Ngaba amabakala ahlukeneyo e-HPMC awenza njani ngokwahlukileyo?

I-HydroxyPOpyl Methylcelcelsele (i-HPMC) yi-Polymer eguquguqukayo isetyenziswa ngokubanzi kumashishini anje ngamayeza, ukutya, kunye nolwakhiwo. Intsebenzo yayo iyahluka ngokusekwe kumabakala ayo, eyahlukileyo kwimilinganiselo enjengokubonakala kwe-viscofity, isidanga sokufakwa endaweni, nobuncinci be-suricle, nokucoceka. Ukuqonda ukuba la mabakala achaphazela ngayo intsebenzo ibalulekile ekuqhubeni ukusetyenziswa kwayo kwizicelo ezahlukeneyo.

I-1. UVIKISITY

I-Viscosity yipharamitha ebalulekileyo ephembelela intsebenzo ye-HPMC kwizicelo ezahlukeneyo. Ihlala ilinganiswe kwi-cerindises (CP) kwaye inokusukela ukusuka ezantsi ukuya phezulu ukuya phezulu kakhulu.

Amayeza e-Pharmuceuticals: Kwimigaqo yetafile, i-HPMCIty ye-HPMC (umzekelo, i-5-50 cp) ihlala isetyenziswa njenge-binder kuba ibonelela ngexesha elifanelekileyo lokuhlaselwa kwetafile. I-HPMCITY ye-HPMC (umzekelo, i-1000-4000 CP), kwelinye icala, isetyenziswa kwifomu elawulwayo. UVenkile oluphezulu luyacothisa inqanaba lokukhutshwa ngamachiza, ngaloo ndlela bendisa ukusebenza kwamayeza.

Ulwakhiwo: kwiimveliso ezisekwe kwimo yesamente, iphakathi ukuya kwi-HPMC ephezulu (umzekelo, i-100-200,000 cp) isetyenziselwa ukomeleza amanzi kunye nokusebenza. Amabakala e-Viscosity ebonelela ngokugcinwa kwamanzi kwaye aphucule imbethe kunye namandla omxube, abenze balungele ukuba banxibe iimpahla zasendle kunye nokufa.

2. Inqanaba lokufaka

Inqanaba lokufakwa endaweni (DS) libhekisa kwinani lamaqela e-hydroxyl kwimolekyuli esellulose efakwe endaweni ye-FOEXGS okanye amaqela e-hydroxypropy. Olu hlengahlengiso luhlala luyeyona nto, ukungcwaba, kunye neepropathi ze-thermal ye-HPMC.

Ukunyibilikisa: Ixabiso eliphezulu le-DS linyusa uninzi lokuluka kwamanzi. Umzekelo, i-HPMC enendlela ephezulu yendlela yokuphosa inyibilikisi ngakumbi kumanzi abandayo, enokuba yingenelo kumiso-mali yamachiza kunye nesiraphu apho kukho imfuneko yokupheliswa ngokukhawuleza.

I-thermal gall: I-DS ikwachaphazela ubushushu bokuhlaselwa. I-HPMC enenqanaba eliphezulu lokufaka endaweni ye-Gels kwiqondo elingaphantsi, eliyingenelo kwizicelo zokutya apho inokusetyenziswa khona ukwenza ii-geses ezizinzileyo zobushushu. Ngokwahlukileyo, i-DS ye-DS HPMC isetyenziswa kwizicelo ezifuna uzinzo oluphezulu.

I-3. Ubungakanani be-paunticle

Ubungakanani bobungakanani bentsundu ichaphazela ireyithi yokuchitha kunye neepropathi zomzimba zemveliso yokugqibela.

I-PhamaceOuticals: Ubungakanani abancinci be-I-I-HPMC inyibilikisile ngokukhawuleza, iyenza ilungele ukukhululwa ngokukhawuleza. Ngokuchaseneyo, ubungakanani be-partical enkulu busetyenziswa kwiitafile ezikhutshiweyo ezilawulwayo, apho ukutshintshwa kancinci kuyinto enqwenelekayo yokukhutshwa kweziyobisi.

