Hydroxyprupyl methylcellose (HPMC)inzvimbo ine mvura-yemvura inoshandiswa zvakanyanya muzvivakwa zvekuvaka, mishonga yemishonga, chikafu uye maindasitiri emakemikari. HPMC ine yakanaka kuremerwa, yekuchengetwa kwemvura, firimu-inoumba uye inosanganisira zvinhu, uye inonyanya kukosha mumasimende-yakavakirwa uye yeGypsum zvigadzirwa. Maitiro ekunyungudutswa ekimacell®hpmc mumvura anokanganiswa nezvinhu zvakawanda, pakati pekunonoka kwekunonoka, kunyanya muindasitiri yekuvaka, iyo inosarudza maitiro ekuvaka uye fungidziro yekuvaka, fungidziro uye zvimwe zvigadzirwa. Naizvozvo, kudzidza iyo yekunonoka kunonoka kweHPMC ndeye kukosha kukuru kwekugadzirisa zvinhu zvekunyama.
1. HPMC hydration kunonoka mechani
Kupararira kweHPMC mumvura kunosanganisira matanho mana: Special Welting, Partle kupararira, kuzvimba uye kupaza. Kana magungano akajairwa ari kutaurirana zvakananga nemvura, nzvimbo yepasi inokurumidza kutora mvura kuti iite denderedzwa rezvikamu zvemukati, nekudaro achiratidza kusagadzikana kwekunonoka. Kuti vave nekuvandudza basa rekuvaka, zvimwe zvigadzirwa zveHPMC zvinobatwa zvakanyanya, zvakadai sekuregedza kana kuunganidza kurapwa, kuenderera mberi nekuwedzera nguva yekuvharira uye nekuvandudza nguva yakavhurika uye yekuvhenekera panguva yekuvaka.
Izvo zvinhu zvikuru zvinokanganisa kunonoka kwehydration kunosanganisira:
Particle Saizi Kugovera: Makakura makuru anodzungudza zvishoma zvishoma kupfuura zvidiki zvidiki, uye nguva yekudzokorora nguva yakareba.
Kurapa kwepasi: Mamwe maHPMCs ari kuyambuka-yakabatana kana hydrophobically coated, inogona kunonoka zvakanyanya hydration.
Solution tembiricha
Solvent System: Electrolytes, PH Kukosha uye mamwe mahombe anokwanisa kukanganisa iyo yekunyungudika chiyero uye hydration kunonoka nguva yeHPMC.
2. Kuedza kugadzirwa uye nzira
2.1 Kuedza Zvinhu
HPMC samples (dzakasiyana viscokities, dzakasiyana nzvimbo dzekurapa dzemhando)
Mvura yakadzika
Kusimudzira mudziyo
Viscometer (senge rotivational parcometer)
Laser Partle Saizi Analer
2.2 nhanho dzekuyedza
Kutsunga kwehydration kunonoka nguva
Pasi pekudziya nguva dzose (25 ℃), imwe huwandu hwekimacell®hpmc yakadzikira mumvura isina kumutsa, uye nguva inodiwa kuti ive nzvimbo uye iyo nguva inodiwa kuti zvidimbu zviwedzere kunyatsocherechedzwa.
Viscosity inoshandura kuyerwa
Iyo yekugadzirisa viscosity yakayerwa maminitsi mashanu ega ega uchishandisa rotcational parcometer yekunyora zvishoma nezvishoma kuputswa kweiyo HPMC zvikamu zveHPMC.
Solubility test
Sampling yakaitwa panguva dzakasiyana nguva mapoinzi, uye zvimedu zvisingabvumirwe zvakaparadzaniswa neyefa membrane kuti isarudze maitiro ekugadzirisa nguva nenguva.
Kuongorora Saizi Kuongorora
A laser chidimbu chekutanga chichiongorora kuti chishandurwe chekushandurwa muhukuru hwekuparadzira HPMC zvikamu zveHPMC panguva yeHydration process yekuongorora mhedzisiro yekunonoka kwehydration kunonoka kwehydration kunonoka kwehydration kunonoka.
3. Mhedzisiro uye kuongororwa
Mhedzisiro yebvunzo inoratidza kuti HPMC ine akasiyana viscosity mamakisi uye nzira dzekurapa dzine nzira dzakasiyana dzehyration yekunonoka maitiro. HPMC pasina kurapwa kwepasi nekukurumidza inogadzira gel layer mumvura, nepo hpmc ine yakakosha kurapwa ine yakanyanya kunonoka kunonoka kuyamwa nguva uye yakawanda yunifomu.
Mhedzisiro yeViscosity pane Hydration Kunonoka
Low-viscosity HPMC zvidimbu zvine mupfupi hydration kunonoka nguva nekuda kwehuremu hwavo hwemanyorerwo; Yakakwira-viscosity HPMC ine nguva yakareba yekudzokorora nguva nekuda kweiyo refu-keteni molecular chimiro.
Mhedzisiro yeMusoro Kurapwa pane Hydration Kunonoka
HPMC zvidimbu zvakabatwa ne hydrophobic coating yakadzora zvakanyanya mumvura, uye iyo yekunonoka nguva yekunonoka inogona kuwedzeredzwa kusvika pamaminitsi gumi nemashanu.
Mhedzisiro yeChikamu Chikuru Kugoverwa
Makanaka manhamba ane pfupi pfupi yekudzokorora nguva yekudzokorora, nepo zvikamu zvakakura zvine yakakosha hydration kunonoka nekuda kwesimba remvura ine pasi peganda.
Kusarudzwa zvine musoro kweHpcinogona kugadzirira mashandisiro ayo mukuvaka uye mamwe maindasitiri, kugadzirisa maitiro ekuvaka uye kudzikama. Ichi chidzidzo chinogona kupa ngozi yesainzi yeiyo application optimization yeHPMC uye kutungamira chigadzirwa chekuvandudza kwechigadzirwa uye kugadziriswa kwekugadzirisa
Kutumira Nguva: Kukadzi-21-2025