Hydroxypropyl Methylcellulose (HPMC) ningirakamaro ya selile ikomoka hamwe ninganda nyinshi zikoreshwa mubikorwa byinshi. Ifite ibintu byiza cyane byumubiri nubumara, uburozi buke, hamwe n’ibidukikije.
1. Ibintu shingiro bya HPMC
Imiterere yimiti nibintu bifatika
HPMC ni selile itari ionic ether yabonetse muguhindura imiti ya selile naturel. Imiterere yibanze igizwe na glucose ibice, bigizwe no gusimbuza amatsinda amwe ya hydroxyl hamwe na hydroxypropyl na methyl. Imiterere yumubiri ahanini ni ifu yera cyangwa yoroheje yumuhondo, byoroshye gushonga mumazi akonje kandi ashyushye kugirango bibe igisubizo kibonerana cyangwa cyoroshye cyane.
Uburemere bwa molekulari: HPMC ifite uburemere butandukanye bwa molekile, kuva muburemere buke bwa molekile (nka 10,000 Da) kugeza kuburemere buke (nka 150.000 Da), kandi imiterere yabyo hamwe nibisabwa nabyo birahinduka.
Gukemura: HPMC ikora igisubizo cya colloidal mumazi akonje, ariko ntigishobora gukemuka mumashanyarazi amwe n'amwe, kandi ifite igisubizo cyiza kandi gihamye.
Viscosity: Viscosity numutungo wingenzi wa HPMC, wibasiwe nuburemere bwa molekile nubwoko numubare wabasimbuye. Ubusanzwe-HPMC ikoreshwa cyane nkibyimbye na stabilisateur, mugihe HPMC ifite ubukana buke ikoreshwa mugukora firime no guhuza ibikorwa.
Imiti ihamye
HPMC ifite imiti ihamye, irashobora kurwanya isuri ya acide, alkalis hamwe nudukoko dusanzwe, kandi ntabwo byoroshye kubora cyangwa gutesha agaciro. Ibi birayemerera gukomeza imirimo yayo mubidukikije bigoye kandi birakwiriye muburyo butandukanye bwo gukoresha inganda.
Ibinyabuzima
Kubera ko HPMC ikomoka kuri selile naturel kandi ikaba yarahinduwe kuburyo bugereranije, ifite biocompatibilité nziza nuburozi buke. Kubwibyo, ikoreshwa kenshi mubiribwa, ubuvuzi no kwisiga, byujuje ibisabwa byumutekano.
2. Uburyo bwo gutegura HPMC
Gutegura HPMC mubisanzwe bigabanyijemo intambwe eshatu:
Kuvura alkali: selile isanzwe ivurwa n'umuti wa alkali (ubusanzwe hydroxide ya sodium) kugirango ubyimbye kandi byongere imbaraga.
Imyitwarire ya Etherification: Mugihe cya alkaline, selile ikora reaction ya etherification hamwe na methyl chloride na okiside ya propylene, ikazana amatsinda ya methyl na hydroxypropyl kugirango ikore hydroxypropyl methylcellulose.
Isuku: Ibisubizo byibyakozwe na reagent bisigaye bivanwaho gukaraba, kuyungurura no gukama kugirango ubone HPMC nziza.
Mugenzura uko ibintu byifashe (nkubushyuhe, igihe, igipimo cya reagent, nibindi), urwego rwo gusimbuza nuburemere bwa molekuline ya HPMC irashobora guhinduka kugirango ibone ibicuruzwa bifite ibintu bitandukanye.
3. Imirima yo gusaba ya HPMC
Ibikoresho byo kubaka
Mu nganda zubaka, HPMC ikoreshwa cyane muri sima ya sima, ibicuruzwa bya gypsumu, ibifuniko, nibindi. Ibikorwa byayo byingenzi birimo:
Kubyimba no kubika amazi: Muri minisiteri no gutwikira, HPMC irashobora kongera ubukonje no kunoza imikorere yubwubatsi, mugihe itanga ingaruka nziza yo gufata amazi no gukumira kugabanuka.
Kunoza gufatira hamwe: Gushimangira guhuza hagati ya minisiteri na substrate no kuzamura ubwubatsi.
Kunoza imitungo yubwubatsi: Gukora ubwubatsi bwa minisiteri no gutwikira byoroshye, kwagura igihe cyo gufungura no kunoza ubuso bwubutaka.
