Makhalidwe a Visccroxypropyl a Methylcellulose (HPMC) Fulu

Hydroxypropyl methylcellulose (hpmc)amagwiritsa ntchito polymer osungunulira kwambiri ndi ntchito zosiyanasiyana, makamaka pa mankhwala, chakudya, ndi zinthu zodzikongoletsera. Kutha kwake kupanga mayankho owoneka bwino, gel ofanana ndi gel osakanikirana ndi madzi kumapangitsa kuti ikhale yopanga bwino. Mawonekedwe a Kimacell®hpmc Mayankho amapeza gawo lofunikira posankha momwe amagwirira ntchito mosiyanasiyana. Kuzindikira mawonekedwe a ma viscckics a HPMC Aquaous mayankho ndikofunikira kuti muthe kugwiritsa ntchito mafakitale osiyanasiyana.

1. Kuyamba kwa Hydroxypropyl Methylcellulose (HPMC)

Hydroxypropyl methylcellulose ndi matenda opaka mafuta a semi. Imapangidwa ndi zolowa m'malo mwa ma cellulose ndi magulu a hydroxypyl ndi magulu a methyl. Chiwerengero chazolowazo zimatha kukhala zosiyanasiyana, zomwe zimapangitsa kuti magawo azigawo osiyanasiyana a hpmc okhala ndi mawonekedwe, kuphatikiza mamasukidwe. Kapangidwe ka HPMC kumakhala ndi msana wa cellulose ndi hydroxypropyl ndi methyl magulu omwe amaphatikizidwa ndi mayunitsi a glucose.

HPMC imagwiritsidwa ntchito mu mafakitale osiyanasiyana chifukwa cha kudzipha kwake, kuthekera kopanga ma gels, komanso kuchepetsa kusungunuka m'madzi. M'matumba am'madzi, hpmc amakhala ngati osafunikira, osungunuka-madzi omwe amathandizira kuti kwambiri njira yothetsera vutoli, makamaka mamasukidwe.

2. Makhalidwe a VisccCon of HPMC

Makulidwe a masinthidwe a HPMC amakhudzidwa ndi zinthu zingapo, kuphatikizapo kuchuluka kwa HPMC, kulemera kwa kuchuluka kwa polymer, kutentha, ndi zina zosungunulira. Pansipa pali zinthu zofunika kwambiri zomwe zimayang'anira mawonekedwe a ma viccor a HPMC m'mayankho am'madzi:

Kukhazikika kwa hpmc: Makulidwe amawonjezeka pamene kuchuluka kwa HPMC kumawonjezeka. Pokhala molekyu yapamwamba, mamolekyulu a HPMC amalumikizana kwambiri wina ndi mnzake, zomwe zimapangitsa kuti anthu ambiri asamaduke.

Ma molecular kulemera kwa hpmc: Makulidwe a masinthidwe a HPMC amakonzedwa mwamphamvu ndi kuchuluka kwa kuchuluka kwa polymer. Ma grade apamwamba kwambiri a HPMC amakonda kutulutsa ma virus ambiri. Izi ndichifukwa choti mamolekyulu akuluakulu a polymer amapanga kukana kwakukulu kuti ayende chifukwa chodzaza ndi kukangana kwawo.

Kutentha: Mauku amachepetsa ngati kutentha kumawonjezeka. Izi ndichifukwa choti kutentha kwambiri kumachepetsa mphamvu ya magulu azolowera pakati pa mamolekyu a HPMC, motero amachepetsa kuthekera kwawo.

Mtengo wometa: Makulidwe a HPMC mayankho a HPMC ndikumeta ubweya, makamaka m'madzi osakhala a Newtonian, omwe ndi njira zothetsera polymer. Pamitengo yotsika ya Shear, HPMC mayankho a HPMC imawonetsa mafayilo akuluakulu, pomwe ali pamlingo wambiri wa Shear, maulendowo amachepetsa chifukwa cha kugwedeza.

Mphamvu ya Ionic Mphamvu: Kukhalapo kwa ma electrolyte (monga mchere) mu yankho kumatha kusintha mafayilo. Mchere wina umatha kuwunika mphamvu zapakatikati pakati pa maunyolo a polymer, zomwe zimapangitsa kuti zichepetse bwino komanso zomwe zimapangitsa kuchepa kwa mafakisi.

