Hydroxypropyl Methylcellulose (HPMC) ke nonionic cellulose ether e sebelisoang haholo liindastering tse kang kaho, meriana, lijo, litlolo le litlolo. Ho feto-fetoha ha eona ho tsoa mefuteng ea eona e ikhethang ea lik'hemik'hale tse kang ho teteana, ho kopanya, ho etsa lifilimi, ho boloka metsi le ho tlotsa. Limaraka tse fapaneng tsa HPMC li arotsoe haholo ho latela tekanyo ea tsona ea ho fetola (DS) le methoxy le hydroxypropyl content, ho phaella ho viscosity ea tsona, boholo ba likaroloana le bohloeki. Limaraka tsena tse fapaneng tsa HPMC li na le litšobotsi tse fapaneng tsa ts'ebeliso le ts'ebeliso.
1. Methoxy content le hydroxypropyl content
Methoxy le hydroxypropyl substituent content ea HPMC ke ntlha ea bohlokoa e khethollang ts'ebetso ea eona. Ka kakaretso, litaba tsa methoxy tsa HPMC li pakeng tsa 19% le 30%, 'me litaba tsa hydroxypropyl li pakeng tsa 4% le 12%. HPMC e nang le methoxy e phahameng ka kakaretso e na le monyetla o betere le thepa ea ho etsa filimi, athe HPMC e nang le hydroxypropyl e phahameng e na le elasticity e ntle le ho boloka metsi. Litekanyetso tsena li ama ts'ebeliso ea HPMC ka kotloloho. Ka mohlala, indastering ea kaho, methoxy e phahameng e thusa ho ntlafatsa ho boloka metsi le ts'ebetso ea kaho ea seretse; lefapheng la meriana, litaba tse phahameng tsa hydroxypropyl li thusa ho ntlafatsa litšobotsi tsa ho khomarela le ho lokolla lithethefatsi.
2. Sehlopha sa viscosity
HPMC e ka aroloa ka viscosity e tlase, viscosity e bohareng le limaraka tse phahameng tsa viscosity ho latela viscosity ea tharollo ea eona. Viscosity ke thepa ea bohlokoa ea 'mele ea HPMC, hangata e lekanngoa ka viscosity e bonahalang ea tharollo ea 2% ka metsotsoana ea milliPascal (mPa.s).
Low viscosity HPMC (jwalo ka 5 mPa.s to 100 mPa.s): Mofuta ona wa HPMC hangata o sebediswa ditirisong tse hlokang ho fokotsa matla, jwalo ka marothodi a mahlo, difafatsi le ditlolo. Lits'ebetsong tsena, HPMC ea viscosity e tlase e ka fana ka metsi a mangata le kabo e tšoanang.
Bohareng ba viscosity HPMC (mohlala 400 mPa.s ho 2000 mPa.s): Medium viscosity HPMC e atisa ho sebelisoa ka thepa ea mohaho, li-emulsion le li-adhesives ho fana ka liphello tse lekaneng tse teteaneng, tse ka leka-lekanya ts'ebetso ea kaho le matla a 'mele a sehlahisoa sa ho qetela.
High viscosity HPMC (mohlala 4000 mPa.s ho 200,000 mPa.s): High viscosity HPMC e sebelisoa haholo-holo lits'ebetsong tse hlokang ho tenya ho hoholo, joalo ka seretse, putty, likhomaretsi tsa lithaele le lirafshoa. Ka lihlahisoa tsena, viscosity e phahameng ea HPMC e thusa ho ntlafatsa ho boloka metsi, ho thibela ho fokotseha le matla a ho kopanya.
3. Boholo ba likaroloana
Boholo ba karoloana ea HPMC bo boetse bo ama phello ea ts'ebeliso ea eona. Ka kakaretso, HPMC e ka aroloa ka likaroloana tse mahoashe le likaroloana tse ntle. Coarse particle HPMC e atisa ho sebelisoa lits'ebetsong tse hlokang ho qhibiliha kapa ho hasana ka potlako, ha karolo e ntle ea HPMC e loketse lihlahisoa tse nang le litlhoko tse phahameng tsa ponahalo kapa tse hlokang kabo e tšoanang.
