Hydroxypropyl selulose (HPC) ni polymer itandukanye ikoreshwa cyane muburyo bwo kuvura imiti, cyane cyane muburyo bukomeye bwa dosiye nka tableti na capsules.Imiterere yihariye ya fiziki-chimique ituma iba ikintu cyiza cyane muburyo bwo gutanga ibiyobyabwenge.
1. Guhuza ibinini
Hydroxypropyl selulose ningirakamaro muguhindura ibinini, biteza imbere guhuza ifu ivanze mugihe cyo kumeza.Nka binder, HPC:
Itezimbere imbaraga za mashini: Yongera uburinganire bwububiko bwibinini, bigabanya amahirwe yo gukata, guturika, cyangwa kumeneka mugihe cyo gutwara no gutwara.
Yorohereza Granulation: Muri granulation itose, HPC ikora nkibikoresho bifasha mugukora granules zifite ubunini nuburemere bukomeye, butanga uburemere bwibinini hamwe nibiyobyabwenge bihoraho.
2. Filime Yahoze
HPC ikoreshwa cyane nkumukozi ukora firime muburyo bwo gutwikira, aho itanga ibyiza byinshi:
Isohora rigenzurwa: Filime ya HPC irashobora guhindura irekurwa ryibikoresho bikora bya farumasi (API) biva kuri tablet, bigatuma bikwiranye-kurekura no kwagura-gusohora.
Inzitizi yo gukingira: Igice cya firime cyakozwe na HPC kirashobora kurinda intandaro ya tablet ibintu bidukikije nkubushuhe, urumuri, na ogisijeni, bityo bikazamura umutekano wibiyobyabwenge.
3. Kugenzura Matrix
HPC ifite uruhare runini mugutegura matrike irekurwa:
Ibyiza byo kubyimba: HPC irabyimba iyo ihuye na gastrointestinal fluid, ikora matrix imeze nka gel igenzura igipimo cyo kurekura ibiyobyabwenge.Iyi myitwarire yo kubyimba ningirakamaro mugukomeza umwirondoro uhoraho mugihe kinini.
Guhinduka: Kurekura ibintu biranga matrike ya HPC birashobora guhuzwa muguhindura polymer yibanze, uburemere bwa molekile, hamwe nurwego rwo gusimburwa, bitanga guhinduka mugushushanya imyirondoro yabigenewe.
4. Kongera imbaraga zo gukemura
HPC irashobora kongera imbaraga hamwe na bioavailable yimiti idashonga mumazi hakoreshejwe uburyo nka:
Ikwirakwizwa rikomeye: HPC irashobora gukoreshwa mugutandukanya ibintu bikomeye aho imiti ikwirakwizwa kurwego rwa molekile muri materix ya polymer, bikongerera imbaraga.
Leta ya Amorphous Stabilisation: Irashobora guhagarika uburyo bwa amorphous yibiyobyabwenge, mubisanzwe bigira imbaraga nyinshi ugereranije na kristu zabo.
5. Kunoza imikorere
HPC igira uruhare mugutunganya neza mubikorwa bya tablet:
Ibyiza bitemba: Itezimbere uruvange rwifu yifu, igabanya ibibazo bijyanye no gutembera kwifu ya poro mugihe cyo kwikuramo ibinini.
Amavuta: Nubwo atari amavuta yambere, HPC irashobora gufasha mukugabanya ubushyamirane hagati yurubaho no gupfa, byoroha gusohora ibinini byoroshye.
6. Ibyiza bya Mucoadhesive
HPC yerekana ibintu bya mucoadhesive bishobora kuba byiza muri sisitemu zimwe na zimwe zo gutanga ibiyobyabwenge:
Kuzigama Kuzigama: Muri tableti ya buccal cyangwa sublingual, HPC irashobora kongera igihe cyo gutura kumpapuro za dosiye aho zinjirira, biganisha ku gufata neza imiti no gukora neza.
7. Umutekano na Biocompatibilité
HPC ibangikanye kandi mubisanzwe ifatwa nkumutekano (GRAS) ninzego zibishinzwe, bigatuma ikoreshwa muburyo butandukanye bwo gukoresha imiti.Umwirondoro wacyo wumutekano wemerera gukoreshwa mubantu batandukanye barwayi, harimo ubuvuzi bwabana naba geriatrics.
