IHydroxypropyl methylcellulose (HPMC) yipolymer esetyenziswa ngokubanzi kumayeza, izithambiso, iimveliso zokutya, kunye nezicelo ezahlukeneyo zamashishini. Izinga layo lokuchithwa linokwahluka ngokuxhomekeka kwizinto ezininzi ezifana nobushushu, i-pH, i-concentration, i-particle size, kunye nebakala elithile le-HPMC elisetyenzisiweyo. Ukuqonda ezi zinto kubalulekile ekwandiseni ukwakheka kwamachiza, ukulawula iiprofayili zokukhutshwa, kunye nokuqinisekisa ukusebenza kakuhle kweemveliso ezahlukeneyo.
1. Intshayelelo kwi-HPMC:
I-HPMC yi-semi-synthetic, inert, ipholima enyibilikayo emanzini ephuma kwiselulosi. Ngokuqhelekileyo isetyenziswa njenge-thickener, i-binder, ifilimu yangaphambili, kunye ne-stabilizer ekuqulunqweni kwamayeza. Enye yeempawu zayo eziphambili kukukwazi ukudumba emanzini, ukwenza into efana nejeli. Le propati iluncedo ekulawuleni amaxabiso okukhutshwa kwechiza kwiifom ezahlukeneyo zedosi ezifana neepilisi, ii-capsules, kunye nokulawulwa kokukhutshwa kwemixube.
2. Imiba echaphazela ukupheliswa kwe-HPMC:
2.1 Ubushushu:
Ubushushu budlala indima ebalulekileyo ekuchithweni kweHPMC. Ngokubanzi, amaqondo obushushu aphezulu akhawulezisa inkqubo yokupheliswa ngenxa yokwanda kwentshukumo yeemolekyuli kunye nokudibana rhoqo. Nangona kunjalo, amaqondo obushushu aphezulu kakhulu anokuthoba i-HPMC, echaphazela i-kinetics yayo yokupheliswa kunye nokusebenza ngokubanzi.
2.2 pH:
I-pH ye-dissolution medium inokuchaphazela ukuchithwa kwe-HPMC ngokuchaphazela imeko yayo ye-ionization kunye nokusebenzisana nezinye iikhompawundi. I-HPMC ikholisa ukubonisa ukunyibilika okulungileyo kuluhlu olubanzi lwe-pH, iyenza ilungele imixube eyahlukeneyo. Nangona kunjalo, iimeko ezigqithisileyo ze-pH zinokutshintsha ukuziphatha kwayo kokuchithwa kunye nokuzinza.
2.3 Ukugxila:
Ukuxinwa kwe-HPMC ekuqulunqweni kuchaphazela ngokuthe ngqo izinga lokuchithwa kwayo. Uxinzelelo oluphezulu luhlala lukhokelela ekunyibilikeni kancinci ngenxa yokwanda kwe-viscosity kunye nokusebenzisana kwepolymer. Abaqulunqi kufuneka benze ulungelelwano phakathi kokufikelela kwi-viscosity efunwayo yokusetyenzwa kunye nokuqinisekisa ukupheliswa okwaneleyo kokukhutshwa kwechiza.
2.4 Ubungakanani beNcam:
Ubungakanani bamasuntswana e-HPMC bunokuchaphazela indawo yabo yomhlaba kunye ne-kinetics yokuchithwa. Amasuntswana acoliweyo athande ukunyibilika ngokukhawuleza kunamasuntswana amakhulu ngenxa yokwanda kwawo kwindawo ukuya kumthamo wevolumu. Ukuhanjiswa kobungakanani besuntswana yiparameter ebaluleke kakhulu ekwandiseni iprofayile yokupheliswa kwe-HPMC-based formulations.
2.5 IBakala le-HPMC:
I-HPMC ifumaneka kumabakala ahlukeneyo anobunzima beemolekyuli ezahlukeneyo kunye namanqanaba okutshintsha. Olu lwahluko lunokuba nefuthe elibonakalayo kwindlela yokuziphatha kwayo yokuchithwa kunye nokusebenza kwimiqulu. Abaqulunqi kufuneka bakhethe ngononophelo ibakala elifanelekileyo le-HPMC ngokusekwe kwiprofayili efunwayo yokukhupha, iimfuno zokusetyenzwa, kunye nokuhambelana nabanye abancedisi.
3. UVavanyo lokupheliswa kwe-HPMC:
Uvavanyo lokuphelisa ngumba obalulekileyo wophuhliso lwamayeza kunye nolawulo lomgangatho. Ibandakanya ukuvavanya umlinganiselo kunye nobungakanani bokukhutshwa kwechiza kwiifom zedosi phantsi kweemeko ezisemgangathweni. Kwimixube esekwe kwi-HPMC, uvavanyo lonyiso lubandakanya ukuntywiliselwa kwifomu yedosi kwindawo yonyibiliko kunye nokubeka esweni ukukhutshwa kwechiza ngokuhamba kwexesha kusetyenziswa iindlela ezifanelekileyo zohlalutyo ezifana ne-UV spectroscopy okanye i-HPLC.
4. Usetyenziso lwe-HPMC:
I-HPMC ifumana usetyenziso olunabileyo kuwo wonke amashishini ahlukeneyo ngenxa yeempawu zayo eziguquguqukayo. Kumashishini amayeza, isetyenziswa kwiipilisi zeepilisi, ukukhutshwa okuzinzileyo, izisombululo ze-ophthalmic, kunye ne-topical creams. Kwizinto zokuthambisa, i-HPMC isetyenziswa kwiimveliso zokhathalelo lomntu ezifana neloshini, iishampu, kunye nejeli ngenxa yokuqina kwayo kunye neziphumo zokuzinzisa. Ukongeza, i-HPMC iqeshwe kwiimveliso zokutya njenge-thickener, emulsifier, kunye ne-ejenti yokugcina ukufuma.
5. Isiphelo:
ukuchithwa kwe-HPMC iphenjelelwa zizinto ezininzi ezibandakanya ubushushu, i-pH, i-concentration, i-particle size, kunye nebakala le-HPMC elisetyenzisiweyo. Ukuqonda le miba kubalulekile ekuqulunqeni iinkqubo zokuhanjiswa kweziyobisi ezisebenzayo, ukulawula iiprofayili zokukhutshwa, kunye nokuqinisekisa umgangatho wemveliso kumashishini ahlukeneyo. Ngokusebenzisa ngokupheleleyo iiparamitha zonyiso kunye nokukhetha ibakala elifanelekileyo le-HPMC, abaqulunqi banakho ukuphuhlisa iifomyula ezintsha ezineempawu zokukhulula ezilungiselelweyo kunye nokusebenza okuphuculweyo.
Ixesha lokuposa: Mar-18-2024