Kunonosora igipimo cya HPMC muburyo bwa tablet ni inzira igoye ikubiyemo gusobanukirwa imiterere yumubiri nubumara bya HPMC nuburyo bwo kugera kubikorwa byifuzwa muguhindura formulaire.
Hitamo icyerekezo gikwiye cya HPMC: HPMC ifite ibisobanuro bitandukanye byubwiza. HPMC ifite ibishishwa bitandukanye bizagira ingaruka kubintu bikomeye no gukora firime yibiranga. Ubukonje buke HPMC ifasha kongera ibintu bikomeye, ariko birashobora gukenera guhuzwa nandi manota ya HPMC kugirango yungukire kumiterere yabo itandukanye.
Koresha uruvange rwibintu byinshi bya HPMC: Muri formulaire nziza, HPMCs nyinshi zisobanurwa mubisanzwe zikoreshwa icyarimwe kugirango zikoreshe byimazeyo ibintu bitandukanye byumubiri. Uku guhuza kunoza uburyo bwo gutwikira no gukora neza.
Ongeraho plasitike: Plastiseri nka polyethylene glycol (PEG), citrate ya triethyl, nibindi birashobora kunoza imiterere ya firime no kugabanya ubushyuhe bwikirahure (Tg), bityo bikazamura imiterere yumubiri.
Reba kwibanda ku gisubizo cyibisubizo: Ibikomeye bikemurwa byigisubizo bigira ingaruka zikomeye kumikorere. Gutwikira amazi hamwe nibintu bikomeye birashobora kugabanya igihe cyo gutwikira no kunoza umusaruro. Kurugero, mugihe ukoresheje Kollicoat® IR ishingiye kubikoresho, ibishishwa bya coating bishobora kuba hejuru ya 30%.
Hindura ibipimo byerekana uburyo bwo gutwikira: Ibipimo byo gutwikira, nk'igipimo cya spray, ubushyuhe bwo mu kirere bwinjira, ubushyuhe bw'inkono, umuvuduko wa atome, n'umuvuduko w'inkono, bizagira ingaruka ku bwiza no guhuza. Muguhindura ibipimo, ibisubizo byiza byo gutwikira birashobora kugerwaho.
Gukoresha uburemere buke buke bwa HPMC: Uburemere bushya bwa molekuline HPMC (nka hypromellose 2906, VLV hypromellose) irashobora kunoza uburyo bwo gutwikira ibinini no kugabanya ibiciro. Muguhuza hamwe na HPMC isanzwe, imitungo iringaniye irashobora kuboneka muburyo bwo kwinjiza ibicuruzwa byinshi, ntakibazo gifatika mugihe cyoroshye cyo gutwikira, hamwe na firime ya tablet ikomeye.
Reba ituze ryibikoresho bitwikiriye: HPMCP ni polymer ihamye cyane itajegajega ikomeza kubaho mugihe cy'ubushyuhe bwinshi, ibyo bikaba ari ngombwa kugirango harebwe ubuziranenge bwibinini bisize mugihe cyo kubika.
Hindura uburyo bwo gutegura igisubizo cyo gutwikira: Mugihe cyo gutegura neza imiti ivanze, gahoro gahoro ongeramo ifu ya HPMCP kumivange ivanze kugirango wirinde kwibumbira hamwe. Ibindi bikoresho mubisubizo bya coating nka plasitike, pigment na talc nabyo bigomba kongerwaho nkuko bikenewe.
Reba imiterere yibiyobyabwenge: Gukomera no gukomera kwibiyobyabwenge bizagira ingaruka kumahitamo yimiti. Kurugero, kubiyobyabwenge bifotora, opacifiers irashobora gukenerwa kugirango urinde ibiyobyabwenge kwangirika.
Kora isuzuma rya vitro hamwe nubushakashatsi butajegajega: Binyuze mu igeragezwa rya vitro yo gusenya no kwiga gutuza, imikorere yibinini bisizwe irashobora gusuzumwa kugirango hamenyekane neza imikorere ihamye yo gushira mubikorwa bifatika.
Iyo usuzumye neza ibintu byavuzwe haruguru hanyuma ugahindura ukurikije imiterere yihariye yumusaruro nibiranga ibiyobyabwenge, igipimo cya formula ya HPMC mugutwikiriye ibinini gishobora gutezimbere kugirango bigerweho neza, bihuje kandi bihamye.
Igihe cyo kohereza: Ukwakira-29-2024