Hydroxypropylcellulose (HPC) inowanzoshandiswa mumishonga yemishonga mukugadzirwa kwekumiswa. Kumiswa masisitimu akasiyana-siyana anosanganisira zvimedu zvakasimba zvakaparadzirwa mumotokari yemvura. Aya magadzirirwo anoshandiswa zvakanyanya mumishonga yekuendesa mishonga isinganyungudika kana isina kugadzikana mumhinduro. HPC inoshanda akati wandei akakosha mabasa mukumiswa mafomu, ichibatsira mukugadzikana kwavo, viscosity, uye kuita kwese.
1. Nhanganyaya yeHydroxypropylcellulose (HPC):
Hydroxypropylcellulose inotorwa neselulosi inotorwa nekugadziriswa kwekemikari ye cellulose kuburikidza nekuunzwa kwemapoka ehydroxypropyl pamusana we cellulose. Inoshandiswa zvakanyanya mumishonga semushonga nekuda kweiyo yakanaka midziyo yakadai sekunyungudika mumvura uye organic zvinonyungudutsa, biodegradability, firimu-kugadzira kugona, uye kuenderana nemamwe maexcipient uye anoshanda emishonga emishonga (APIs).
2. Basa reHPC mukumisikidza Magadzirirwo:
Mukumisa mafomu, HPC inoshanda akawanda mabasa:
a. Suspension Stabilization:
Rimwe remabasa ekutanga eHPC mukumisikidza kudzikamisa akapararira akasimba masitadhi. Inoita izvi nekugadzira chidziviriro chakatenderedza zvimedu, zvichidzidzivirira kubva pakuunganidza kana kugadzika. Uku kudzikamisa kwakakosha pakuchengetedza kufanana uye kuenderana kwekumiswa kwehupenyu hwayo hwesherufu.
b. Viscosity Kugadziriswa:
HPC inogona kukanganisa zvakanyanya viscosity yekumiswa. Nekugadzirisa kusangana kweHPC mukuumbwa, iyo viscosity inogona kugadzirwa kuti iwane inodiwa rheological properties. Viscosity yakakodzera inovimbisa kumiswa kwakakwana kwezvimedu zvakasimba uye kureruka kwekudira uye dosing.
c. Kuvandudzwa Kwekudurura uye Redispersibility:
HPC inosimudzira kudurura kwekumiswa, zvichiita kuti zvive nyore kudurura uye kutonga. Pamusoro pezvo, inobatsira mukuparadzirazve zvimedu kana kumiswa kunozununguswa kana kuzununguswa, kuve nechokwadi chekufanana uye kuenderana pamusoro pekutonga.
d. Kuenderana uye Kugadzikana:
HPC inoenderana neyakasiyana siyana yemishonga yemishonga uye excipients. Chimiro chayo chine inert uye kushaya reactivity inoita kuti ive yakakodzera kushandiswa mumhando dzakasiyana-siyana. Uyezve, HPC inobatsira kugadzikana kwekumiswa nekudzivirira kupatsanurwa kwechikamu, sedimentation, kana kukura kwekristaro.
3. Mechanism of Action yeHPC muKumiswa:
Iyo meshini inoshandiswa neHPC mukumisikidza inosanganisira kudyidzana kwayo nezvose zvakasimba zvimedu uye mota yemvura. Pakupararira muchikamu chemvura, HPC mamorekuru anoumba matatu-dimensional network kuburikidza nehydrogen bonding uye polymer entanglement. Iyi network inoputira zvimedu zvakasimba, kudzivirira kuungana kwavo uye kugadzirisa. Iyo viscosity yekumisikidzwa inopesvedzerwa nekutarisa uye molecular uremu hweHPC, ine yakanyanya kuwanda uye mamorekuru uremu zvichikonzera kuwedzera viscosity.
4. Zvikumbiro zveHPC muKumiswa Kwemishonga:
Hydroxypropylcellulose inowana kushandiswa kwakakura mumhando dzakasiyana dzekumiswa kwemishonga, kusanganisira:
a. Oral Suspensions:
HPC inowanzo shandiswa mukumisikidzwa nemuromo kugadzira zvinodhaka zvisinganyunguriki zvekutonga nemuromo. Inonatsiridza kunyungudika uye bioavailability yezvishandiso zvinoshandiswa uku uchivimbisa kupararira kweyunifomu uye kurongeka kwedosi.
b. Topical Suspensions:
Mukumisikidzwa kwepamusoro, HPC inoshanda semumiriri wekumisa zvinodhaka zvisinganyunguriki kana zvisina kunyungudika zvakagadzirirwa kuburitsa dermal kana transdermal. Inopa viscosity kune kugadzirwa, kuwedzera kupararira kwayo uye kunamatira paganda.
c. Ophthalmic Suspensions:
Nekumisikidzwa kwemaziso, HPC inoshandiswa kudzikamisa zvikamu zvakapararira uye kuchengetedza kugovera kwavo yunifomu mukudonha kweziso. Iyo biocompatibility uye isiri-inogumbura zvimiro inoita kuti ive yakakodzera kushandiswa kwemaziso.
d. Parenteral Suspensions:
Mukumisikidzwa kwevabereki, uko majekiseni anogadzirwa anodiwa, HPC inogona kushandiswa sechinhu chinodzikamisa. Zvisinei, kushandiswa kwayo mukugadzirwa kwevabereki kunogumira nekuda kwekufunga nezvekuchengetedza uye kuenderana nemaitiro ejekiseni.
5. Mhedziso:
Hydroxypropylcellulose (HPC) inoshandiswa zvakasiyana-siyana mishonga yemishonga inoshandiswa zvakanyanya mukugadzirwa kwekumiswa. Kugona kwayo kudzikamisa zvimedu zvakapararira, kugadzirisa viscosity, kunatsiridza kudurura, uye kuwedzera kuenderana kunoita kuti ive yakakosha mukugadzirwa kwekumisikidzwa kwemuromo, topical, ophthalmic, uye dzimwe nzira dzekutonga. Kunzwisisa basa uye maitiro ekuita kweHPC mukumiswa kwakakosha pakugadzirwa kwemishonga inoshanda uye yakagadzikana yemishonga. Sezvo tsvagiridzo uye tekinoroji zvichiramba zvichifambira mberi, kushandiswa kweHPC mukumiswa kwemishonga kungango shanduka, zvichipa mimwe mikana yekuvandudza nekuvandudza muhurongwa hwekuunza zvinodhaka.
Nguva yekutumira: Mar-27-2024