8. Gufata neza no gukora
HPC irashobora kandi gukoreshwa muburyo bwiza bwububiko bwibinini:
Kuryoha uburyohe: HPC irashobora guhisha uburyohe budasanzwe bwibiyobyabwenge, bikarushaho kubahiriza abarwayi.
Ibara no Kumenyekanisha: Itanga ubuso bworoshye bushobora kuba amabara byoroshye cyangwa gucapwa kugirango ibicuruzwa bimenyekane kandi bitandukanye.
9. Kongera imbaraga
Hydroxypropyl selulose irashobora kongera ituze ryibikoresho bya farumasi ikora:
Kwirinda Gutesha agaciro: Inzitizi zayo zo gukingira zirashobora gukumira iyangirika rya API zoroshye kubirinda ibidukikije.
Ubwuzuzanye: HPC irahujwe nubwoko butandukanye bwa APIs nibindi bicuruzwa, bigabanya ibyago byimikoranire mibi ishobora kugira ingaruka kumikorere no kumikorere ya dosiye.
10. Guhindagurika muburyo butandukanye
HPC ihindagurika irenze ibinini bisanzwe:
Capsules: Mubisobanuro bya capsule, HPC irashobora gukora nkuguhuza no gusenya, guteza imbere ikwirakwizwa rimwe ryibiyobyabwenge no gutuma isenyuka ryihuse rimaze kuribwa.
Filime zo mu kanwa na Filime Ntoya: HPC irashobora gukoreshwa mugutegura firime zo mu kanwa na firime zoroheje zo gutanga imiti vuba vuba, ifitiye akamaro abarwayi bafite ikibazo cyo kumira ibinini cyangwa capsules.
11. Kuborohereza gukoreshwa mubikorwa
Hydroxypropyl selulose iroroshye kubyitwaramo no kuyinjiza mubikorwa byo gukora:
Gukemura: Irashobora gukemuka haba mumazi no mumashanyarazi kama, bigatuma habaho guhinduka mugutezimbere no gutezimbere.
Ubushyuhe bwa Thermal: HPC yerekana neza ubushyuhe bwumuriro, bukaba bwiza mugihe cyibikorwa birimo ubushyuhe, nko gutwika firime no gukama.
12. Ikiguzi-Cyiza
HPC irasa nigiciro cyinshi ugereranije na polymers kabuhariwe, itanga uburinganire hagati yimikorere nubushobozi buke.Ubwinshi bwimikorere irashobora kugabanya ibikenerwa byinshi, byoroshya iterambere ryimikorere ninganda.
Inyigo hamwe na Porogaramu
Ubushakashatsi bwinshi bwakozwe bwerekana imikorere ya HPC muburyo butandukanye:
Kurekura Kurekura Kurekura: HPC yakoreshejwe neza muburyo bwa metformin hydrochloride ikomeza-kurekura, itanga imiti ihoraho mumasaha 12-24.
Kongera imbaraga za Solubility: Ibiyobyabwenge nka itraconazole byagaragaje uburyo bwiza bwo gukemura no bioavailability iyo byakozwe na HPC mukwirakwiza gukomeye.
Gufata amafirime: Mu bisate bisizwe na enteric, hifashishijwe HPC yakoreshejwe mu gutinza ibiyobyabwenge kugeza igihe ibinini bigeze mu mara, birinda ibiyobyabwenge aside aside.
Hydroxypropyl selulose itanga inyungu nyinshi nkibisanzwe muburyo bukomeye bwa dosiye.Inshingano zayo nka binder, firime yahoze, igenzurwa na matrix yo gusohora, hamwe no kongera imbaraga, hamwe nizindi, bishimangira imikorere yayo ningirakamaro mubikorwa bya farumasi.HPC yongerera imbaraga imashini, itajegajega, hamwe na bioavailable yibiyobyabwenge, kandi itanga uburyo bworoshye mugushiraho uburyo butandukanye bwo gutanga ibiyobyabwenge.Kuborohereza gukoreshwa, guhuza ibinyabuzima, no gukoresha neza ibiciro bigira uruhare runini mugutezimbere imiti igezweho.
Igihe cyo kohereza: Jun-19-2024