Inganda zimiti
Ikoreshwa rya HPMC mu nganda zimiti rigaragarira cyane cyane mu gutegura imiti, cyane cyane ibinini byo mu kanwa na capsules:
Ibikoresho byo kurekura bigenzurwa: HPMC ikoreshwa mugutegura ibinini bisohoka bigenzurwa, kandi kurekura buhoro ibiyobyabwenge bigerwaho muguhindura igipimo cyo gusesa.
Guhuza ibinini bya tableti: Mubikorwa bya tablet, HPMC irashobora gukoreshwa nkumuhuza kugirango utange ibinini bikwiranye nigihe cyo gusenyuka.
Gufata amafirime: bikoreshwa nkibikoresho byo gutwikira ibinini kugirango wirinde okiside nubushuhe bw’ibiyobyabwenge no kunoza ibiyobyabwenge no kugaragara.
Inganda zikora ibiribwa
HPMC ikoreshwa nk'inyongera y'ibiribwa mu nganda y'ibiribwa, ikina uruhare rwo kubyimba, emulisiferi, stabilisateur, nibindi.:
Thickener: ikoreshwa mubikomoka ku mata, isosi, nibindi kugirango itange uburyohe nuburyohe.
Emulsifier: mubinyobwa na ice cream, ifasha gukora sisitemu ihamye.
Filime yambere: muri bombo na keke, HPMC ikoreshwa mugutwikira no kumurika kugirango tunoze isura nuburyo bwibiryo.
Amavuta yo kwisiga
Mu kwisiga, HPMC ikoreshwa mugutegura emulisiyo, amavuta, geles, nibindi.:
Kubyimba no gutuza: mu kwisiga, HPMC itanga ubukonje bukwiye kandi butajegajega, itezimbere imiterere no gukwirakwira.
Kuvomera: birashobora gukora urwego rutanga uruhu hejuru yuruhu kugirango byongere ingaruka yibicuruzwa.
Imiti ya buri munsi
HPMC ikoreshwa kandi mubicuruzwa bya chimique bya buri munsi, nkibikoresho byoza, ibicuruzwa byita kumuntu, nibindi.:
Thickener: mumashanyarazi, byongera ubwiza bwibicuruzwa kugirango birinde ibice.
Guhagarika ibikorwa: bikoreshwa muri sisitemu yo guhagarika kugirango itange ihagarikwa ryiza.
4. Inyungu n'ibibazo bya HPMC
Ibyiza
Guhinduranya: HPMC ifite imirimo myinshi kandi irashobora gukina imirimo itandukanye mubice bitandukanye, nko kubyimba, gufata amazi, gutuza, nibindi.
Biocompatibilité: Uburozi buke hamwe na biocompatibilité nziza bituma bukoreshwa mubiribwa nubuvuzi.
Ibidukikije byangiza ibidukikije: bikomoka kuri selile karemano, ibinyabuzima byangiza kandi bitangiza ibidukikije.
Inzitizi
Igiciro: Ugereranije nibikoresho bimwe na bimwe bya polymer yubukorikori, HPMC ifite igiciro cyinshi, gishobora kugabanya ikoreshwa ryayo mubikorwa bimwe.
Igikorwa cyo kubyaza umusaruro: Igikorwa cyo kwitegura gikubiyemo imiti igoye hamwe nintambwe yo kweza, bigomba kugenzurwa cyane kugirango ibicuruzwa bibe byiza.
5. Ibizaza
Hamwe niterambere ryubumenyi nikoranabuhanga, ibyifuzo bya HPMC ni binini cyane. Icyerekezo cy'ubushakashatsi kizaza kirimo:
Iterambere rya HPMC ryahinduwe: Binyuze mu guhindura imiti hamwe nikoranabuhanga rikomatanya, ibikomoka kuri HPMC bifite imirimo yihariye byateguwe kugirango byuzuze ibisabwa byihariye.
Gahunda yo gutegura icyatsi: Ubushakashatsi burenze ibidukikije kandi bunoze bwo gutegura kugirango ugabanye ibiciro byumusaruro nuburemere bwibidukikije.
Ahantu hashya hasabwa: Shakisha ikoreshwa rya HPMC mubice bigenda bigaragara, nka biomaterial, gupakira kwangirika, nibindi.
Nkibikomoka kuri selile byingenzi, hydroxypropyl methylcellulose (HPMC) ifite ibintu byiza byumubiri nubumara, ahantu hatandukanye hakoreshwa kandi biocompatibilité. Mu iterambere ry'ejo hazaza, binyuze mu guhanga udushya mu ikoranabuhanga no kwagura porogaramu, HPMC iteganijwe gukina ibyiza byayo mu nzego nyinshi kandi igatanga imbaraga nshya mu iterambere ry'inganda.
Igihe cyo kohereza: Jun-25-2024