Hydroxypropyl methyl selulose (HPMC) ni ibintu byinshi kandi bikoreshwa cyane bitari ionic selulose ether, bikunze gukoreshwa mubikorwa bitandukanye kubera imiterere yihariye yabyo. Ibipimo byingenzi bya tekiniki ya HPMC birashobora gushyirwa mubice byimiterere yumubiri, imiti, nibikorwa, buri kimwe kigira uruhare muburyo bukoreshwa mubikorwa byihariye.
1. Ibyiza byumubiri
a. Kugaragara
HPMC muri rusange ni ifu yera-yera yera, idafite impumuro nziza kandi itaryoshye, byerekana ubuziranenge bwayo kandi ikwiriye gukoreshwa mubikorwa byoroshye nka farumasi nibiryo.
b. Ingano ya Particle
Ingano yubunini bwa HPMC irashobora kugira ingaruka ku gukemuka kwayo no gukwirakwizwa mumazi cyangwa andi mashanyarazi. Ubusanzwe iraboneka mubyiciro bitandukanye, aho ingano yubunini igabanywa kuva neza kugeza ifu yuzuye. Ingano nziza cyane iganisha ku gipimo cyihuta.
c. Ubucucike bwinshi
Ubwinshi bwinshi ni ikimenyetso cyingenzi, cyane cyane kubikorwa no gutunganya. Ubusanzwe iri hagati ya 0,25 na 0,70 g / cm³, bigira ingaruka kumiterere yibikoresho nibisabwa.
d. Ibirimwo
Ubushuhe buri muri HPMC bugomba kuba buto kugirango habeho ituze no kwirinda guhunika mugihe cyo kubika. Ubushuhe busanzwe buri munsi ya 5%, akenshi hafi 2-3%.
2. Ibiranga imiti
a. Methoxy na Hydroxypropyl Ibirimo
Urwego rwo gusimbuza imikorere (–OCH₃) na hydroxypropyl (–OCH₂CH₂OH) ni ibipimo byerekana imiti, bigira ingaruka ku gukomera, ubushyuhe bwa gelation, hamwe nubukonje bwa HPMC. Ibisanzwe bisanzwe bigizwe na 19-30%, hamwe na hydroxypropyl kuva kuri 4-12%.
b. Viscosity
Viscosity nimwe mubintu byingenzi, bisobanura imikorere ya HPMC mubisabwa. Ipimirwa mubisubizo byamazi, mubisanzwe ukoresheje viscometer. Viscosity irashobora kuva kuri centipoise nkeya (cP) kugeza hejuru ya 100.000 cP. Iyi ntera yagutse yemerera kwihindura mubikorwa bitandukanye byinganda.
c. pH Agaciro
PH yumuti wa 2% HPMC mubisanzwe igwa hagati ya 5.0 na 8.0. Ukutabogama ningirakamaro kugirango bihuze mubisobanuro, cyane cyane muri farumasi n'ibicuruzwa.
d. Isuku hamwe n’umwanda
Isuku ryinshi ningirakamaro, cyane cyane kubiribwa na farumasi. Umwanda nkibyuma biremereye (urugero, kurongora, arsenic) bigomba kuba bike. Ibisobanuro akenshi bisaba ibyuma biremereye kuba munsi ya 20 ppm.
3. Ibintu bikora
a. Gukemura
HPMC irashonga mumazi akonje kandi ashyushye, ikora ibisubizo bisobanutse cyangwa bituje, ibisubizo byijimye. Uku gukemura kabiri ni ingirakamaro kubintu bitandukanye, byemerera guhinduka mugihe cyo gutunganya.
b. Ubushyuhe bwa Thermal
Umutungo udasanzwe wa HPMC nubushobozi bwawo bwo gukora geles iyo ushyushye. Ubushyuhe bwa gelation buterwa nurwego rwo gusimbuza no kwibanda. Ubushyuhe busanzwe bwa gelation buri hagati ya 50 ° C kugeza 90 ° C. Uyu mutungo ukoreshwa mubisabwa nko kugenzura-kurekura imiti muri farumasi.
c. Ubushobozi bwo Gukora Filime
HPMC irashobora gukora firime zikomeye, zoroshye, kandi zibonerana. Uyu mutungo ukoreshwa cyane mubitambaro, kubika imiti, no gufunga ibiryo.
d. Igikorwa cyo hejuru
HPMC yerekana imiterere-yimikorere, itanga emulisifike ningaruka zo guhagarara. Ibi ni ingirakamaro cyane cyane mu kwisiga, imiti, ninganda zibiribwa aho hakenewe emulisiyo zihamye.
e. Kubika Amazi
Imwe mu miterere iranga HPMC nubushobozi bwayo bwo gufata amazi. Ifite akamaro kanini mukugumana ubuhehere, nibyingenzi mubikorwa nka minisiteri, plaster, na cosmetike.
