Gushyira mu bikorwa Ethillyl Cellulose mu myiteguro ya farumasi

Ethylcellse (EC)ni igice cya kabiri cya polymer polymer cyabonetse nimyuka yibimera bisanzwe. Imiterere isanzwe ya molecular igizwe nibice bya glucose bihujwe na β-1,4-glycosic. Bitewe na biofore nziza, bidafite uburozi, igenzura ryiza kandi amasoko menshi, Ethyl selile irakoreshwa cyane mu myiteguro ya farumasi, cyane cyane mubikorwa bya faruceti.

1. Imiterere y'ibanze ya Ethyl selile

Ethyl selile ifite biocompaget kandi irashobora kubaho mumubiri wumuntu mugihe kirekire adakora ibintu byuburozi. Imiterere ya fotoimique iha hydrophobity nziza, gushikama, acide na aside na alkali hamwe nibikorwa bimwe na bimwe bigenzurwa. Byongeye kandi, Ethyl selile irashonga mumazi, ariko gushonga mubibazo bya kama nka Ethanol, Chloroform, HACETone, nibindi.

2. Gushyira mu bikorwa Ethyl selile mu myiteguro ya farumasi

Umwanya usaba Enescll selile ni menshi cyane, utwikiriye imyiteguro yo mu kanwa, inshinge, imyiteguro yo hanze nibindi byinshi. Ibikurikira nibyinshi byingenzi bya selile selile muri farumasi.

2.1 Kugenzurwa-Kurekura Imyiteguro yimiti yo mu kanwa

Ibyiciro rusange bya selile ya Ethyl ni nkumukozi ushinzwe kurekurwa, cyane cyane mumyiteguro yagenzuwe kubiyobyabwenge. Kamere ya Hydrophobic no kugenzura Ethyl selile ituma bigira ibiyobyabwenge byiza bikomeza kurekura ibikoresho. Mubiyobyabwenge byakomeje kwitegura, Ethyl selile irashobora gutinza igipimo cyo kurekura ibiyobyabwenge mugukora ishyaka rya firime, bityo bigera ku ntego yo kwikura ku biyobyabwenge. Muguhindura uburemere bwa molekili ya ettyl selile, ubunini bwikirenga hamwe nuburyo bwatoranijwe hamwe nuburyo bwo kurekura nuburyo bwo kurekura bushobora kugenzurwa.

Ethyl selile ikunze gukoreshwa mugutegura ibinini byagutse byo mu kanwa. Ibiyobyabwenge byiziritse muri firime ya selile ya Ethyl. Inzira yo kurekura ibiyobyabwenge irashobora kugenzurwa no kubyimba no kukengurwa na firime no kwinjira muri socieve. Ukurikije imiterere itandukanye hamwe nuburyo butandukanye, Ethyl selile irashobora kugenzura neza igihe cyibiyobyabwenge, kugabanya umubare wibihe, kandi utezimbere kubahiriza.

2.2 Filime y'ibiyobyabwenge

Mubiteganijwe ibiyobyabwenge, Ethyl selile irasanzwe ikoreshwa mugukunda film, cyane cyane mumateguro akomeye nka tableti, granules na capsules. Nkibintu byo gusiga filime, Ethyl selile ifite imitungo myiza ya firime, uburyo bwiza nububasha, ishobora gutanga ibiyobyabwenge byangiritse cyangwa birinda inzira ya gastrointestinal mubidukikije. Muri icyo gihe, filime ya selile ya Ethyl irashobora kugenzura igipimo cyo kurekura ibiyobyabwenge, cyane cyane mu guhindura filkness z'ubunini no gukoresha imyumvire itandukanye, imirongo itandukanye irashobora kugerwaho.

Nkibikoresho byo gupfukirana, Ethyl selile irashobora kandi kuzamura uburyohe bwibiyobyabwenge, irinde gusharira cyangwa kutamererwa neza, no kongera umuntu kwibasirwa.

