Ether ya selile ni icyiciro cya polymer zahinduwe zishingiye kuri selile, zikoreshwa cyane munganda zimiti kubera imiterere myiza yumubiri nubumara. Ubwoko bwibanze bukubiyemo hydroxypropyl methylcellulose (HPMC), carboxymethyl selulose (CMC) na methyl selulose (MC). Ethers ya selulose ifite uburyo bwinshi bwo gukoresha muri farumasi, ikubiyemo ibinini, capsules, imyiteguro irekura-irekura hamwe n’amazi meza.
1. Gushyira mubinini na capsules
Mu myiteguro ya tablet na capsule, ethers ya selile ikoreshwa kenshi nka binders, disintegrants hamwe nibikoresho byo gutwikira. Nka binders, zirashobora kongera guhuza hagati yibiyobyabwenge, kuburyo ibinini bikora imiterere ihamye hamwe nubukomere bukwiye nigihe cyo gusenyuka. Ether ya selile irashobora kandi kunoza umuvuduko no kugabanuka kwibiyobyabwenge kandi bigatera imbere.
Binders: Kurugero, HPMC nkumuhuza irashobora gukwirakwizwa neza hejuru yibice byibiyobyabwenge, bigatanga gufatana hamwe kugirango ibinini bigumane imiterere ihamye mugihe cyo kwikuramo.
Disintegrants: Iyo ethers ya selile yabyimbye mumazi, irashobora kongera neza igipimo cyo gusenyuka kw'ibinini kandi bigatuma ibiyobyabwenge bisohoka vuba. MC na CMC, nkibidahwitse, birashobora kwihutisha isenyuka ryibinini mu nzira yigifu kandi bigateza imbere bioavailable yibiyobyabwenge binyuze muri hydrophilique no kubyimba.
Ibikoresho byo gutwikira: Ethers ya selile nka HPMC nayo ikoreshwa muburyo bwo gutwikira ibinini na capsules. Igipfundikizo ntigishobora guhisha gusa uburyohe bubi bwibiyobyabwenge, ariko kandi gitanga urwego rwo gukingira kugabanya ingaruka ziterwa nubushuhe bwibidukikije ku ihungabana ry’ibiyobyabwenge.
2. Gusaba mubikorwa byateguwe-kurekura
Ether ya selile ifite uruhare runini mugutegura-kurekura kandi bikoreshwa cyane mukugenzura igipimo cyibiyobyabwenge. Muguhindura ubwoko, ububobere hamwe nubushuhe bwa selile ya selile, abafarumasiye barashobora gukora imirongo itandukanye yo kurekura ibiyobyabwenge kugirango bagere ku gutinda gutinda, kurekurwa kugenzurwa cyangwa kurekurwa.
Igenzura rirekura: Ether ya selile nka HPMC na EC (Ethyl selulose) ikoreshwa nkibikoresho byo kurekura bigenzurwa mubisate bikomeza-kurekura. Barashobora gushonga buhoro buhoro mumubiri kugirango bagire urwego rwa gel, bityo bagenzure igipimo cyo kurekura imiti kandi bagumane plasma yibiyobyabwenge.
Ibikoresho bya Skeleton: Mu myiteguro ya skeleton ihoraho-irekura, ethers ya selile ikwirakwiza imiti muri matrix ikora urwego rwumuyoboro kugirango ihindure igipimo cy’imiti. Kurugero, ibikoresho bya skeleton ya HPMC bikora geles iyo bihuye namazi, bikabuza gusesekara vuba ibiyobyabwenge no kugera kubigenzura igihe kirekire.
3. Gushyira mubikorwa byamazi
Ether ya selile ikoreshwa cyane nkibyimbye, guhagarika imiti na stabilisateur mugutegura amazi. Zishobora kongera ubukonje n’ubudahangarwa bwimyiteguro y’amazi kandi bikabuza imiti gutuza cyangwa gutondeka mugihe cyo kubika.
Thickeners: Ethers ya selile (nka CMC) nkibibyimbye birashobora kongera ubukana bwimyiteguro y’amazi, ikemeza ko ibiyobyabwenge bikwirakwizwa kimwe, kandi bikumira imvura.
Ibikoresho byo guhagarika: HPMC na MC bikoreshwa nkibikoresho byo guhagarika imyiteguro y’amazi kugirango barebe ko ibice byahagaritswe bigabanywa neza mugihe cyateguwe hifashishijwe uburyo buhamye bwo gukumira ibiyobyabwenge.
Stabilisateur: Ethers ya selile irashobora kandi gukoreshwa nka stabilisateur kugirango iteze imbere imiti n’umubiri byimyiteguro y’amazi mugihe cyo kubika no kongera ubuzima bwibiyobyabwenge.
4. Ibindi bikorwa
Byongeye kandi, ether ya selile ikoreshwa no mugutegura transdermal no gutegura amaso yubuvuzi bwa farumasi. Bakora nk'abakora amafilime hamwe niyongera rya viscosity muri izi porogaramu kugirango barusheho guhuza no bioavailable yimyiteguro.
Imyiteguro ya Transdermal: HPMC na CMC bakunze gukoreshwa nkibikorwa bya firime muguhindura transdermal, biteza imbere kwinjiza ibiyobyabwenge mugihe hagenzurwa ihinduka ryamazi nigipimo cyibiyobyabwenge.
Imyiteguro y'amaso: Mu myiteguro y'amaso, ether ya selulose ikoreshwa nk'ibibyimbye kugira ngo hongerwe imbaraga mu gufata imiti y'amaso, kongera igihe cyo gutura ibiyobyabwenge ku buso bwa ocular, no kunoza ingaruka zo kuvura.
Ikoreshwa ryinshi rya selile ya selile munganda zimiti ituruka kumiterere myiza yumubiri nubumara, nka biocompatibilité nziza, igenzurwa na solubile kandi ihindagurika kugirango ihuze ibyifuzo byimyiteguro itandukanye. Muguhitamo neza no gutezimbere ethers ya selile, uruganda rukora imiti rushobora kuzamura ireme n’umutekano w’imyiteguro y’ibiyobyabwenge kandi bigahuza abarwayi bakeneye umutekano w’ibiyobyabwenge kandi neza. Hamwe nogukomeza gutera imbere kwikoranabuhanga rya farumasi, ibyifuzo byo gukoresha selile ya selile bizaba binini.
Igihe cyo kohereza: Nyakanga-12-2024