1. Ubume beMichiza ye-HPMC:
I-HPMC yi-semi-synthetic, inert, i-viscoelastic polymer ephuma kwi-cellulose. Idityaniswe ngeeyunithi eziphinda-phindayo zeemolekyuli zeglucose ezidityaniswe kunye, kunye namanqanaba ahlukeneyo okutshintsha. Ukutshintshwa kubandakanya i-hydroxypropyl (-CH2CHOHCH3) kunye namaqela e-methoxy (-OCH3) aqhotyoshelwe kwiiyunithi ze-anhydroglucose ze-cellulose. Olu tshintsho lunika iipropati ezizodwa kwi-HPMC, kubandakanywa nokunyibilika kwayo emanzini.
2. Ukudityaniswa kweHydrojeni:
Esinye sezizathu eziphambili zokunyibilika kwe-HPMC emanzini kukukwazi ukwenza iibhondi ze-hydrogen. Ukudibanisa i-Hydrogen kwenzeka phakathi kwamaqela e-hydroxyl (OH) e-HPMC kunye ne-molecule zamanzi. Amaqela e-hydroxyl kwiimolekyuli ze-HPMC zinokusebenzisana nama-athomu zamanzi ngokusebenzisa i-hydrogen bonding, iququzelele inkqubo yokuchithwa. La mandla e-intermolecular abalulekile ekwaphuleni amandla anomtsalane phakathi kweemolekyuli ze-HPMC kunye nokwenza ukuba zisasazeke emanzini.
3. Isidanga soTshintsho:
Iqondo lokutshintsha (DS) libhekiselele kumndilili wenani le-hydroxypropyl kunye namaqela e-methoxy ngeyunithi ye-anhydroglucose kwi-molecule ye-HPMC. Amaxabiso aphezulu e-DS aphucula ngokubanzi ukunyibilika kwamanzi kwe-HPMC. Oku kungenxa yokuba inani elongezelelweyo le-hydrophilic substituents liphucula intsebenziswano yepolymer kunye neemolekyuli zamanzi, ukukhuthaza ukuchithwa.
4. Ubunzima beMolekyuli:
Ubunzima bemolekyuli ye-HPMC ikwaphembelela ukunyibilika kwayo. Ngokubanzi, amabanga asezantsi obunzima bemolekyuli HPMC abonisa ukunyibilika okungcono emanzini. Oku kungenxa yokuba amakhonkco amancinci epolymer aneendawo ezifikeleleka ngakumbi zokunxibelelana neemolekyuli zamanzi, ezikhokelela ekunyibilikeni ngokukhawuleza.
5. Ukudumba:
I-HPMC inamandla okudumba kakhulu xa ibhengezwe emanzini. Oku kudumba kwenzeka ngenxa yobume bepolymer's hydrophilic kunye nokukwazi kwayo ukufunxa iimolekyuli zamanzi. Njengoko amanzi engena kwi-matrix ye-polymer, iphazamisa amandla e-intermolecular phakathi kwamatyathanga e-HPMC, okukhokelela ekuhlukaneni kwawo kunye nokusabalalisa kwi-solvent.
6. Inkqubo yokusasaza:
Ukunyibilika kwe-HPMC emanzini kukwaphenjelelwa yindlela yokusasazwa kwayo. Xa i-HPMC yongezwa emanzini, ingena kwinkqubo yokumanzisa, apho iimolekyuli zamanzi zijikeleze amasuntswana epolymer. Emva koko, iinqununu ze-polymer zichithakala kuyo yonke i-solvent, incediswa yi-agitation okanye i-mechanical mixing. Inkqubo yokusabalalisa iququzelelwa yi-hydrogen bonding phakathi kwe-HPMC kunye neemolekyuli zamanzi.
7. Amandla e-Ionic kunye ne-pH:
Amandla e-ionic kunye ne-pH yesisombululo inokuchaphazela ukunyibilika kwe-HPMC. I-HPMC inyibilika ngakumbi emanzini ngamandla e-ionic aphantsi kunye ne-pH ekufutshane-phakathi. Izisombululo zamandla e-ionic aphezulu okanye iimeko ezigqithisileyo ze-pH zinokuphazamisana ne-hydrogen bonding phakathi kwe-HPMC kunye ne-molecule zamanzi, ngaloo ndlela ukunciphisa ukunyibilika kwayo.
8. Ubushushu:
Ubushushu bunokuchaphazela ukunyibilika kwe-HPMC emanzini. Ngokubanzi, amaqondo okushisa aphezulu aphakamisa izinga lokuchithwa kwe-HPMC ngenxa yokwanda kwamandla e-kinetic, okukhuthaza ukunyakaza kwee-molecular kunye nokusebenzisana phakathi kwepolymer kunye ne-molecule yamanzi.
9. Ukugxila:
Ukuxinwa kwe-HPMC kwisisombululo kunokuchaphazela ukunyibilika kwayo. Kwiindawo ezisezantsi, i-HPMC inyibilika ngokulula emanzini. Nangona kunjalo, njengoko uxinaniso lukhula, amatyathanga epolymer anokuqalisa ukudityaniswa okanye ukubambisa, okukhokelela ekunciphiseni ukunyibilika.
10. Indima kuCwangciso lwezaMachiza:
I-HPMC isetyenziswa ngokubanzi kuqulunqo lwamachiza njengepolymer ye-hydrophilic ukuphucula ukunyibilika kwechiza, ukufumaneka kwe-bioavailability, kunye nokukhululwa okulawulwayo. Ukunyibilika kwayo okugqwesileyo kwamanzi kuvumela ukulungiswa kweefom zedosi ezizinzileyo nezihlakazeka ngokulula ezifana neetafile, iicapsules, kunye nokuxhonywa.
ukunyibilika kwe-HPMC emanzini kubalelwa kubume bayo beekhemikhali ezizodwa, ezibandakanya i-hydrophilic hydroxypropyl kunye namaqela e-methoxy, iququzelela ukuhlangana kwe-hydrogen kunye neemolekyuli zamanzi. Ezinye izinto ezinje ngeqondo lokutshintsha, ubunzima bemolekyuli, isimilo sokudumba, indlela yokusasazeka, amandla e-ionic, i-pH, ubushushu, kunye noxinzelelo nazo zinefuthe kwiipropati zayo zokunyibilika. Ukuqonda ezi zinto kubalulekile ekusebenziseni i-HPMC ngempumelelo kwizicelo ezahlukeneyo, kubandakanya amayeza, ukutya, izinto zokuthambisa, kunye namanye amashishini.
Ixesha lokuposa: Mar-21-2024