Iimpawu ze-viscosity yempawu ze-hydroxypropyl methylcelsele (i-HPMC) I-ACTEAR

Hydroxypropyl methylcelculose (hpmc)sisiporho esinyibiliki esisezantsi samanzi esinezicelo ezahlukeneyo, ngakumbi kwiindawo zamayeza, ukutya kunye neemveliso zecosmetic. Ukukwazi kwayo ukwenza izisombululo ezinobunzima, ezinjengejeli xa zidityaniswa namanzi ziyenza isithako esiguquguqukayo. I-viscosity ye-kimbacell®hpms Solutions idlala indima ebalulekileyo ekuqinisekiseni ukusebenza kwabo ngeendlela ezahlukeneyo. Ukuqonda iimpawu zokundwendwela kwezisombululo ze-HPMC ze-HPMC eziphezulu kubalulekile ukuze zisetyenziswe kuwo kumashishini ahlukeneyo.

1. Intshayelelo kwi-HydroxyPOpyl Methylcelceluplose (HPMC)

I-HydroxyPOpyl Methylcelcelgalose yi-semi-syntgetic ye-seluplose. Iveliswa kukufakwa endaweni yeselpulose kunye namaqela e-hydroxypropy ye-hydroxyl kunye namaqela e-methyl. Umyinge wale nto unokufakwa endaweni yahluka, ukhokela kumabakala ahlukeneyo ee-HPMC ngeempawu ezahlukeneyo, kubandakanya i-viscosity. Ulwakhiwo oluqhelekileyo lwe-HPMC liqukethe i-selllose yeselfowuni kunye ne-hydroxylpropyl kunye namaqela e-methyl aqhotyoshelwe kwiiyunithi zeGlucose.

I-HPMC isetyenziswa kwimizi-mveliso eyahlukeneyo ngenxa ye-biomatise, ukukwazi ukwenza i-geses, kunye nokukhululeka kwe-solity emanzini. Kwizisombululo ze-ACPMC, i-HPMC iziphatha njenge-polymer engeyiyo i-ionic, i-poly-bicmer eselwelwe ngamanzi ebambelela ngokuthe gabalala i-suheologries ye-suheolotical yesisombululo, ngakumbi i-viscofity.

2. Iimpawu ze-viscosity yezisombululo ze-HPMC

UVenkile weZisombululo ze-HPMC ichukunyiswa zizinto ezininzi, kubandakanya ne-HPMC, ubunzima bemoya yesimobi, ubushushu, kunye nobukho beetyuwa okanye ezinye izisombululo. Apha ngezantsi kukho izinto eziphambili ezilawula iimpawu zokubonisa i-HPMC kwizisombululo ze-ACTEAGE:

Uxinzelelo lwe-HPMC: I-viscosity inyuka njengoko uxinzelelo lwe-HPMC. Kwiimeko eziphezulu, iimolekyuli ze-HPMC zinxibelelana kakhulu kunye, zikhokelela ekuchaseni okuphakathi kokuhamba.

Ubunzima bemolekyuli ye-HPMCI-viscosity yezisombululo ze-HPMC ihambelana ngokuqinileyo nobunzima bemoyam yePolymer. Amabakala aphezulu eemolekyuli ze-HPMC adla ngokuvelisa izisombululo ze-viscous. Kungenxa yokuba iimolekyuli ezinkulu ezinkulu zidala ukunganyangeki okubonakalayo ekuhambeni ngenxa yokuntywila kwabo kunye nokuxabana.

Ubushushu: I-Viscosity ihlala inciphisa njengoko ubushushu bunyuka. Kungenxa yokuba ubushushu obuphezulu bubangela ukuncitshiswa kwemikhosi ye-premolecular phakathi kweemolekyuli ze-HPMC, ngaloo ndlela kunciphisa amandla abo okuxhathisa ukuhamba.

Ixabiso le-ShearI-viscosity yezisombululo ze-HPMC ngumgangatho we-Shear-Ukuxhomekeka kulwelo olungelulo lweNewtonian, oluqhelekileyo lwezisombululo zepolymer. Ngamaxabiso asezantsi asezantsi, izisombululo ze-HPMC ezibonisa i-viscosity ephezulu, ngelixa amaxabiso aphezulu asechibini, i-viscosity ihla ngenxa yokuziphatha kwe-shear.

Iziphumo zamandla e-Ionic: Ubukho bama-electrolytes (ezinjengeetyiwa) kwisisombululo unokutshintsha i-viscofity. Ezinye iityuwa zinokukrokrela imikhosi ephindaphindiweyo phakathi kwamakhonkco ePolymer, ebangela ukuba bacaphukise kwaye babangele ukwehla kwi-viscofity.

3. I-Viscofity vs. Uxinzelelo: Uvavanyo lovavanyo

Imo yokuzihlaziya eboniswe kwiimvavanyo kukuba i-viscodosity yezisombululo ze-HPMC inyusa ngokungqongqo ngokukhulisa i-polymer gxini. Ulwalamano phakathi kophawu lwe-viscofity kunye noxinzelelo lungachazwa yile quation ilandelayo, edla ngokusetyenziswa kwizisombululo zePolymer:

η = i-acn ​​\ eta = i-AC ^ nη = i-acn

Phi:

η \ ye-etaη yi-viscofity

I-CCC kukuxinezeleka kwe-HPMC

I-AAA kunye ne-NNN i-svaricals i-vissies exhomekeke kuhlobo oluthile lwe-HPMC kunye neemeko zesisombululo.

