Hydroxypropyl methylcellulose (hpmc)ndi mankhwala osokoneza bongo omwe amagwiritsidwa ntchito kwambiri mu mankhwala ogulitsa, chakudya, mafakitale omanga. Kapangidwe kake kamakhala ndi ma hydroxypyl ndi magulu a methyl, ndipo ntchito zake zazikulu zimakhala ngati thiccener, wobalalitsa, ndi zina mwazina.
1. Tanthauzo la HPMC ndi HPMCS
Kusiyanitsa kwakukulu pakati pa HPMC ndi HPMCS ndikuti "s" ya "S" yoimira gulu la "Sulfate"
HPMC: Ili ndi ydroxypropyl methylcellulose, yomwe ilibe magulu a sulfaate. Zimagwiritsidwa ntchito kawirikawiri mu chakudya, mankhwala, zodzola zodzola, zomangamanga ndi minda ina, ndipo zimakhala ndi zinthu zofunika monga kukula, mawonekedwe a filimu, ndi kubala. HPMC ndi kuphatikiza kwa hydroxypyl ndi magulu a methyl, ndi maonedwe ake, soluglity ndi rheoglity imatha kulamulidwa ndi kusintha madigirii osiyana.
HPMCS: HPMCS ndi hydroxypropyl methylcellulose Sulfate yokhala ndi magulu a sulfate. The "s" imayimira njira yofuula, yomwe nthawi zambiri imapangitsa kuti mankhwalawa agwiritse ntchito mankhwala a hydrophilic, komanso kukhazikika ndi kuwoneka mu njirayo kungakhale kosiyana. HPMCS nthawi zambiri imagwiritsidwa ntchito pamavuto omwe amafuna kukhazikika kwambiri komanso mankhwala apadera, monga gawo la pharmaceutical.
2. Kusiyana kwa mankhwala
Kapangidwe ka mankhwala kwa HPMC kumakhazikika pa cellulose, komwe kumasinthidwa ndi methylation ndi hydroxypropropropropropropropropy. Kapangidwe kake kamakhala ndi kusungunuka kwamadzi kwambiri ndipo kumatha kupanga yankho la colloidal m'madzi.
Kapangidwe ka mankhwala kwa HPMCS kumakhazikitsidwa pa hpmc ndikukhazikitsa magulu a sulfate, zomwe zimasintha hydrophilicity ndi magwiridwe antchito m'madzi ena osungunuka. Kukhazikitsa kwamagulu a sulfate kumathandizira kuwonjezera ma hydration ndipo kungakhudze kuchuluka kwake kapena kusokoneza mphamvu zake m'mikhalidwe ina.
3. Kusiyana kwa magwiridwe antchito
Kusungunuka: hpmc nthawi zambiri zimasungunuka m'madzi kuti mupange njira yothetsera ma viscous ndipo imasintha bwino. Kusungunuka kwake kosungunuka kumatha kusinthidwa ngati pakufunika, monga kuwongolera ubale wake ndi madzi ndi zopangika zanyengo zomwe zimawonetsedwa m'matumbi osiyanasiyana.
Kukhazikika: HPMCS yachulukitsa hydrophilicity chifukwa makonzedwe a magulu a sulfate, omwe amatha kukhazikika bwino m'magulu ena ogulitsa kapena zodzikongoletsera. Kuphatikiza apo, magulu a sulfate amathanso kupanga Kimacepmcs yokhazikika m'mikhalidwe ina, monga chinyezi chambiri kapena kusintha kwa pH komwe kumatha kuwonetsa kulolerana mwamphamvu.
Kugwirizana: Monga momwe zimagwiritsira ntchito mankhwala ophatikizika, hpmc kwatsimikiziridwa kwathunthu chifukwa cha chitetezo chake komanso chitetezo mu gawo la pharmaceutical. Komabe, chifukwa chowonjezera magulu a sulfate, hpmccs angafunikire maphunziro owonjezera osokoneza bongo pamapulogalamu ena.
4. Zolemba
HPMC: Kugwiritsa ntchito mankhwala osokoneza bongo (monga mankhwala omasulidwa, ovala mapiritsi), zodzoladzola, zodzoladzola, zomangamanga, chakudya ndi mafakitale ena. Zosasamala, hypoallergenicity ndi hicocammaturitity okwera zimapangitsa kuti ikhale yodziwika bwino, ka fibini yoyambirira ndi okhazikika m'mafakitale a mankhwala ndi chakudya.
HPMCS: Chifukwa cha zinthu zake zapadera zamankhwala komanso mawonekedwe ake osungirako, hpmcs amagwiritsidwa ntchito kwambiri pofuna kugwiritsa ntchito mankhwala opangira mankhwala, makamaka kukonza mankhwala omasulidwa. HPMCS nthawi zambiri imagwiritsidwa ntchito mu mankhwala osokoneza bongo komanso njira zingapo zoperekera mankhwala, ndipo nthawi zina zimagwiritsidwa ntchito pazowonjezera zakudya.
5.
HPMC ndi HPMCS ili ndi mitundu yosiyanasiyana yazogulitsa, yomwe nthawi zambiri imawerengedwa malinga ndi magawo monga kulemera kwa ma celecular, digiri ya chikondwerero, ndi kusungunuka. Zogulitsa zosiyanasiyana zimawonetsa magwiridwe osiyanasiyana pamapulogalamu osiyanasiyana.
HPMC ili ndi madigiri osiyanasiyana othamangitsidwa, ma visa osiyanasiyana ndi kusungunuka, ndipo ndi yoyenera m'minda yosiyanasiyana. Zolemba wamba zimaphatikizapo mafayilo otsika, mafayilo apakatikati, mamasukidwe apamwamba, etc.
Kuzindikira kwa HPMCS kumagawika malinga ndi gawo monga kuchuluka kwa chisungunuke, kusungunuka ndi hydrophilicity. HPMCCS yosiyanasiyana imatha kusinthidwa malinga ndi zofunikira zosiyanasiyana zamankhwala.
HPMC ndi HPMCS imakhala ndi kusiyana kwakukulu pamankhwala, magwiridwe antchito ndi madera ogwiritsira ntchito. HPMC ndi mdera la hydroxypypyl methylcelulose, yomwe imagwiritsidwa ntchito kwambiri m'minda yambiri; Ngakhale HPMCS ndi kahelipmcmc®hpmmc, yomwe ili ndi hydrophilicity ndi magwiridwe antchito, ndipo imagwiritsidwa ntchito makamaka pamakina omwe amafuna kukhazikika kwambiri, monga kumasulidwa kwa mankhwala.
Mukugwiritsa ntchito kwenikweni, kusankha kwaHpmckapena HPMCS iyenera kutsimikiza malinga ndi zosowa ndi mapulogalamu enieni. Ngati pali zofunikira zapadera zosungunuka, kukhazikika, etc., HPMCS ingayambike patsogolo. Ngati palibe zofunikira kwambiri pazowononga komanso magwiridwe antchito, hpmc ndi chisankho chofala komanso chachuma.
Post Nthawi: Jan-27-2025