I-Ethylcellulose (EC)yindawo ye-semi-symeticatic ye-polymer efunyenwe ngu-ithewutisose ye-sellyul yendalo. Isakhiwo esiqhelekileyo semolekyuli senziwe iiyunithi ze-glucose exhunyiwe yi-β-1,4-Glycosidic Bonds. Ngenxa ye-biomatinigo yayo entle, engabinayo, ukulawulwa okuhle kunye nemithombo emininzi, iselkheese isetyenziswe ngokubanzi kumalungiselelo asemachiza, ngakumbi kumzi-mveliso wamayeza.
1. Iipropathi ezisisiseko ze-Ethyl Selelose
I-Ethyl Selelose inomzimba ophakamileyo kwaye inokubakho emzimbeni womntu ixesha elide ngaphandle kokuvelisa impendulo enetyhefu. Isakhiwo saso sekhemikhali sikunika i-hydrophobility, uzinzo, i-AID no-Alkali ukunganyangeki kunye neepropathi ezithile zolawulo olulawulwayo. Ukongeza, i-Sellyl Selelose emanzini, kodwa inyibilikiswa kwiinyibiliki ezifana ne-ethanol, i-chloroform, i-acetone, njl. Njl. Njl.
2. Ukusetyenziswa kweSellutase kwiSelling kwiSomaceutical Amalungiselelo
Intsimi yesicelo ye-Sellyulose ibanzi kakhulu, egubungela amalungiselelo omlomo, inaliti, amalungiselelo angaphandle kunye neminye imiba emininzi. Oku kulandelayo zizicelo eziphambili zeSethyl Selelose kumalungiselelo e-chimbeceutical.
2.1 Amalungiselelo okukhutshwa kwemvumelwano yomlomo
Esona sicelo siqhelekileyo se-sellyulose ye-Ethyl injengearhente elawulwayo, ngakumbi kumalungiselelo okukhutshwa kweMithetho ngomlomo. Indalo ye-hydrophobic kunye nokulawulwa kwe-ithyl sethyl seluplose kuyenza ibe yinto efanelekileyo yokukhupha iziyobisi. Kumalungiselelo okukhutshwa kweziyobisi, i-Ethyl Secolose inokulibazisa inani lokukhupha ichiza ngokwenza ukuba ifilimu ikhathazekile, emva koko izuze injongo yokwandisa isiphumo seziyobisi. Ngokuhlengahlengisa ubunzima bemoleyuli ye-Ethyl Selelose, ubukhulu becala lonyango kunye nohlobo lwesiselo esikhethiweyo, inqanaba lokukhutshwa kunye nendlela yokukhupha ichiza elinokulawulwa.
I-Ethyl Selelose ihlala isetyenziselwa ukulungiselela iitafile eziqinileyo zomlomo. Ichiza lisongelwe kwifilimu ye-sethyl sethyl secelose. Inkqubo yokukhutshwa ngamachiza inokulawulwa kukudumba kunye nokususwa kwefilimu kunye nokungeniswa kwesinyibilikisi. Ngokutsho kwenkqubo eyahlukeneyo, iimeko zenkqubo, i -thyl sellulose inokulawula ngempumelelo ixesha lokukhululwa kwechiza, ukunciphisa inani lamaxesha odoli, kunye nokuphucula ukuthotyelwa koguli.
2.2 Ifilimu yefilimu yeziyobisi
Kwilungiselelo leziyobisi, i-Ethyl Selelose isetyenziselwa ukuqalisa kwefilimu, ngakumbi kumalungiselelo aqinileyo aqinileyo anjengeetafile, amaqhinga kunye neecaphule. Njengesithuba sokukhathalela ifilimu, i-Ethyl Selelose ineempawu ezintle zefilimu, ezomeleleyo kunye namandla omatshini, ezinokubonelela ngamachiza amachiza kwaye akhubekise iphecana le-gestric acid. Kwangelo xesha, ifilimu ye-Sethyl Selelose inokulawula inqanaba lokukhutshwa kwechiza, ngakumbi ngokuhlengahlengisa ububanzi befilimu kwaye isebenzise izinyibilikisi ezahlukeneyo, i-curves ezahlukileyo zinokufezekiswa.
Njengezinto zokudlala, i-sethyl secelose inokuphucula ukungcamla kwechiza, ukuthintela ubukrakra okanye ukungonwabi, kwaye kwandisa ukwamkelwa kwesigulana.