Ngobuso obusezantsi, ubudlelwane buyeyona nto ilayini, kodwa njengoko uxinzelelo luyanyuka, ukuvela kwe-viscofity kunyuka ngokugqibeleleyo, ukubonakalisa ukusebenzisana okwandisiweyo phakathi kwemixokelelwane yePolymer.

4. I-Viscofity vs i-vs

Ubunzima bemolekyuli ye-kimbacell®hpmc idlala indima ebalulekileyo kwiimpawu zayo zokubonisa. I-rolecular ye-sulecular ye-rolecular ye-HPMC idla ngokwenza izisombululo ze-viscous kwizisombululo ze-viscous kwiindawo ezisezantsi xa zithelekiswa namabanga aphantsi emilinganiselo yemolekyuli. I-viscosity yezisombululo ezenziwe ukusuka kwi-molecular-molecular-ubunzima i-HPMC ingaphezulu kwee-odolo ezininzi zobukhulu obungaphezulu kuneso sezisombululo ezenziwe kwi-molecur-phumi.

Umzekelo, isisombululo se-HPMC esinomsindo we-100,000 da uza kubonisa i-viscofity ephezulu kunenye enobunzima obuyi-50 da kwi-da ye-folecular i-50 da kwixinzelelo olufanayo.

5. Ubushushu obuQhilelo kwi-viscofity

Iqondo lokushisa linempembelelo ebonakalayo kuhlobo lwe-HPMC. Ukonyuka kwamaqondo obushushu kukhokelela ekunciphiseni kwi-viscofity yesisombululo. Oku ngokuyintloko ngenxa yokuhamba kwe-thermal yamakhonkco ePolymer, ebangela ukuba bahambe ngokukhululekileyo, banciphise ukuxhathisa kwabo ukuhamba. Iziphumo zobushushu kwi-viscofity zihlala zihambelana nokusebenzisa i-Ackenius-Equation:

η (t) = η0eart \ eta (t) = \ eta_0 e {\ frac {}} η (T) = η0 ERTEA

Phi:

η (t) \ eta (t) η (t) yi-viscofity kwiqondo lobushushu

η0 \ Eta_0η0 yimeko yangaphambi kwexesha (i-viscofity kwiqondo lokushisa)

I-Eae_aea ngamandla okuvula

I-rrr yigesi rhoqo

I-TTT ibubushushu obuqinisekileyo

6. Ukuziphatha kakuhle

I-RUOOOLOGY ye-HPMC Accoughts Solution ihlala ichazwa njengentsha, intsingiselo yokufakwa kwesisombululo ayihlali rhoqo kodwa iyahluka ngenqanaba le-Shear. Ngamaxabiso asezantsi asezantsi, izisombululo ze-HPMC zibonisa i-viscofity ephezulu ngenxa yokuntywila kwemixokelelwane yePolymer. Nangona kunjalo, njengoko inqanaba le-lopha likhulisa, i-viscosity inciphe-i-phenomenon eyaziwa ngokuba inyibiliki.

Le ndlela yokuziphatha enciphayo iqhelekile kwizisombululo ezininzi zePolymer, kubandakanya i-HPMC. Inqanaba le-Shear Ukuxhomekeka kwe-vickosity elinokuchazwa kusetyenziswa iModeli yomthetho yamandla:

(γ˙) = Kč ˙ I-ETA (\ Dot {\ gamma})

Phi:

γ˙ Dot Dot {\ gamma} γ˙ Ixabiso leShear

IKKK yi-Index yokuThengisa

I-NNN yi-Index yokuziphatha yokuhamba (kunye ne-N <1n <1n <1 ye-shear yokuthoba)

7. I-Viscosity yezisombululo ze-HPMC: itafile yesishwankathelo

Apha ngezantsi kukho itafile eshwankathela iimpawu ze-viscofisity ze-HPMC zeZisombululo eziManyeneyo phantsi kweemeko ezahlukeneyo:

Iimpawu ze-viscosity zeI-HPMCIzisombululo ezizenzisini ziphenjelelwa zizinto ezininzi, kubandakanya uxinzelelo, ubunzima bemolekyuli, ubushushu kunye nenqanaba le-Shear. I-HPMC yindawo eguquguqukayo, kwaye iipropathi zayo zeRhemological zinokulungelelaniswa kwizicelo ezithile ngokuhlengahlengisa ezi parameter. Ukuqonda ezi zinto zivumela ukusetyenziswa ngokupheleleyo kwe-kimbacell®hpmc kwimizi-mveliso eyahlukeneyo, ukusuka kwiindawo zamayeza ukuya kukutya kunye ne-cosmetics. Ngokusebenzisa iimeko apho i-HPMC ichithwe, abavelisi banokufezekisa iipropathi zokuhamba okufunwayo kunye neepropathi zokuhamba kwiimfuno zabo ezithile.