Synthesis ndi mikhalidwe ya hydroxypypyl methylcellulose

Hydroxypropyl methylcellulose (hpmc)ndi cellulose yopanda ionic ether yopangidwa kuchokera ku cellulose yachilengedwe kudzera mu kusintha kwa mankhwala. Amagwiritsidwa ntchito kwambiri pankhani ya zomangamanga, mankhwala, chakudya ndi zodzola. Kuphatikizika kwake ndi mawonekedwe ake kumawapatsa magwiridwe apadera ndipo kumatha kukwaniritsa zofunikira zosiyanasiyana mafakitale.

1. Kaphatikizidwe wa hydroxypropyll methylcellulose

Kukonzekera kwa Kimacell®hpmc amagwiritsa ntchito cellulose zachilengedwe monga rawzinthu ndi kusinthasintha kudzera mu alkali ochiritsa ndi zowunikira. Njira yodziwika bwino imaphatikizanso njira zotsatirazi:

Alkization wa cellulose

Ma cellulose ophika (monga thonje zamkati kapena zamkati zamkati) zimasakanizidwa ndi sodium hydroxide Solution ndikusinthasintha pa kutentha ndi kupanikizika kwa alkali. Njira yolumikizira ikukulitsa ma cellulose molecular unyolo ndikuwonjezera kufupika kwake ndi wothandizila.

Kuzindikira

Ma cellulose cellose amachitika ndi formaldehyde ndi ma propylene glycol propylene oxide kuti apange hydroxypyulose. Panthawi ya methylation ndi hydroxypropropropropropropropyh

Kusintha ndi kutsuka

Pambuyo pa zomwe zimachitika, yankho la acidic limawonjezeredwa kuti lisasakanizo, kenako ndikutsukidwa ndi madzi kuti muchotse zida zosakwanira komanso zinthu kuti zipeze HPMC.

Kuyanika ndi kuphwanya

Wonyowa HPMC imauma kuti ikhale chinyezi chochepa ndikuphwanya ufa kuti mupeze chinthu chomaliza. Kukula kwa chinthu kumatha kusinthidwa mogwirizana ndi zofunikira kugwiritsa ntchito.

2. Makhalidwe ogulitsa a hydroxypropyll methylcellulose

HPMC ili ndi zinthu zapadera komanso zamankhwala, zomwe zimapangitsa kuti zikhale bwino pazosiyanasiyana:

Kusungunuka kwamadzi abwino

HPMC imatha kusungunuka mwachangu m'madzi ozizira kuti apange yankho la colloidal colloidal, ndipo kususuka kwake sikukhudzidwa ndi kuuma kwamadzi. HPMC imakhuthula m'madzi otentha, koma imatha kubwezeretsanso kusungunuka madzi atakhazikika. Katunduyu amapanga kukhala koyenera kwa zojambula zomwe zimafunikira matenthedwe a matenthedwe.

Zokhazikika

HPMC ndi chinthu chosakhala cha ionic polekerera kwa asidi, alkalis ndi mchere, ndipo imatha kukhazikika pansi pa mankhunje osiyanasiyana.

Zabwino kwambiri komanso zotsatsa

Madzi am'madzi a hpmc ali ndi mphamvu yayikulu, ndipo mafano ake amawonjezeka ndi kuchuluka kwa ndende komanso molemphuka. Kutsatsa kwake ndi mawonekedwe ake opanga mafilimu kumapangitsa kuti azichita bwino zofunda ndi zomatira.

Zabwino kwambiri za mafuta

Njira yothetsera HPMC imagwirizana ndi mitundu yotseguka pomwe imatentha ndikubwerera kumadzi mutazizira. Katundu wamtunduwu umagwiritsidwa ntchito kwambiri pomanga (monga matope a simenti) kuti apititse patsogolo ntchito zomanga.

Osakhala oledzeretsa ndi bioom

Popeza hpmc imachokera ku cellulose wachilengedwe ndipo ali ndi chitetezo chamtengo wapatali komanso chitetezo, imagwiritsidwa ntchito kwambiri pazowonjezera zowonjezera komanso zowonjezera matrix.

Kusinthasintha kusintha

Mlingo wa zolowa m'malo mwa Kimacell®hpmc imatha kusintha malinga ndi kufunikira kwake, potsatira kusintha kwake kusungunuka, mawonekedwe a milandu ndi zinthu zina zokwaniritsa zofunikira za mapulogalamu osiyanasiyana.

3. Kugwiritsa ntchito magawo ndi chiyembekezo

Hpmc Itha kugwiritsidwa ntchito ngati chivundi ndi kutsika kwamadzi mu gawo lomanga, monga mankhwala osokoneza bongo mu gawo la pharmaceutical, komanso ngati emulsifier ndi okhazikika m'makampani azakudya. Ndi kupititsa patsogolo kwamankhwala obiriwira komanso kukula kokhazikika, kaphatikizidwe kakang'ono ka HPMC kumangokhala kafukufuku wamtsogolo.

Hydroxypypyl wa methylcellulose yakhala chinthu chofunikira kwambiri komanso chofunikira pamoyo wamakono komanso moyo watsiku ndi tsiku ndi ntchito yake yayikulu komanso yothandiza.