2.3 I-Emoulsion kunye namalungiselelo e-miller
Ngenxa yokunyibilika kwayo kunye nomsebenzi womhlaba, iselsel sellyulose isetyenziswa ngokubanzi kwi-emulssions kunye namalungiselelo kaMiellar. Kumiliselo lwee-eulssions, i-ethlose, njenge-emulsifier kunye ne-stalsifier, zinokuphucula ngokufanelekileyo ukunyibilikisa kwechiza kwaye zikwandisa ukusebenza kwechiza. Ingakumbi iziyobisi ezinqabileyo zamafutha, i -thyl sethyl sellulose inokunciphisa ichiza kwisigaba se-ACTEACE, inciphise inyama yechiza emanzini, kwaye iphucule i-bioaaaint yeziyobisi.
Kwilungiselelo le-millar, i-Ethyl Selelose, njengesimilo esizinzileyo seziyobisi, sinokuphucula ukunyibilika kunye nokungafumaneki iziyobisi emzimbeni, ngakumbi iziyobisi ezinyibilikayo.
2.4 Ulungiselelo lweziyobisi
I-Kimbacell®ostyl Secolose ikwasetyenziswa ngokubanzi kulungiselelo lweziyobisi, ngakumbi kumalungiselelo eefreyiti, iikhrim, iiglasi kunye namanye amalungiselelo. Njengomthi omkhulu, ifilimu yangaphambili kunye ne-stabilizer, i-sthyl secelose inokuphucula ukusasazeka, ukunamathela kunye nokufana kwamachiza aphezulu. Kumalungiselelo aphezulu anjengee-oftiments kunye nee-crimoms, i-sethyl secelose inokuphucula i-viscofity kunye nokuzinza kwamalungiselelo, aqinisekisa ukuhanjiswa kwe-interm kunye nokukhululwa okuzinzileyo kwechiza ngexesha lokusetyenziswa.
I-2.5 inkqubo yokuthwala iziyobisi
I-Ethyy Seluplose inokusetyenziswa njengoMphaleli weziyobisi, ngakumbi kulungiselelo lwe-nanocarriers kunye ne-microcarerer. I-Ethyl Selelose inokwenza isbus supers ezineemolekyuli zeziyobisi zokubonelela ngolawulo olungcono lokuhambisa iziyobisi. Kwiinkqubo ze-nanocaris, iipropathi ezingaphezulu kweseti ye-Ethyl Selelose inokuphuculwa ngokuguqulwa kwemichiza okanye unyango lokuphucula ukusebenza kweziyobisi kunye nokukhutshwa kwenqanaba lokulawula amachiza.
3. Izibonelelo kunye nemiceli mngeni ye-Ethyl Selelose
Njengommangaliso wamalungiselelo eziyobisi, iKimbacell® yeSellielose ineenzuzo ezininzi. Ine-biomatisises elungileyo kunye ne-biedegradiance, enokunciphisa imiphumo emibi emzimbeni womntu; Inokulawula ngokufanelekileyo ukukhululwa kweziyobisi kunye nokuphucula isiphumo sonyango lweziyobisi; Ukongeza, itekhnoloji yokuqhubela i-Ethyy Seleulose iqolile, isetyenziswe ngokubanzi, ixabisa kakhulu, kwaye ilungele imveliso enkulu. Nangona kunjalo, i-Ethyl Selelose nayo ijongene nemiceli mngeni. Umzekelo, phantsi kwenani elithile le-PH okanye iimeko zobushushu obuphezulu, uzinzo lwe-Ethyy Selelose unokuncitshiswa, olunokuchaphazela isiphumo semisebenzi.
I-Ethyl SeleloseUnoluhlu olubanzi lwamalungelo okusetyenziswa kumalungiselelo amayeza amayeza, ngakumbi kumacandelo okukhutshwa kwe-chie, iifilimu, ii-emuls, kunye namalungiselelo aphezulu. Iipropathi zayo ezilungileyo zomzimba kunye neekhemikhali zenza ukuba ithandeke kumalungiselelo amayeza. Nangona kunjalo, kwizicelo ezenziweyo, kuseyimfuneko ukwenza kwaye kuphuculwe iintlobo ezithile zeziyobisi kunye neefom zokulungiselela ukoyisa imiceli mngeni kuzinzo, ukulawulwa kokukhutshwa kweziyobisi kunye nonyango.
IXESHA LOKUQALA: UJAN-27-2025