1. Makhalidwe Ogulitsa
Kapangidwe ka mankhwala ndi kapangidwe kakeHydroxypropyl methylcellulose (hpmc)ndi mankhwala osokoneza bongo omwe amapezeka ndi kusintha kwa mankhwala. Amapangidwa kuchokera ku cellulose wachilengedwe kudzera mu ethylation, methylation ndi hydroxyproproproproproproproproproproproproprople. Mu kapangidwe kake, mafupa a cellulose amalumikizidwa ndi mayunitsi a β-D
Katundu wathupi
Kusungunuka: Kimacell®hpmc ndi yopanda madzi ndi okhazikika, koma imatha kupanga yankho la colloidal yozizira m'madzi ozizira. Kusungunuka kwake ndikofanana ndi zomwe zili hydroxypropyl ndi methyl mu molekyulu.
Ma Isccess: Njira yothetsera HPMC ili ndi ma vistoni ena, omwe nthawi zambiri amawonjezeka ndi kuchuluka kwa kuchuluka kwa ma celecular. Ma viscren amakulirakulira ndipo amatha kusinthidwa malinga ndi kufunikira kukwaniritsa zofunikira za minda yosiyanasiyana.
Kukhazikika kwa matenthedwe: hpmc kumakhala ndi bata kwambiri, kumatha kupirira kutentha kwambiri malo, ndipo sikophweka kuwola pakutentha.
Zogwirira Ntchito
Katundu wopanga makanema: hpmc ali ndi malo abwino opanga mafilimu ndipo amatha kupanga kanema wowonekera ndi yunifolomu mu njira yamadzi am'madzi, nthawi zambiri amagwiritsidwa ntchito ngati zinthu za matrix potulutsa mankhwala osokoneza bongo.
Emulsization ndi kukhazikika: Chifukwa cha ntchito yake, hpmc nthawi zambiri zimagwiritsidwa ntchito m'malo a emulsions, kuyimitsidwa, ma gels ndi mitundu ina kuti musinthe kukhazikika kwa mawonekedwe.
Kusungidwa kwamphamvu ndi madzi: HPMC ili ndi katundu wabwino kwambiri ndipo imatha kuwonjezera mafayilo a yankho kutsika kwambiri. Kuphatikiza apo, imatha kusunga madzi mozama, potero amawongolera kuchuluka kwa madzi osakhazikika, ndipo nthawi zambiri amapezeka mu zodzoladzola komanso mankhwala amtsiku ndi tsiku.
Zosagwirizana: Monga choperewera, hpmc chimatha kukhala chokhazikika mu asidi, alkali kapena mayankho amchere ndipo ali ndi kusintha kwamphamvu.
Madera Ogwiritsa Ntchito
Makampani ogulitsa mankhwala: monga wonyamula mankhwala, amazolowera kumasulidwa, kumasulidwa ndikukonzekera kumasulidwa; Amagwiritsidwanso ntchito pokonza mapiritsi, makapisozi ndi mafuta osokoneza bongo a mankhwala.
Makampani omanga: Monga zowonjezera, zimapangitsa magwiridwe antchito omanga monga matope ndi zofunda, ndipo amasintha motsatira mawu, madzi ndi kusungidwa kwamadzi.
Makampani ogulitsa zakudya: ntchito ngati thickener, emulsifier ndi gellierger yokomerera, mafuta odzola, ayisikilimu ndi zina.
Makampani opanga zodzikongoletsera: zogwiritsidwa ntchito mu zotupa, zozinga pakhungu, shampoos ndi zinthu zina zoperekera ma viccience komanso kukhazikika.
2. Njira ya Synthesis
Cellulose m'zigawo za hpmc kaye za HPMC yoyamba imafunikira kuchotsa ma cellulose ku zikondwerero zachilengedwe (monga nkhuni, thonje, etc.). Nthawi zambiri, zodetsa komanso zosakhala za cellulose monga vanine mu zinthu zopangira zimachotsedwa ndi njira zamakina. Kufuula kwa cellulose makamaka kumaphatikizapo kugwedezeka, alkali chithandizo chamankhwala, kuthilira komanso njira zina.
Kusintha kwa cellulose kwa cellulose yotulutsidwa komwe kumachitika kumachitika ndikuwonjezera m'malo a methyl ndi hydroxypropyl. Kutengera kwa makonda nthawi zambiri kumachitika mu alkaline wa alkaline, ndipo nthawi zambiri ogwiritsa ntchito a Hutheven Chloride (Ch3cl), Propy.
Methylation Kulanda: Cellulose imachitika ndi wothandizira wa methylang (monga methyl chloride) kuti magulu a hydroxyl amasinthidwa ndi magulu a methyl (-Och3).
Hydroxypypypy: Kuyambitsa hydroxypropyl (-c3hnioh magulu a celluule, omwe amagwiritsidwa ntchito kawirikawiri ndi ma progyle oxide. Mu izi, magulu ena a hydroxyl mu mamolekyulu a cellulose amasinthidwa ndi magulu a hydroxypyl.
Kuchita Kuwongolera Makhalidwe
Kutentha ndi nthawi: Njira yodziwitsa nthawi zambiri imachitika kutentha kwa 50-70 ° C, ndipo nthawi yocheza ndi pakati pa maola ochepa komanso maola opitilira khumi. Kutentha kwambiri kumatha kugwetsa ma cellulose, ndipo kutentha kwambiri kumabweretsa mphamvu zochepa.
Kuwongolera kwa PH Chuma: Zomwe zimachitika nthawi zambiri zimachitika mu mikhalidwe ya alkalinine, zomwe zimathandizira kukonza bwino momwe mukumvera.
Ansuretion Conterration: Kukhazikika kwa wothandizira kwa chinsinsi ali ndi mphamvu yofunikira pazinthu zomwe zimachitika. Kuyang'anira kwakukulu kumatha kuwonjezera kuchuluka kwa hydroxypropyl kapena methylation kwa chinthucho, potero kusintha magwiridwe antchito a Kimacell®hpmc.
Kuyeretsa ndi kuyanika pambuyo poti zitheke, malonda nthawi zambiri amafunika kutsukidwa ndi madzi kapena kuchotsedwa ndi zosungunulira kuchotsa zosungunulira zosafunikira komanso zopangidwa ndi zinthu. HPMC yoyeretsedwa imawuma kuti ipeze ufa kapena granular.
Kuchepetsa thupi pang'ono pa synthesis njira, maselo olemera a hpmc amatha kuwongoleredwa ndikusintha zochitika (monga kutentha, nthawi, komanso nthawi yovuta). HPMC yokhala ndi zolemera zosiyanasiyana kwa ma molecular zimasiyana mu kusungunuka, mafakisoni, kugwiritsa ntchito, etc., kulemera koyenera kumasankhidwa malinga ndi zosowa.
Monga zinthu zoopsa za polymer,Hpmcimagwiritsidwa ntchito kwambiri mu mankhwala, zomangamanga, chakudya ndi zodzola. Ubwino wake wabwino kwambiri, emulsization, kusungidwa kwamadzi komanso katundu wamafilimu amapangitsa kuti ikhale zinthu zofunika kwambiri za mafakitale. Njira ya hpmc ya HPMC imangotengera kutchuka kwa cellulose. Zomwe zimachitika (monga kutentha, pH yamtengo, kukwiya, etc.) ayenera kulamulidwa bwino kuti apeze zofunika pazinthu zomwe zimakwaniritsa zofunikira. M'tsogolomu, ntchito za HPMC zitha kukulitsidwanso m'minda yambiri.
Post Nthawi: Jan-27-2025