I-Synthesis kunye neempawu zemveliso ze-hydroxypropyl methylcelcelceluplose

Hydroxypropyl methylcelculose (hpmc)Ngaba i-ionic ye-ionsulose i-ether eyenziwe kwiseli yendalo ngokuguqula iikhemikhali. Isetyenziswe ngokubanzi kwicandelo lolwakhiwo, amayeza, ukutya kunye ne-cosmetics. Inkqubo yayo yeSynthesi kunye neempawu zemveliso zinika intsebenzo eyahlukileyo kwaye inokuhlangabezana neentlobo ngeentlobo zeshishini.

1. Synthesis ye-hydroxypropyl methylcelcelceluplose

Ukulungiswa kwe-kimbacell®HPMC isebenzisa isellulose yendalo njengezixhobo ezibukhali kwaye ziyiguqula imichiza ngonyango lwe-alkali kunye nokuphendula kwe-elektroniki. Inkqubo ethile ye-Synthesi ibandakanya la manyathelo alandelayo:

I-Alkalition ye-seluplose

I-Selewsulose Izixhobo ezikrwada (ezinje nge-cotton Pulp okanye i-pulp ye-pulp) ixutywe nesisombululo sesodium hydroxide kwaye ifakwe i-alkalid kwi-Alkali SellUlose. Inkqubo ye-alkali ikhulisa i-selsulose thein kwaye inyuse indawo yayo yokusebenza kunye nearhente yokuthetha.

Ukuphendula kwe-ether

I-Alkali Seluplose iphinda ihlawulwe nge-formaldehyde kunye ne-propylene glycone proplene oxide oxide ukuba ivelise i-hydroxly volcelgulose. Ngexesha lokuphendula, i-methyting kunye ne-Hydroxyproploplopy yenzeka ngaxeshanye, endaweni yenxalenye yamaqela e-hydroxyl kwi-selsulose thein, ngaloo ndlela yenza i-HPMC nge-HPMC enesidanga esithile (i-DS).

Ukungathathi cala kunye nokuhlamba

Emva kokuphendula kugqityiwe, isisombululo se-acidic songezwa ukuze sihlekise umxube wokuphendula, kwaye emva koko sihlanjwe ngamanzi ukuze sisuse izinto ezingafunekiyo kunye neemveliso zokufumana i-HPMC ecocekileyo.

Ukomisa kwaye kutyumza

I-HPMC ye-I-I-HPMC yomiswe kumxholo wokufuma ophantsi kwaye ityumlwe umgubo ukuze ufumane imveliso yokugqibela. Ubungakanani bemveliso yemveliso bunokuhlengahlengiswa ngokweemfuno zesicelo.

2. Iimpawu zemveliso ze-hydroxypropyl methylcelcelcelose

I-HPMC ineepropathi ezizodwa zomzimba kunye neekhemikhali, ezibangela ukuba zihle kwizicelo ezahlukeneyo:

Ukungaziphathi kakuhle kwamanzi

I-HPMC inokuchithwa ngokukhawuleza kumanzi abandayo ukwenza isisombululo esibonakalayo se-colofal, kwaye ukuluka kwayo akuchaphazelekanga bubukhali bamanzi. I-HPMC i-insuble emanzini ashushu, kodwa inokubuyisa ukungcungcutheka emva kokuba amanzi epholile. Le ndawo iyenza ifanelekile imigangatho efuna ukusebenza kwe-thermal.

Iipropathi zeekhemikhali ezizinzileyo

I-HPMC yinto engeyiyo i-ionic enonyamezelo kwi-acid, ialkalis kunye neetyuwa, kwaye inokuhlala uzinzo phantsi kweemeko ezahlukeneyo ze-ps.

Iimpawu ezihle kunye ne-adherion

Isisombululo se-HPMC sineziphumo ezibi kakhulu, kwaye ukubonwa kwalo kunyuka ngokunyuka koxinzelelo kunye nobunzima bemolekyuli. Amalungu ayo kunye neepropathi zokwenza ifilimu zenza ukuba ziwenze kakuhle kwiingubo kunye nemibhede.

Iipropathi ezigqwesileyo ze-thermal

Isisombululo se-HPMC sijonga ubujijekileyo obuguqukayo xa sithobele kwaye sibuyela kwiLizwe loLwimi emva kokupholisa. Le mpahla ye-Thermal ye-Thermal isetyenziswa ngokubanzi kwizinto zokwakha (ezinje ngodaka lwesamente) ukuphucula ukusebenza kokuqala.

Ayisiyo inetyhefu kwaye i-biompatat

Kuba i-HPMC isuselwa kwiseli yemvelo kwaye inee-biomitine elungileyo kunye nokhuseleko, isetyenziswa ngokubanzi kwizinto zokutya kunye nezixhobo zamayeza, ezinje ngezixhobo zeMatrix ezilawulwa ngamacwecwe-therite.

Ukuguquguquka kokulungisa ukusebenza

Inqanaba lokufakwa endaweni (DS kunye ne-KMS) ye-kimbacell®HPMC inokuhlengahlengiswa ngokwemfuno, ngokwenza oko kubushushu bayo, ukubonwa kunye nezinye izinto zokufezekisa iimfuno zobugcisa.

3. Amasimi esetyenziswayo kunye namathemba

I-HPMC inokusetyenziswa njengodaka kunye nomgangatho wamanzi kwicandelo lokwakha, njengearhente yokukhupha iziyobisi kwintsimi yamayeza, kwaye njenge-emulsifier kunye nokuzinza kwishishini lokutya. Ngokuqhubela phambili kwe-chemistry eluhlaza kunye nophuhliso oluzinzileyo, i-synthesi ephantsi kunye nokuphuhliswa kokusebenza okuphezulu kwe-HPMC kuya kuba kukugxila kophando lwexesha elizayo.

I-HydroxyPOpyl Methylcelceltulose iye yaba yinto ebalulekileyo kwaye ibaluleke kakhulu kwishishini lanamhlanje kunye nobomi bemihla ngemihla ngomsebenzi wayo ophezulu kunye nokungabi gwenxa.