HPMC (Hydroxypropyl Methylcellulose) chinhu chakawanda chinoshanda chinoshandiswa zvakanyanya mumishonga, chikafu, zvekuvaka nezvimwe minda. Zvigadzirwa zveHPMC zvinogona kukamurwa kuita akawanda akatevedzana zvichienderana neakasiyana mashandisirwo ezvinodiwa, pakati peayo akajairika ari K akatevedzana uye E akatevedzana. Kunyangwe ese ari maviri ari HPMC, ane mimwe misiyano muchimiro chemakemikari, zvimiro zvemuviri uye minda yekushandisa.
1. Kusiyana mukugadzirwa kwemakemikari
Methoxy zvemukati: Musiyano mukuru pakati peK akatevedzana uye E akateedzana HPMC ndeye yavo methoxy zvemukati. Iyo methoxy yemukati yeE yakatevedzana HPMC yakakwira (kazhinji 28-30%), nepo methoxy yemukati yeK yakatevedzana yakadzikira (angangoita 19-24%).
Hydroxypropoxy content: Kusiyana neizvi, iyo hydroxypropoxy yemukati yeK yakatevedzana (7-12%) yakakwira kupfuura iyo yeE series (4-7.5%). Uyu musiyano mukugadzirwa kwemakemikari unotungamirira kune kusiyana kwekuita uye kushandiswa pakati pezviviri.
2. Kusiyana kwezvinhu zvemuviri
Solubility: Nekuda kwemusiyano mune methoxy uye hydroxypropoxy zvemukati, solubility yeK yakatevedzana HPMC yakadzikira zvishoma pane iyo yeE nhevedzano, kunyanya mumvura inotonhora. Iyo E yakatevedzana inonyanya kunyungudika mumvura inotonhora nekuda kweiyo yepamusoro methoxy yemukati.
Tembiricha yeGel: Iyo tembiricha yegel yeK yakateedzana yakakwira kupfuura iyo yeE yakatevedzana. Izvi zvinoreva kuti pasi pemamiriro akafanana, zvakanyanya kuomera K akateedzana HPMC kugadzira gel. Iyo tembiricha yegel yeE yakatevedzana yakadzikira, uye mune mamwe chaiwo maapplication, senge thermosensitive gel zvinhu, E akateedzana anogona kuita zvirinani.
Viscosity: Kunyangwe viscosity inonyanya kuenderana nehuremu hwemamorekuru eHPMC, pasi pemamiriro akafanana, viscosity yeE series HPMC inowanzokwira kupfuura yeK series. Musiyano we viscosity une hunhu hunokosha pane rheological properties panguva yegadziriro yekugadzirira, kunyanya kana inoshandiswa kune machira uye kumiswa.
3. Misiyano mundima dzekushandisa
Nekuda kwekusiyana kwechimiro chemakemikari uye zvemuviri zvimiro zveK akateedzana uye E akateedzana HPMC, mashandisiro avo muminda akasiyana zvakare akasiyana.
Pharmaceutical field: Mukugadzirira kwemishonga, E series HPMC inowanzo shandiswa sechinhu chikuru chekugadzirira-kusunungurwa kwegadziriro. Izvi zvinokonzerwa nekudzikira kwayo gelation tembiricha uye yakakwirira viscosity, izvo zvinoita kuti ikwanise kudzora zvirinani mwero wekuburitswa kwezvinodhaka paunenge uchigadzira mushonga unoburitswa-kuburitswa firimu. Iyo K yakatevedzana inonyanya kushandiswa kune enteric-yakavharwa mapiritsi uye se capsule madziro zvinhu, nekuti yayo yakakwirira gelation tembiricha inodzivisa kuburitswa kwemishonga mugastric juice, iyo inobatsira kuburitswa kwemishonga muura.
Munda wekudya: Muindasitiri yechikafu, E yakatevedzana HPMC inowanzo shandiswa seyakakora, inosimbisa uye emulsifier. Nekuda kwekunyungudika kwayo uye kwakakodzera viscosity, inogona kuparadzirwa zviri nani uye kunyungudika mukudya. Iyo K yakatevedzana inonyanya kushandiswa muzvikafu zvinoda kuchengetedza kugadzikana pasi pemamiriro ekushisa kwepamusoro, senge zvigadzirwa zvakabikwa, nekuda kwekupisa kwayo kwegelation.
Munda wezvivakwa zvekuvaka: Muzvivakwa zvekuvaka, K yakatevedzana HPMC inowanzo shandiswa mudhaka rakaoma uye putty poda, ichiita senge inochengetedza mvura uye inokora, kunyanya kune zviitiko zvinoda kuvakwa pakupisa kwakanyanya. Iwo E akateedzana akanyanya kukodzera kune zvigadzirwa zvine yakakwira rheological properties senge pendi yepasi uye machira nekuda kwekudzika kwayo gelation tembiricha uye yakakwirira viscosity.
4. Zvimwe zvinofurira
Pamusoro pemisiyano iri pamusoro, iyo chaiyo inoshandiswa kweakasiyana akateedzana yeHPMC inogona zvakare kukanganiswa nezvinhu zvakaita semamorekuru huremu, dhigirii rekutsiva, uye dispersibility. Uye zvakare, mukushandisa zvinoshanda, kusarudzwa kweHPMC kunodawo kufunga nezvekuenderana kwayo nezvimwe zvinongedzo uye nemhedzisiro yayo pakuita kwechigadzirwa chekupedzisira.
Kunyangwe iyo K yakatevedzana uye E yakatevedzana yeHPMC ese ari hydroxypropyl methylcellulose, anoratidza mutsauko uri pachena mune zvemuviri zvivakwa uye nzvimbo dzekushandisa nekuda kwezvakasiyana zvemukati methoxy uye hydroxypropoxy mapoka. Kunzwisisa misiyano iyi kwakakosha pakusarudza iyo chaiyo mhando yeHPMC mune inoshanda maapplication.
Nguva yekutumira: Aug-13-2024