IHydroxypropyl methylcellulose (HPMC) yipolymer eguquguqukayo efumana izicelo ezibanzi kumashishini ahlukeneyo kubandakanya amayeza, ukutya, izinto zokuthambisa, kunye nokwakha. Enye yeempawu zayo ezizodwa kukukwazi ukwenza iigels phantsi kweemeko ezithile. Ukuqonda ubushushu be-gelation ye-HPMC kubalulekile ekwandiseni ukusetyenziswa kwayo kwizicelo ezahlukeneyo.
Intshayelelo nge-HPMC:
IHydroxypropyl methylcellulose (HPMC) yi-semi-synthetic, inert, i-viscoelastic polymer ephuma kwi-cellulose. Iqhele ukusetyenziswa njenge-thickener, stabilizer, emulsifier, kunye nefilimu yangaphambili ngenxa yeempawu zayo ezibalaseleyo zokwenza ifilimu kunye nokukwazi ukuguqula i-rheology yeenkqubo zamanzi. I-HPMC iyanyibilika emanzini abandayo, kwaye isisombululo sayo i-viscosity ixhomekeke kwizinto ezifana nobunzima be-molecular, degree of substitution, kunye noxinaniso.
Indlela yoGelation:
I-Gelation ibhekisela kwinkqubo apho isisombululo siguqulela kwi-gel, ebonisa ukuziphatha okuqinileyo kunye nokukwazi ukugcina imilo yayo. Kwimeko ye-HPMC, i-gelation iyenzeka ngenkqubo ebangelwa yi-thermal okanye ngokongezwa kwezinye ii-arhente ezinjengeetyuwa.
Izinto ezichaphazela iGelation:
Ukugxila kwe-HPMC: Ukugxila okuphezulu kwe-HPMC ngokubanzi kukhokelela kwi-gelation ekhawulezayo ngenxa yokunyuka kobudlelwane bepolymer-polymer.
Ubunzima beMolekyuli: Ubunzima obuphezulu bemolekyuli ye-HPMC iipolymers zivame ukwenza iigels ngokulula ngenxa yokwanda kwe-entanglements kunye ne-intermolecular interactions.
I-Degree of Substitution: Iqondo lokutshintshwa, elibonisa ubungakanani be-hydroxypropyl kunye ne-methyl substitution kwi-cellulose backbone, ichaphazela ukushisa kwe-gelation. Amanqanaba aphezulu okutshintshwa anokunciphisa ubushushu be-gelation.
Ubukho beeTyuwa: Iityuwa ezithile, ezifana ne-alkali metal chlorides, zinokukhuthaza i-gelation ngokusebenzisana namatyathanga e-polymer.
Ubushushu: Iqondo lobushushu lidlala indima ebalulekileyo kwi-gelation. Njengoko iqondo lokushisa linyuka, amakhonkco e-polymer afumana amandla e-kinetic, aququzelele ukulungiswa kwee-molecular eziyimfuneko ekubunjweni kwegel.
Iqondo lobushushu le-HPMC:
Ubushushu be-gelation ye-HPMC inokwahluka ngokuxhomekeke kwizinto ezininzi ezikhankanywe ngaphambili. Ngokubanzi, iijeli ze-HPMC kumaqondo obushushu angaphezu kwamaqondo obushushu asuka kuma-50°C ukuya kuma-90°C. Nangona kunjalo, olu luhlu lunokwahluka kakhulu ngokuxhomekeke kwibakala elithile le-HPMC, ukugxila kwayo, ubunzima be-molecular, kunye nezinye izinto zokuqulunqa.
Ukusetyenziswa kweeGel zeHPMC:
Amachiza: Iijeli ze-HPMC zisetyenziswa ngokubanzi kuqulunqo lweyeza lokukhutshwa kwechiza elilawulwayo, usetyenziso lwezihloko, nanjengezilungisi ze-viscosity kwiifom zedosi yolwelo.
Ishishini lokutya: Kushishino lokutya, iijeli zeHPMC zisetyenziswa njengezinto ezityebisayo, izizinzisi, kunye neearhente zeegelli kwiimveliso ezahlukeneyo ezifana neesosi, izimuncumuncu, kunye neemveliso zobisi.
Ulwakhiwo: Iijeli ze-HPMC zifumana ukusetyenziswa kwizinto zokwakha ezifana nodaka lwesamente, apho zisebenza njengama-agent okugcina amanzi, ukuphucula ukusebenza kunye nokubambelela.
Izithambiso: Iijeli ze-HPMC zibandakanywe kwizinto zokuthambisa ezifana neekhrimu, izinto zokuthambisa, kunye neemveliso zokhathalelo lweenwele ukwenzela ukujiya kwazo nokuzinzisa iipropati.
iqondo lobushushu gelation of HPMC ixhomekeke kwizinto ezahlukeneyo kuquka yoxinaniso, ubunzima molekyuli, iqondo lokuthatha indawo, kunye nobukho izongezo ezifana neetyuwa. Nangona ukushisa kwe-gelation ngokuqhelekileyo kuwela phakathi kwe-50 ° C ukuya kwi-90 ° C, kunokwahluka kakhulu ngokusekelwe kwiimfuno ezithile zokuqulunqa. Ukuqonda ukuziphatha kwe-gelation ye-HPMC kubalulekile kusetyenziso lwayo oluyimpumelelo kwizicelo ezahlukeneyo kumayeza, ukutya, ulwakhiwo, kunye namashishini wokuthambisa. Uphando olongezelelweyo kwizinto eziphembelela i-HPMC gelation inokukhokelela kuphuhliso lwemixube eyandisiweyo kunye nosetyenziso lwenoveli yale polima iguquguqukayo.
Ixesha lokuposa: Mar-28-2024