Kusiyana kwa HPMC ndi MC

Hydroxypropyl methylcellulose (hpmc)ndiMethylcellulose (MC)Onse otumphuka amagwiritsidwa ntchito m'mafakitale osiyanasiyana, kuphatikizapo zamankhwala, zakudya, zodzola komanso zomangamanga. Ngakhale anali ofanana, zinthu ziwirizi zimakhala ndi mankhwala ndi ntchito zamankhwala.

1. Kapangidwe ka mankhwala

Onse a HPMC ndi MC ndi ma cellulose omwe amachokera ku cellulose, koma kusiyana kwakukulu ndi m'magulu a mankhwala omwe amaphatikizidwa ndi msana wakubwerera kwa cellulose.

Methylcellulose (MC): Izi zimapangidwa ndi methylation wa cellulose. Munjira iyi, magulu a methyl (-ch3) amaphatikizidwa ndi magulu a hydroxyl a mamolekyulu a cellulose. Ma digiri ya methylation nthawi zambiri amasiyanasiyana pakati pa 20-30%, kutengera kalasi ya MC, yomwe imakopa kusoka kwake ndi zina.

Hydroxypropyl methylcellulose (hpmc): Kimacell®hpmc ndi chinthu chovuta kwambiri. Kuphatikiza pa methylation, imachitikanso hydroxypylaty. Magulu a hydroxypyl (-ch2choch3) amadziwitsidwa kwa Moleluble Molekyu, limodzi ndi magulu a methyl. Mlingo wa hydroxypypypypypy ndi methylation digiri ya HPMC imatha kukhala yosiyanasiyana, yomwe imapereka magawo osiyanasiyana a HPMC yokhala ndi mikhalidwe yosiyanasiyana.

2. Kusalola

Solubility ndi imodzi mwazinthu zofunikira kwambiri poyerekeza MC ndi HPMC. Kusungunuka kwa ma cellulose awa kumadalira kuchuluka kwa malo olowa m'malo mwa nkhaniyo.

Methylcellulose (MC): MC imasungunuka m'madzi otentha koma amapanga gel pazizirira. Katundu wapaderawu wopanga ma gels akamatenthedwa ndikubwerera ku malo ozizira ndi amodzi mwa mikhalidwe yofunika kwambiri ya MC. Ndi zopanda madzi m'madzi ozizira, koma osungunuka m'madzi otentha pamwamba pa kutentha kwina (50-70 ° C), ndipo miyala yamfuzi imasintha.

Hydroxypropyl methylcellulose (hpmc): Hpmc, kumbali ina, amasungunuka m'madzi onse ozizira komanso otentha. Izi zimapangitsa kuti lizisinthana ndi MC. Kusungunuka kwa HPMC kumayendetsedwa ndi mtundu wa kuloweza (kuchuluka kwa methyl kupita ku magulu a hydroxypyl) ndi kalasi ya Masukini. Madigiri ambiri olowa m'malo mwake amasungunuka osungunuka m'madzi pamtenthedwe wotsika.

3. Kukweza

Makutu amatenga gawo labwino pakugwiritsa ntchito, makamaka m'mafakitale a mankhwala ndi chakudya.

Methylcellulose (MC): Mawonekedwe a Kimacell®mc ndi kutentha. Makutu amawonjezeka akamatenthedwa, ndipo imawonetsa chodabwitsa cha gelation. Kuchuluka kwa zolowa m'malo kumakhudzanso mafayilo, ndi magawo am'mwamba nthawi zambiri amakhala ndi mafayilo apamwamba.

Hydroxypropyl methylcellulose (hpmc): HPMC nthawi zambiri imakhala ndi mbiri ya Viccess yomwe ikuyerekezedwa ndi MC. Makulidwe a HPMC imathandizidwanso ndi kuchuluka kwa zolowa m'malo, koma zimakhalabe zokhazikika pamayendedwe ochulukirapo. Kuphatikiza apo, hpmc imatha kukhala ndi ma visa osiyanasiyana, kuchokera pansi mpaka kukwera, kutengera ntchito yomwe mukufuna.

4. Mapulogalamu

Onse a MC ndi HPMC amagwiritsidwa ntchito kwambiri mu mankhwala ogulitsa, chakudya, ndi mafakitale odzikongoletsa, koma zomwe aliyense amapanga kuti azigwiritsa ntchito bwino ntchito zina.

Methylcellulose (MC):

Mankhwala: MC nthawi zambiri imagwiritsidwa ntchito ngati binder, kusazindikira, ndi zolumikizira mu piritsi mu piritsi chifukwa cha kuchuluka kwake kwavilatu. Amagwiritsidwanso ntchito pomasulidwa.

Makampani Ogulitsa Chakudya: MC imagwiritsidwa ntchito ngati chakudya tricker, emulsifier, ndi kukhazikika. Katundu wopangidwa ndi gel osafunikira pakupanga zinthu ngati ayisikilimu, mavalidwe saladi, ndi zinthu zophika.

Choongoletsera: MC imagwiritsidwa ntchito modzola chifukwa cha kukula kwake, emulsifying, ndikukhazikika, komanso zolimbitsa thupi zopangidwa ngati mafuta odzola, shampoos, ndi mafuta.

Hydroxypropyl methylcellulose (hpmc):

Mankhwala: HPMC imagwiritsidwa ntchito kwambiri ngati balar ndi omasulidwa-omasulidwa mu ma piritsi. Amagwiritsidwanso ntchito mu ma ophthalmic mayankho monga mafuta opangira mankhwala osokoneza bongo.

Makampani Ogulitsa Chakudya: HPMC imagwiritsidwa ntchito kuphika kwa gluten yopanda gluten, chifukwa imatsata mawonekedwe ndi kutupa kwa gluten mu mtanda. Amagwiritsidwanso ntchito ngati wokhazikika komanso emulsifier muzakudya zopangidwa zosiyanasiyana.

Kumanga: HPMC imagwiritsidwa ntchito ngati zowonjezera mu simenti, pulasitala, ndi tims. Imathandiza kugwirira ntchito, kusungidwa kwamadzi, komanso kutsatira.

5. Katundu wina

Hygroscopicity: HPMC nthawi zambiri imakhala yowonjezera hygroscopic (yokopa madzi) kuposa MC, yomwe imapangitsa kuti ikhale yothandiza pogwiritsa ntchito pomwe chinyezi chosungira chimafunikira.

Kukhazikika kwa mafuta: MC imakonda kuwonetsa bwino matenthedwe chifukwa cha katundu wake. HPMC, pomwe mumakhazikika munjira yotentha, sizingapereke mphamvu zofananira monga MC.

6. Chidule cha Kusiyana

Pomwe onse awiriHpmcndiMCndi ma cellulose omwe ali ndi ntchito zopitilira muyeso, zopangidwa zawo zodziwika bwino ndi katundu zimapangitsa kuti akhale oyenera kuti azigwiritsa ntchito mosiyanasiyana. MC ndiofunika kwambiri pantchito yomwe imapindula ndi katundu wake, pomwe kukhazikika kwakukulitsa kwa HPMC kumapangitsa kuti azisinthana mafakitale, kuphatikizapo chakudya. Kumvetsetsa izi kumathandiza posankha zofunikira pazinthu zina.