2.3 Emalion na misellar

Bitewe no kwikebagura no gukora hejuru, Ethyl selile ikoreshwa nayo cyane mumagana no kwitegura Microcli. Mugutegura amapfa, Ethyl selile, nka Emulsifier na Stabilizer, birashobora kunoza neza ibiyobyabwenge no kurangiza gukora ibiyobyabwenge. Cyane cyane kubiyobyabwenge, Ethyl selile irashobora gufasha kugirango bidashira ibiyobyabwenge mu cyiciro giteganijwe, kugabanya imvura yibiyobyabwenge mumazi, kandi binoza ibinyabuzima bikabije.

Mu myiteguro ya Misellar, Ethyl selile, nk'intagondwa, irashobora gukora imiterere ya miriyoni ihamye y'ibiyobyabwenge, bityo ikandagira ibibazo n'ibinyabuzima byo mu mubiri, cyane cyane ku biyobyabwenge.

2.4 Imyiteguro y'ibiyobyabwenge

KimaCell®Icyubahiro nicyo gikoreshwa cyane mugutegura ibiyobyabwenge, cyane cyane mugutegura amavuta, amavuta, gels hamwe nizindi myiteguro. Nkumupfakazi, firime yahoze ari Stabilizer, Ethyl selile irashobora kunoza uburyo bwo gukwirakwiza, gukomera no guhuriza hamwe nibiyobyabwenge. Mu myiteguro yibanze nko amavuta na cream, Ethyl selile irashobora kunoza visosite no gutuza imyiteguro, ibone isabukuru imwe kandi igabura gusohora ibiyobyabwenge mugihe cyo gukoresha.

Sisitemu y'ibiyobyabwenge 2.5

Ethyl selile irashobora kandi gukoreshwa nkumutwara ibiyobyabwenge, cyane cyane mugutegura nanocariers na microcarrier. Ethyl selile irashobora gukora ibintu bigoye hamwe na molekile y'ibiyobyabwenge kugirango itange neza ibiyobyabwenge. Muri sisitemu ya Nanocarrier, imiterere yubutaka ya selile selile irashobora kwiyongera kubintu byo guhindura imiti cyangwa kuvura kumubiri kugirango unoze uburyo bwo gupakira ibiyobyabwenge no kurekura ibicuruzwa.

3. Ibyiza nibibazo bya Ethyl selile

Nkumutwe wo gutegura ibiyobyabwenge, Kimacell®i helleulose ifite ibyiza byinshi. Ifite biocompatbility nziza na biodedaditality, bishobora kugabanya ingaruka mbi kumubiri wumuntu; Irashobora kugenga neza irekurwa ryibiyobyabwenge no kunoza ingaruka zimiti; Byongeye kandi, Ikoranabuhanga ryo gutunganya Ethyl Celllose rikuze, rikoreshwa cyane, ikiguzi gito, kandi kibereye umusaruro munini. Ariko, Ethyl selile kandi ahura nibibazo bimwe. Kurugero, munsi yindangagaciro zikabije cyangwa ubushyuhe bwinshi, ituze rya Ethyl selile irashobora kugabanuka, zishobora kugira ingaruka kubikorwa byagenwe mubidukikije byihariye.

Ethyl selileIfite amanota menshi yo gusaba mu myiteguro ya farumasi, cyane cyane mu mirima yo kwitegura igenzurwa, aho bireba film, amapfa, n'imyiteguro y'ibanze. Imitsi yacyo nziza yumubiri na shimi ituma byingenzi byingenzi mu myiteguro ya farumasi. Ariko, mubikorwa bifatika, biracyakenewe kugirango utezimbere kandi kunoza ubwoko bwihariye bwibiyobyabwenge hamwe nuburyo bwo kwitegura kugirango utsinde ibibazo byayo muburyo bwo gutuza, kurekura, no kurushaho kunoza ingaruka zimiti no kubahiriza ibiyobyabwenge.