HPMC e mahoashe: HPMC e nang le likaroloana tse kholoanyane e na le lebelo la ho qhibiliha ka potlako ka seretse se omileng se tsoakiloeng le masimo a mang, 'me e ka potlakela ho theha tharollo e ts'oanang, kahoo e ntlafatsa katleho ea tlhahiso.
Fine-grained HPMC: Fine-grained HPMC e sebelisoa haholo liindastering tse kang lipente, litlolo le litlolo. E ka etsa lera le tšoanang la filimi nakong ea ts'ebetso ea kopo, ho ntlafatsa khanya le maikutlo a sehlahisoa.
4. Bohloeki le limaraka tse khethehileng
Ho latela litlhoko tse fapaneng tsa ts'ebeliso, HPMC e ka boela ea hloekisoa kapa ea sebelisoa. HPMC e nang le bohloeki bo phahameng hangata e sebelisoa indastering ea meriana le ea lijo ho netefatsa polokeho le biocompatibility ea sehlahisoa. Ho phaella moo, ho na le tse ling tsa HPMC tse nang le mesebetsi e khethehileng, e kang HPMC e amanang le sefapano, HPMC e tšoaroang holimo, joalo-joalo Limaraka tsena tse khethehileng tsa HPMC li ka fana ka khanyetso e phahameng ea ho ruruha, thepa e matla ea ho etsa filimi kapa acid e molemo le ho hanyetsa alkali.
Pharmaceutical grade HPMC: Pharmaceutical grade HPMC e na le bohloeki bo phahameng 'me e loketse matlapa, li-capsules le litokisetso tse tsoelang pele tsa ho lokolloa, tse ka ntlafatsang haholo tekanyo ea ho lokolloa le botsitso ba lithethefatsi.
Kereiti ea lijo HPMC: Kereiti ea lijo HPMC e sebelisoa e le setenya sa lijo, stabilizer le emulsifier ho netefatsa polokeho le tatso ea lijo.
HPMC ea boemo ba indasteri: HPMC e sebelisoang kahong, liphahlo le masimo a mang e kanna ea ba le litšila tse nyane, empa e ka fana ka moruo o phahameng le ts'ebetso e ntle ea ts'ebetso.
5. Libaka tsa kopo le khetho
Limaraka tse fapaneng tsa HPMC li sebelisoa haholo kahong, meriana, lijo, litlolo le masimo a mang. Ha u khetha sehlopha se nepahetseng sa HPMC, lintlha tse kang viscosity, substituent content, particle size le bohloeki li lokela ho nkoa ho latela litlhoko tsa likopo tse khethehileng.
Sebaka sa kaho: Lisebelisoa tsa moaho, HPMC e sebelisoa haholo joalo ka sekontiri, se bolokang metsi le se tlamang. Bakeng sa lits'ebetso tse kang seretse se omeletseng le likhomaretsi tsa lithaele, ke senotlolo sa ho khetha HPMC e nang le viscosity e nepahetseng le ho boloka metsi.
Tšimo ea meriana: Litokisetsong tsa meriana, HPMC e sebelisoa e le thepa ea khetla ea capsule, ho roala letlapa le sekhomaretsi. Hoa hlokahala ho khetha limaraka tsa HPMC ka ts'ebetso e nepahetseng ea tokollo ea lithethefatsi le biocompatibility.
Lijo le litlolo: Lefapheng la lijo le litlolo, HPMC e sebelisoa e le motenya le botsitso, 'me bohloeki ba eona le polokeho ke tsona lintho tse ka sehloohong tseo ho nahanoang ka tsona.
Limaraka tse fapaneng tsa Hydroxypropyl Methylcellulose (HPMC) li na le melemo ea tsona le boholo bo sebetsang lits'ebetsong. Ho utloisisa le ho khetha sehlopha se nepahetseng sa HPMC ho ka ntlafatsa ts'ebetso le boleng ba sehlahisoa ka nepo le ho fihlela litlhoko tsa lihlahisoa tse fapaneng tsa indasteri le bareki.
Nako ea poso: Aug-21-2024