Ulwakhiwo: Kwizicelo zokwakha, amasuntswana aseburhulumenteni ye-HPMC ukuphucula i-homogeneity kunye nokuzinza komxube. Oku kubalulekile ekuqinisekiseni ukungangqinelani okulinganayo kwipeyinti, iingubo, kunye nokubulala.

I-4. Ukucoceka

Ukucoceka kwe-HPMC, ngakumbi malunga nobukho bezinto ezingcolisekileyo ezinjengeentsimbi ezinzima kunye nezinyibilikisi zentsalela, zibalulekile, izezimali zokutya.

Amayeza okutya kunye nokutya: Amanqanaba aphezulu e-HPMC kubalulekile ukuze afezekise imigangatho yolawulo kwaye aqinisekise ukhuseleko. Ukungcola kunokuchaphazela intsebenzo yePolymer kunye nengozi yempilo. I-PharmaceOutical HPMC kufuneka ihambelane nezikhokelo ezingqongqo ezifana nezo zichazwe kwi-pharmacopeapopeas (i-USP, EP) ye-ungcoliseko.

I-5. Umsebenzi osetyenziswayo

Izicelo zamayeza:

Iibhasikisi kunye neefilimu: I-firlers kwi-HPMOTION ye-HPMC ye-HPMC (5-100 CP) zikhethwa njengababizi kunye neefilimu kwiitafile, apho ziphucula khona amandla etafile ngaphandle kokulalanisa.

Ukukhutshwa okuthengisiweyo: Amabakala e-HPMC ePhakamileyo ye-HPMC (i-1000-4000 CP) alungele ukukhululwa okulawulwayo. Benza isithintelo sejeli esikhupha i-modulame ukukhutshwa ngamachiza.

Isisombululo se-Ophthalmimic: Ucoceko oluphezulu, i-HPMCIT ye-HPMC (ngaphantsi kwe-5 cp) isetyenziswa kumahla e-rops ukulungiselela ukubonelela ngolwazi ngaphandle kokucaphukisa.

Ishishini lokutya:

Ii-thi choiners kunye nezilotha: Phantsi kwii-HPMOIUTION ze-HPMC ze-HPMC Baphucula ukuqunjelwa kunye nobomi beShelfice, ukunxiba, kunye nezinto ezibhakayo.

I-fiber ye-fiber: i-HPMC ene-viscofity ephezulu isetyenziswa njengesongezelelo se-fiber kwi-calorie ephantsi, ukubonelela ngesiqwengana se-bulk kunye nokusebenza.

Ishishini lokwakha:

Iimveliso ezisekwe kwi-Gypsim kunye neGypsim: Iphakathi ukuya kwiBanga le-HPMC eliPhakamileyo ye-HPMC (100-200,000 cp) ziqeshwa ukuphucula ukugcinwa kwamanzi, ukusebenza kunye nonamathembulo. Oku kubalulekile kwizicelo ezinjengeetrashes, i-ronders, kunye neeplate.

Iipeyinti kunye neengubo zangaphantsi: Amabakala e-HPMC nge-viscofity efanelekileyo kunye ne-paricle ubungakanani bonyusa i-RUOOOOOLOGL, ukuvelisa, kunye nokuzinza kwepeyinti, okhokelela kubomi obude beshels.

Amabakala ahlukeneyo e-HPMC anikezela ngoluhlu olubanzi lweepropathi ezinokulungelelaniswa kwiimfuno ezithile kumashishini ahlukeneyo. Ukukhetha iBanga-Ukusekela I-Viscosity, isidanga sokufakwa endaweni, ubungakanani be-paricle-udlala indima ebalulekileyo ekwenzeni isicelo esifanelekileyo. Ngokuqondisa ezi zinto, abavelisi banokulikhetha ngcono inqanaba elifanelekileyo le-HPMC ukufezekisa iziphumo ezilungileyo, nokuba zikwimigangatho yamayeza, ukutya, okanye yokwakha. Le ndlela yokulungelelaniswa iqinisekisa ukusebenza ngempumelelo, ukhuseleko, kunye nomgangatho, ibalaselisa ukubaluleka kunye nokubaluleka kwe-HPMC kwizicelo zemveliso.