lungentla, i-HPMC ikwasetyenziswa ekutyeni, kwizinto zokuthambisa kunye nezinye iindawo njengento etyebisayo kunye nokuzinzisa. Ngokomzekelo, ekutyeni, i-HPMC ingasetyenziselwa ukuphucula ukuthungwa kunye nencasa yokutya; kwizithambiso, ingasetyenziselwa njenge-thickener kunye ne-emulsifier ukuphucula ukuzinza kunye nokuvakalelwa kwemveliso.
Ibakala lobuChiza i-HPMC iye yaba sisixhobo esiyimfuneko kwinkalo yoxubo-mayeza kunye ne-biomedical ngenxa yokuguquguquka kwayo kunye nokuhambelana kwebhayoloji okugqwesileyo. Ngophuhliso lwesayensi kunye nobuchwepheshe, umda wokusetyenziswa kunye nobuchwepheshe be-HPMC iya kuqhubeka isanda, inikezela ngenkxaso yokuphuhliswa kwamalungiselelo amatsha amachiza kunye neendlela zonyango. Kwixesha elizayo, uphando nge-HPMC luya kuba nzulu ngakumbi, lubeka isiseko sokusetyenziswa kwayo kuluhlu olubanzi lweenkalo.
Ixesha lokuposa: Nov-07-2024