Kuyesa kwa ma hydration kuchepetsa mikhalidwe ya hydroxypropyl methylcellulose hpmc

Hydroxypropyl methylcellulose (hpmc)ndi polymer yosungunuka yamadzi yomwe imagwiritsidwa ntchito kwambiri pomanga zida, mankhwala ndi zakudya ndi mafakisoni. HPMC ili ndi mphamvu yokulirapo, kusungidwa kwamadzi, kapangidwe ka mafilimu komanso kugwiritsa ntchito katundu, ndipo ndizofunikira kwambiri muzinthu zochokera kumenti ndi gypsum. Njira zosinthika za Kimacell®hpmc mu madzi zimakhudzidwa ndi zinthu zambiri, zomwe zimakhala zofunikira, makamaka mu matope omanga, zomaliza ndi zinthu zina. Chifukwa chake, kuphunzira kuchepetsedwa kwa HPMC ndikofunikira kwambiri kuti mutsanu bwino.

1. Hpmc hydration kuchepetsa njira

Kufalikira kwa HPMC m'madzi kumaphatikizapo magawo anayi: nthaka yonyowa, tinthu tating'onoting'ono timatupa, kutupa ndi kusungunuka. Pamene mdera likulumbiridwa ndi HPMC ikukhudzana mwachindunji ndi madzi, malo otsekera pamtunda amatenga madzi mwachangu, zomwe zimalepheretsa kusokonekera kwa tinthu tating'onoting'ono, posonyeza kuchedwetsa hydrate kuchedwa phenomenon. Pofuna kukonza magwiridwe antchito, zinthu zina za HPMC zimathandizidwa mwapadera, monga kuthandizidwa ndi thupi kapena kuwongolera, kuti muwonjezere nthawi yothandizira hydration ndikusintha nthawi yomanga.

Zinthu zazikulu zomwe zimakhudza kuchepa mphamvu kwa hydration zimaphatikizapo:

Tinthu kukula kwa tinthu: tinthu tating'onoting'ono timasungunuka pang'onopang'ono kuposa tinthu tating'onoting'ono, ndipo nthawi yocheza ndi hydration imachedwa.

Pamtunda: Ma HPMCS ena amalumikizidwa kapena hydrophobhofically yolumikizidwa, yomwe imatha kuchepetsedwa kwambiri hydration.

Mafuta othetsa Mayankho: Kutentha kwambiri kumatha kusintha kusungunuka kwa HPMC, koma kungakhudzenso mikhalidwe yochedwetsa hydration mkati mwa mtundu winawake.

Solvents System: Electrolytes, mtengo wa pH ndi zina zowonjezera zimatha kukhudza kugunda kwa chipongwe ndi hydration kuchepetsa nthawi ya HPMC.

2. Mapangidwe oyeserera ndi njira

2.1 zoyeserera zoyesera

Zitsanzo za HPMC (ma viscosties osiyanasiyana, mitundu yosiyanasiyana yazosangalatsa)

Madzi osungunuka

Chida Chosangalatsa

Woyendayenda (monga wozungulira)

Laser tinthu tambala

2.2 Njira yoyesera

Kutsimikiza kwa kuchepetsa hydration nthawi

Kutentha kosalekeza (25 ℃), kuchuluka kwa kaheanll®hpm kunali kuwaza madzi osasunthika, ndipo nthawi yofunikira kuti mawonekedwe a gel apangire komanso nthawi yomwe tinthu timene timanyozedwa kwathunthu.

Kusintha kwa Visccess

Masinthidwe akusintha mphindi 5 iliyonse pogwiritsa ntchito wotchire yosinthitsira kuti alembe zitsulo za HPMC tinthu tambiri.

Kuyesa kwa Solubili

Ma Sapling adachitidwa munthawi yosiyanasiyana, ndipo tinthu tating'onoting'ono tomwe timalekanitsidwa ndi nembanemba kuti mudziwe zomwe zimasungunuka pakapita nthawi.

Kusanthula kwa tinthu tating'onoting'ono

Tizilombo tating'onoting'ono tinthu tatifikir timagwiritsidwa ntchito pofufuza kusintha kwa tinthu tating'onoting'ono ti tinthu tating'onoting'ono tofana ndi tinthu tating'onoting'ono tomwe timatha kuwunika momwe ma hydration akuchedwa kuchedwa kwa hydration.

3. Zotsatira za mayeso ndi kusanthula

Zotsatira zoyeserera zikuwonetsa kuti HPMC yokhala ndi mafilimu osiyanasiyana komanso njira zochizira pamtunda zimakhala ndi mawonekedwe osiyanasiyana hydration. HPMC Popanda chithandizo cha pansi zimapanga pang'onopang'ono m'madzi, pomwe HPMC yokhala ndi chithandizo chapadera imakhala ndi nthawi yocheza kwambiri ndi nthawi yochepa kwambiri.

Mphamvu ya Makulidwe pa Kuchedwa Hydration

Tinthu tambiri ya HPMC imakhala ndi nthawi yochepa yochedwetsa hydrate chifukwa cha kulemera kwawo kwaching'ono; High-Viscked HPMC ili ndi nthawi yocheza ndi hydrate chifukwa cha mawonekedwe ake otalika.

Zotsatira za chithandizo chamankhwala chochedwa hydration

Tinthu ta hpmc timathandizidwa ndi ma hydrophobic chofunda zimachepetsa kunyowa m'madzi, ndipo nthawi yocheza ya hydration imatha kukulitsidwa mpaka mphindi 10-30.

Mphamvu ya Kugawa Kwa tinthu

Tinthu tating'onoting'ono timakhala ndi nthawi yochepa yocheza, pomwe tinthu tating'onoting'ono timakhala ndi kuchepa kwamphamvu kwa hydrate chifukwa cha mphamvu ya gel wosanjikiza.

Kusankha kusankha kwaHpmcMutha kukonza ntchito yake pantchito yomanga ndi mafakitale ena, sinthani magwiridwe antchito ndi kukhazikika kwa zinthu zakuthupi. Phunziroli limatha kupereka maziko a siyansi kuti agwiritse ntchito a HPMC ndikuwongolera chitukuko cha mankhwala ndi kusintha