4. Porogaramu zihariye nibisabwa
a. Imiti
Mu nganda zimiti, HPMC ikoreshwa nka binder, firime-yahoze, kandi igenzurwa-isohora. Ibipimo bya tekiniki nk'isuku ryinshi, amanota yihariye ya viscosity, hamwe ninzego zasimbuwe neza ni ngombwa kugirango habeho umutekano n'umutekano muri sisitemu yo gutanga ibiyobyabwenge.
b. Ubwubatsi
Mu bwubatsi, cyane cyane muri sima ishingiye kuri sima na gypsumu, HPMC ikoreshwa mugutezimbere imikorere, gufata amazi, no gufatira hamwe. Hano, viscosity, ingano yingingo, hamwe nuburyo bwo gufata amazi nibyingenzi.
c. Inganda zikora ibiribwa
HPMC ikoreshwa nkibibyimbye, emulisiferi, na stabilisateur mubicuruzwa bitandukanye byibiribwa. Kubikoresha ibiryo, ibipimo byinyungu birimo ubuziranenge bwinshi, kutagira uburozi, hamwe numwirondoro wihariye wijimye kugirango habeho imiterere ihamye kandi ihamye.
d. Kwita ku muntu no kwisiga
Mu bicuruzwa byita ku muntu ku giti cye, HPMC ihabwa agaciro kubera kubyimbye, kwigana, no gukora firime. Ibipimo byingenzi birimo gukemuka, kwiyegeranya, no kweza, kwemeza guhuza nibindi bintu hamwe nibicuruzwa byanyuma.
5. Kugenzura ubuziranenge nuburyo bwo gupima
Kugenzura ubuziranenge bwa HPMC bikubiyemo igeragezwa rikomeye ryimiterere yumubiri na chimique. Uburyo bukoreshwa mubizamini bukoreshwa harimo:
a. Igipimo cya Viscosity
Gukoresha viscometer zizunguruka kugirango umenye ubwiza bwibisubizo bya HPMC.
b. Isesengura
Uburyo nka NMR spectroscopy bukoreshwa mukumenya imikorere ya hydroxypropyl.
c. Kugena Ibirungo
Karl Fischer titre cyangwa igihombo kuburyo bwo kumisha (LOD) burakoreshwa.
d. Ingano yubunini
Gukwirakwiza Laser hamwe nuburyo bwo gushungura kugirango umenye ingano yikwirakwizwa.
e. pH Igipimo
Imetero ya pH ikoreshwa mugupima pH ibisubizo bya HPMC kugirango barebe ko byagenwe.
f. Kwipimisha Ibyuma Biremereye
Isesengura rya Atomic spekitroscopi (AAS) cyangwa isesengura rya plasma (ICP) rifatika kugirango hamenyekane umwanda w'icyuma.
Hydroxypropyl methyl selulose (HPMC) ninyongera yibikorwa byinshi hamwe nurwego runini rwa porogaramu, bisaba gusobanukirwa birambuye kubipimo bya tekiniki. Ibintu bifatika nkibigaragara, ingano yubunini, ubwinshi bwubwinshi, hamwe nubushuhe butanga uburyo bwiza bwo gutunganya no gutunganya. Ibikoresho bya chimique birimo vitamine na hydroxypropyl yibirimo, viscosity, pH, nubuziranenge byerekana ibikwiranye nibisabwa byihariye. Imiterere yimikorere nko gukemuka, ubushyuhe bwumuriro, ubushobozi bwo gukora firime, ibikorwa byubutaka, hamwe no gufata amazi birashimangira byinshi muburyo bwinshi. Mu gukurikiza ingamba zikomeye zo kugenzura ubuziranenge, HPMC irashobora gukoreshwa neza mu nganda zinyuranye, ikuzuza inshingano zitandukanye zikorwa kuva muri farumasi kugeza mubwubatsi.
Igihe cyo kohereza: Gicurasi-22-2024