Hydroxypropyl methylcellulose (HPMC) is semi-synthetic, mvura-soluble polima inotorwa kubva muselulosi. Inoshandiswa zvakanyanya mumaindasitiri akasiyana siyana, anosanganisira emishonga, chikafu, kuvaka, uye zvizorwa, nekuda kwezvakasiyana zvivakwa zvakaita sekukora, kusunga, kugadzira firimu, uye kudzikamisa. Nekudaro, zvakakosha kuti uzive kuti HPMC haina chaiyo yekunyungudika nekuti haiite yechokwadi yekunyunguduka senge crystalline zvinhu. Pane kudaro, inopinda mukupisa kwekupisa kana ichipisa.
1. Zvivakwa zveHPMC:
HPMC ichena kusvika-chena isina hwema hupfu, inonyungudika mumvura uye yakawanda organic solvents. Zvimiro zvaro zvinosiyana zvichienderana nezvinhu zvakaita sedhigirii rekutsiva (DS), uremu hwemamorekuru, uye kugovera saizi yechikamu. Kazhinji, inoratidza zvinotevera maitiro:
Non-ionic nature: HPMC haitakuri chero magetsi ekugadzirisa, zvichiita kuti ienderane nehuwandu hwezvimwe zvinhu.
Kugadzira firimu: HPMC inogona kuumba akajeka, anochinjika mafirimu kana aoma, ayo anowana manyorerwo mumajasi, mafirimu, uye anodzorwa-kuburitsa dosage mafomu mumishonga.
Thickening agent: Inopa viscosity kune zvigadziriso, zvichiita kuti zvive zvakakosha muzvigadzirwa zvekudya, zvekuzora, uye mishonga.
Hydrophilic: HPMC ine hukama hwepamusoro hwemvura, iyo inobatsira mukunyungudika kwayo uye kugadzira firimu.
2. Synthesis yeHPMC:
HPMC inogadzirwa kuburikidza nekutevedzana kwemakemikari maitiro anosanganisira cellulose, propylene oxide, uye methyl chloride. Maitiro acho anosanganisira etherification ye cellulose ine propylene oxide inoteverwa nemethylation ine methyl chloride. Iyo dhigirii yekutsiva (DS) yehydroxypropyl uye methoxy mapoka anogona kudzorwa kugadzirisa zvimiro zveiyo HPMC inoguma.
3. Zvishandiso zveHPMC:
Indasitiri yemishonga: HPMC inoshandiswa zvakanyanya sechinhu chinobatsira mukugadzirwa kwemishonga, kusanganisira mahwendefa, capsules, ophthalmic mhinduro, uye inodzorwa-yekuburitsa dosage mafomu.
Indasitiri yechikafu: Inoshandiswa seyakakora, inosimbisa, uye emulsifier muzvigadzirwa zvekudya zvakaita sesosi, soups, ice cream, uye zvinhu zvekubheka.
Indasitiri yekuvaka: HPMC inowedzerwa kune zvigadzirwa-simende kuvandudza kushanda, kuchengetedza mvura, uye kunamatira. Inoshandiswawo mumatairi anonamira, dhaka, uye renders.
Indasitiri yezvizoro: HPMC inoshandiswa mumhando dzakasiyana dzezvizoro senge makirimu, lotions, uye shampoos nekuda kwekukora uye kudzikamisa zvivakwa.
4. Kupisa kwemaitiro eHPMC:
Sezvambotaurwa, HPMC haina chaiyo yekunyungudika nekuda kwehunhu hwayo hweamorphous. Pane kudaro, inopinda mukupisa kwekupisa kana ichipisa. Iyo degradation maitiro anosanganisira kutyorwa kwemakemikari zvisungo mukati mepolymer cheni, zvichitungamira mukuumbwa kwezvinhu zvinoparara zvekuora zvigadzirwa.
The degradation tembiricha yeHPMC inotsamira pane akati wandei zvinhu, kusanganisira ayo mamorekuru huremu, dhigirii rekutsiva, uye kuvapo kwezvinowedzera. Kazhinji, kupisa kwekupisa kweHPMC kunotanga kutenderedza 200 ° C uye kunofambira mberi nekuwedzera tembiricha. Iyo degradation mbiri inogona kusiyanisa zvakanyanya zvichienderana negiredhi chairo reHPMC uye mwero wekupisa.
Munguva yekupisa kwekupisa, HPMC inopinda maitiro akati wandei, kusanganisira kupera mvura mumuviri, depolymerization, uye kuparara kwemapoka anoshanda. Zvigadzirwa zvikuru zvekuora zvinosanganisira mvura, kabhoni dhaibhoni, kabhoni monoxide, methanol, uye akasiyana mahydrocarbon.
5. Thermal Analysis Techniques yeHPMC:
Thermal maitiro eHPMC anogona kudzidzwa uchishandisa akasiyana analytical matekiniki, anosanganisira:
Thermogravimetric analysis (TGA): TGA inoyera kurasikirwa kwehuremu hwemuenzaniso sekushanda kwekushisa, ichipa ruzivo pamusoro pekugadzikana kwayo kwekushisa uye kuora kinetics.
Differential scanning calorimetry (DSC): DSC inoyera kuyerera kwekushisa kupinda kana kubuda mumuenzaniso sekushanda kwekushisa, zvichibvumira kuratidzwa kwechikamu chekuchinja uye zviitiko zvinopisa zvakadai sekunyunguduka uye kuora.
Fourier-transform infrared spectroscopy (FTIR): FTIR inogona kushandiswa kutarisa shanduko yemakemikari muHPMC panguva yekuora kwemafuta nekuongorora shanduko mumapoka anoshanda uye chimiro chemolecular.
6. Mhedziso:
HPMC ipolymer inoshanda zvakasiyana-siyana ine huwandu hwakawanda hwekushandisa mumishonga, chikafu, kuvaka, uye zvizorwa. Kusiyana nezvinhu zvekristaro, HPMC haina nzvimbo yekunyungudika asi inodzikisira kupisa kana ichipisa. Tembiricha yekushatisa inoenderana nezvinhu zvakasiyana uye kazhinji inotanga kutenderera 200 ° C. Kunzwisisa maitiro ekupisa kweHPMC kwakakosha pakubata kwayo uye kugadzirisa mumaindasitiri akasiyana.
Nguva yekutumira: Mar-09-2024