3. Ma IscCence vs. ndende: Zoyeserera

Njira yodziwika bwino yoyesera ndikuti mamasukidwe a HPMC Aquous amawonjezeka kwambiri ndi polymer ndende. Ubale pakati pa ma visction ndi ndende imatha kufotokozedwa ndi equation yotsatirayi, yomwe nthawi zambiri imagwiritsidwa ntchito pothekera kwa polymer:

η = ACN \ ETA = AC ^ N Chanter = Acn

Kuti:

\ \ eta isc

CCC ndiye ndende ya HPMC

AAA ndi NNn ndi oyang'anira ambiri omwe amatengera mtundu wa HPMC ndi zochitika za yankho.

Pazinthu zochepa, ubalewo umakhala wozungulira, koma pakukula kwake kumawonjezeka, kuwunika kuwonekeratu, kuwonetsa kuchuluka kwa maunyolo pakati pa polymer pakati pauniins.

4. Ma IscCence vs. Kulemera kwa ma celecular

Kulemera kwa kaheacell®h®hpmmm kumachita mbali yofunika kwambiri mu mawonekedwe ake. Ma polecular olemera a HPMC amakonda kusintha ma virus ambiri a viscous m'malo otsika kwambiri poyerekeza ndi ma selecular olemera. Maonekedwe a mayankho opangidwa kuchokera ku HPMC-kulemera kwa HPMC imatha kukhala yolamula zingapo za kukula kuposa mayankho omwe amapangidwa kuchokera ku or-molecula-kulemera kwa HPMC.

Mwachitsanzo, yankho la HPMC yokhala ndi kulemera kwa ma 100,000 da awonetsera ma viccess apamwamba kuposa chimodzi ndi kulemera kwa 50,000 da pa ndende yomweyo.

5. Kutentha kwa mafayilo

Kutentha kumakhala ndi mphamvu kwambiri pakukweza kwa HPMC. Kuchuluka kwa kutentha kumabweretsa kuchepa kwa mawonekedwe a njirayi. Izi zimachitika makamaka chifukwa cha kuyenda kwamafuta a unyolo wa polymer, zomwe zimawapangitsa kusuntha momasuka, kuchepetsa kukana kwawo. Zotsatira za kutentha pa ufa nthawi zambiri zimayesedwa pogwiritsa ntchito equation yofanana:

η (t) = ηeeeart \ etta (t) = \ etta_0 e ^ {f {{f) {tt}} = ntchala

Kuti:

c (t) \ eta (t) cticy ndikuwoneka kutentha ttt

η0 \ eta_0 tsiku lililonse ndiye chinthu chowonjezera (mamasukidwe osamwa kwambiri)

Eae_aea ndiye mphamvu yoyendetsa

Rrr ndiye gasi nthawi zonse

TTT ndi kutentha kwathunthu

6. Khalidwe la Rheogical

Ntchentche yothetsera mayankho a HPMC imafotokozedwa kuti ndi yomwe si yatsopano, kutanthauza mafayilo osasinthika koma amasinthana ndi miseche. Pamitengo yotsika ya Shear, HPMC mayankho a HPMC ikuwonetsa mawonekedwe owoneka bwino chifukwa cha kukonzekera kwa maunyolo a polymer. Komabe, pamene kuchuluka kwake kumawonjezeka, ma vioncy amachepetsa - chodabwitsa chomwe chimadziwika kuti shear kuwonda.

Khalidwe loseketsa ili ndi njira zambiri za polymer, kuphatikiza hpmc. Kudalira kwa Shear Vuto la Masuvence kumatha kufotokozedwa pogwiritsa ntchito mtundu wamagetsi:

cteral (γ v γ v \ \ etta (\ dot {rot}) = k \ v

Kuti:

γ \ dot {\ gamma} γ γ γ

KKK ndi mndandanda wazosasinthika

Nnn ndiye cholowera cha mkhalidwe (wokhala ndi n <1n <1n <1) minda yochepa

7. Makutu a HPMC Mayankho: Gome Lalikulu

Pansipa pali tebulo mwachidule machitidwe a Victucs a HPMC Aquaous mayankho osiyanasiyana:

Machitidwe aHpmcMankhwala osintha amakhudzidwa ndi zinthu zingapo, kuphatikizapo ndende, kutukwana, kutentha, ndi mtengo wometa. HPMC ndi zinthu zolimba kwambiri, ndipo zinyengo zake zimakhala zopanda ntchito zomwe zimagwiritsidwa ntchito posintha magawo awa. Kuzindikira zinthuzi kumathandiza kuti ntchito yogwiritsa ntchito kimacelly®hpmc osiyanasiyana, kuchokera ku mankhwala osiyanasiyana, kuchokera ku chakudya ndi zodzoladzola. Pogwiritsa ntchito mikhalidwe yomwe HPMC imasungunuka, opanga amatha kukwaniritsa ma visction omwe akufuna kuti azifuna zosowa zawo.