HPMC E15 bakeng sa ho roala lithethefatsi

Hydroxypropyl methylcellulose (HPMC) ke polymer e sebelisoang haholo indastering ea meriana. HPMC ke motsoako oa selulose o qhibilihang ka metsing, oo e seng oa ionic o nkiloeng ho selulose. Thepa ea HPMC e ka laoloa ka ho fapanyetsana tekanyo ea substitution (DS), tekanyo ea polymerization (DP), le karolelano ea hydroxypropyl ho methyl substitution. HPMC E15 ke kereiti ea HPMC e nang le DS ea 0.15 le viscosity ea 15 cps ho 20°C.

HPMC E15 e atisa ho sebelisoa e le excipient indastering ea meriana ka lebaka la thepa ea eona e ikhethang. E 'ngoe ea melemo ea mantlha ea HPMC E15 ke bokhoni ba eona ba ho theha filimi e matla, e tenyetsehang le e pepeneneng. Thepa ena e etsa hore e be khetho e ntle haholo bakeng sa tšebeliso ea lisebelisoa tsa ho roala lithethefatsi. Hangata HPMC E15 e sebelisoa e le moemeli oa ho etsa filimi ka liphahlo tsa enteric, tse etselitsoeng ho sireletsa lithethefatsi ho tloha tikolohong ea asiti ea mpa le ho li lokolla sebakeng se nang le alkaline ho feta mala a manyenyane.

Thepa ea ho etsa filimi ea HPMC E15 e ka boela ea sebelisoa ho ntlafatsa tatso le ponahalo ea mefuta ea litekanyetso tsa molomo. HPMC E15 e ka sebelisoa ho pata tatso e babang ea lithethefatsi tse itseng le ho ntlafatsa tatso ea tsona. HPMC E15 e ka boela ea sebelisoa ho fana ka sebaka se benyang, se boreleli ho matlapa le li-capsules, ho etsa hore li khahle bakuli haholoanyane.

Ntle le thepa ea eona ea ho etsa lifilimi, HPMC E15 e boetse ke setlamo se setle le se teteaneng. HPMC E15 e ka sebelisoa ho ntlafatsa thepa ea phallo ea metsoako ea phofo, ho etsa hore ho be bonolo ho hatella matlapa. HPMC E15 e ka boela ea sebelisoa ho ntlafatsa ho tšoana ha matlapa, ho netefatsa hore letlapa le leng le le leng le na le palo e tsitsitseng ea motsoako o sebetsang oa meriana (API).

HPMC E15 e boetse e tsitsitse haholo boteng ba li-acids, metheo, le letsoai, e leng se etsang hore e be mokhethoa ea loketseng bakeng sa ho sebelisoa maemong a mangata a pH. Thepa ena e lumella ts'ebeliso ea HPMC E15 mekhoeng e fapaneng ea phano ea lithethefatsi, ho kenyeletsoa le litlatsetso tsa tokollo e tsitsitseng. HPMC E15 e ka sebelisoa ho laola ho lokolloa ha lithethefatsi ho tloha mefuta e tiileng ea litekanyetso tse kang matlapa le li-capsules. Ka ho fetola khatello ea HPMC E15, sekhahla sa ho lokolloa ha moriana se ka laoloa.

Ha u sebelisa HPMC E15 mefuteng ea meriana, ke habohlokoa ho nahana ka litšebelisano tse ka bang teng le li-excipients tse ling le motsoako o sebetsang oa meriana (API). HPMC E15 e ka sebelisana le li-excipients tse ling, e bakang liphetoho ho thepa ea 'mele ea sebopeho. HPMC E15 e ka boela ea sebelisana le API, e ka amang bioavailability ea eona le sekhahla sa tokollo. Ka hona, ke habohlokoa ho hlahloba ka hloko ho lumellana ha HPMC E15 le li-excipients tse ling le API pele u etsa foromo ea litekanyetso.

Ntle le ts'ebeliso ea eona indastering ea meriana, HPMC E15 e boetse e sebelisoa lits'ebetsong tse ling tse fapaneng. HPMC E15 e sebelisoa indastering ea lijo e le setenya, se tsitsitseng, le emulsifier. E boetse e sebelisoa indastering ea tlhokomelo ea motho e le ntho e tenya le emulsifier ho lotions, li-shampoo, le lihlahisoa tse ling tsa litlolo.

Qetellong, HPMC E15 ke polymer e sebetsang ka mokhoa o fapaneng e nang le mefuta e mengata ea lits'ebetso indastering ea meriana. Lintho tsa eona tse ikhethang, tse kenyelletsang bokhoni ba eona ba ho etsa lifilimi, thepa ea ho tlama le e teteaneng, botsitso maemong a mangata a pH, le bokhoni ba ho laola ho lokolloa ha lithethefatsi, ho etsa hore e be mokhethoa ea loketseng bakeng sa mekhoa e fapaneng ea ho fana ka lithethefatsi. Leha ho le joalo, ke habohlokoa ho hlahloba ka hloko ho lumellana ha HPMC E15 le li-excipients tse ling le API pele u etsa foromo ea litekanyetso.