I-Polymer yeNdmba yeNdalo i-Holdroxypropyl MethylcelcelceLiase yeSamente esekwe kwisamente

I-HydroxyPOpyl Methylcelcelsele (i-HPMC) yi-polymer yendalo esetyenziswe ngokubanzi kumzi-mveliso wokwakha njengendawo esekwe kwisamente. Ingasetyenziswa njengearhente yokugcina amanzi, i-thi cokener, kunye ne-Binder yokuphucula intsebenzo esekwe kwiplasters esekwe kwisamente.

I-HPMC yi-semi-syntgetic, i-polymer ye-folnemer eyenziwe kwi-sellyulose. Ithathwe kwi-selupese yendalo ngenkqubo yokuhlengahlengiswa kwekhemikhali ebandakanya ukongezwa kwe-hydroxyl kunye namaqela e-methyl. Olu hlengahlengiso lubangela i-polymer ephuculweyo yokuluka kwamanzi, uzinzo lwe-thermal, kunye nokuxhathisa imichiza.

Ukusetyenziswa kwe-HPMC kwifomu esekwe kwisamente kubonelela ngezibonelelo ezininzi ezinje:

1. Ukuphuculwa kokuphuculwa: I-HPMC isebenza njenge-RUOOLOGEROLY ephucula ukusebenza kunye neepropathi zesicelo sodaka. Iphucula umbumbi, ubumbano, kunye nokusasazeka kodaka, ivumela ukuba isetyenziswe ngokulula kwi-subtate.
2. Ukugcinwa kwamanzi okuphuculweyo: I-HPMC inokufumana kwaye igcine inani elikhulu lamanzi, elinceda ukuthintela udaka ukuba lokomisa ngokukhawuleza. Le mpahla iqinisekisa ukuba umhlaba ugcina ukungangqinelani kunye nokusebenza ixesha elide, nokuba kwiimeko ezishushu nezomileyo.
3. Ukunyuka okunyukayo: I-HPMC ivelisa ifilimu ejikeleze amasuntswana e-ceba, ephucula ubumbano lwabo kunye nokunamathela kwindawo. Le mpahla iqinisekisa ukuba i-Plaster ihlala inqabile kwaye ayisebenzi okanye yahlukile kwikhubalo.
4. Ukucuthwa kokuqhekeka: I-HPMC iphucula amandla e-thansile kunye nokuguquguquka kodaka, ukunciphisa amathuba okuqhekeka ngenxa ye-shrinkage okanye ukwanda.
5. Ukuqina okuphuculweyo: I-HPMC ibonelela ngobuqhetseba kunye nokuxhathisa kwamanzi okuphuculweyo kunye nokuxhathisa imichiza, kuyenza kube bomelele kwaye kuxhathise kwimozulu kunye nokwaluphala.

Ukongeza kwezi zibonelelo, i-HPMC ikwayinto enzileyo nenobuhlobo obunokunceda ukunciphisa ifuthe elisekwe kwindalo. Ayisinetyhefu, i-biodegraded, kwaye ayikhuphi nezinto eziyingozi kwindalo esingqongileyo.

Ukusebenzisa i-HPMC kwiPlasters esekwe kwiSamente, ihlala yongezwa kumxube owomileyo wesamente kunye nesanti phambi kombutho wamanzi. Umthamo ocetyiswayo we-HPMC uyahluka ngokuxhomekeke kwisicelo esithile kunye neepropathi ezinqwenelekayo zodaka. Ngokubanzi, idosi ye-0.2% ukuya kwi-0.5% ye-HPMC esekwe kubunzima besamente kunye nesanti iyacetyiswa.

I-HPMC yindawo yokuguquguquka kunye nokusebenza enokuphucula indlela yokusebenza kweplaster esekwe kwisamente. Imvelaphi yayo yendalo, ukuzinza kwayo, kunye ne-EC-Geareelity yenza ukhetho olukhawulezileyo lweekhontraktha, ooyilo, kunye nabanini bodwa ababeka phambili iinkqubo ezizinzileyo zokwakha.