Hydroxypropyl methylcellulose (hpmc)ndi polymenical yosungunuka yosungunuka yamadzi yosiyanasiyana yomwe imagwiritsidwa ntchito mu minda yomanga, mankhwala, zodzoladzola, chakudya ndi mafuta a petroleamu. Zimachokera pazithunzi zachilengedwe cellulose ndipo imapezeka kudzera mu kusintha kwa mankhwala. Ili ndi madzi abwino osungunuka, kukulira, mawonekedwe a filimu ndi zotsatsa. Kupanga kwa mafakitale kwa Kimacell®hpmg makamaka kumaphatikizapo kusintha kwa cellulose. Zochita zodziwika bwino zimaphatikizapo methylation ndi hydroxypropropropropy.
1. Zida zopangira ndi zokonda za HPMC
Ma cellulose ophika: Kupanga kwa HPMC kumayamba ndi cellulose wachilengedwe. Magwero wamba amaphatikizapo ulusi wolima monga mtengo zamkati, thonje, ndi hemp. Pofuna kuonetsetsa kuti zinthu zikuchitika potsatira, cellulose nthawi zambiri zimafunikira kuyesedwa kuti zichotse zodetsa komanso kuwonjezera ntchito.
Njira Zodziyimira: Kukondanitsa kwa cellulose nthawi zambiri kumaphatikizapo zinthu monga kuchapa, kuyanika, ndi kuphwanya, ndikuphwanya ma cellulose kapena mapangidwe obwera chifukwa cha zomwe zimachitika.
2. Njira ya hpmc ya HPMC
Kaphatikizidwe ka HPMC makamaka kumaphatikizapo methylation ndi hydroxypypylation kumachitika, komwe kumachitika pansi pa milkingine mikhalidwe. Njira yopanga imaphatikizaponso njira zotsatirazi:
Kuyambitsa kwa Cellulose: Kuti mupange cellulose kukhala kosavuta kugwiritsidwa ntchito kwa mankhwala, nthawi zambiri kumafunikira njira yothetsera cyululose monga sodium hydroude (Naoh) kuti apeze matrix otupa. Pakadali pano, makwerero a cellulose amachepetsa ndipo kapangidwe kake kamakhala losir, komwe kumathandiza pakusintha kwamankhwala.
Methylation Kuyankha: Chiwonetsero cha methylation chimasintha molenulu ya cellulose poyambitsa gulu la methyl (-ch₃). Othandizira a methylaing omwe amagwiritsidwa ntchito ndi methyl chloride (ch₃cl) kapena chloroform (chll₃). Pamaso pa sodium hydroxide, wothandizira wa methylaing amachita ndi ma cellulose kuti asinthe magulu ena a hydroxyl (-Oh) pa ma celluluse molekyu ndi methyl (-ch₃), potengera methyl cellulose.
Hydroxypypypy Zomwe zimachitika zimachitika mu mikhalidwe ya alkaline. Matenda a hydroxypypypypy amalowa m'magulu ena a methoxy pa molekyulu ya cellulose omwe ali ndi magulu a hydroxypyl, potero amapanga HPMC.
Kuwongolera: Pa nthawi yonseyi, kutentha, nthawi ndi kuchuluka kwa kuchuluka kwa ma hydroxyplat ya kimacellyc kukwaniritsa zofunikira za malonda. Nthawi zambiri, kutentha kwamo kumayang'aniridwa pakati pa 30 ndi 80 ° C, ndi nthawi yochita kuchokera maola angapo mpaka maola khumi.
Kusalowerera ndi kuyeretsa: Pambuyo pa zomwe anachita zimakwaniritsidwa, chinthucho chimayenera kukhala chosayenera kukhala chosasinthika komanso chowonjezera acid, hydrochloric alkines alkalinine. Njira zoyeretsa zimaphatikizira kuchapa, kusema, kuwuma ndi njira zina kuti muchotse zinthu zosakwanira, ma sol sol osakhazikika komanso zopangidwa ndi zinthu.
3. Kuwuma kwamasamba ndi kunyamula
Kuyanika: Kuyeretsedwa kwa HPMC nthawi zambiri kumakhala mu mawonekedwe a ufa wosungunuka wamadzi, ndipo chinyezi chimayenera kuchotsedwa ndi kuyanika kwa utsi, kuwuma kwina ndi njira zina. Chouma chouma chimayenera kukhala ndi chinyezi chochepa, nthawi zambiri chimayendetsedwa pansi pa 5%, kuteteza malonda kuti asamamizire komanso akunyoza.
Kuyika: HPMC youma imayikidwa mu mawonekedwe a ufa, ndipo madandaulo amafunikira chithandizo chonyowa. Nthawi zambiri zimakonzedwa m'matumba a polyethylene, matumba a pepala kapena matumba ophatikizika kuti azingoyendera.
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Mu kupanga HPMC, kuwongolera koyenera ndikofunikira. Khalidwe la HPMC limangotengera mtundu wa zinthu zosaphika, komanso pazomwe zimachitika monga momwe zinthu zikugwirira ntchito. Opanga nthawi zambiri amakhala ndi mayendedwe abwino malinga ndi malamulo apadziko lonse komanso achigawo. Zizindikiro zodziwika bwino zimaphatikizapo:
Kusungunuka: HPMC iyenera kukhala ndi madzi osungunuka ndi madzi abwino komanso kusungunuka muyezo woyenera kukwaniritsa zofunikira zomwe zafotokozedwazo.
Ma Isccess: Makutu a HPMC amakhudza mwachindunji ntchito yake, ndipo zinthu zosiyanasiyana zimakhala ndi ma vincked. Njira zoyeserera zoyeserera za Isccec Grookfield Viscfict.
Zoyera ndi Zosayera: Kudetsa zinthu mu zinthu za HPMC kuyenera kulamulidwa mkati mwake kuti zitsimikizike kuti zitsimikizike kuti zikhale zoyera.
Kukula kwa tinthu: Kutengera zosowa zingapo zofunsira, kukula kwa tinthu ta hpmc kumatha kusiyanasiyana, ndipo zinthu zabwino kapena zopanga granlar zimakhala ndi zochitika zosiyanasiyana.
5. Ntchito zofunsira za HPMC
HPMC imagwiritsidwa ntchito kwambiri m'mafakitale ambiri ndipo ili ndi phindu lamalonda.
Makampani omanga: HPMC imagwiritsidwa ntchito kwambiri ngati yolimbitsa thupi ndi matope opanga matope, zofunkha zam'matamba ndi matayala, zomwe zimatha kusintha magwiridwe antchito ndi madzi osungira.
Makampani ogulitsa mankhwala: HPMC ili ndi mapulogalamu ofunikira mu gawo la pharmaceutical ya mankhwala monga zipolopolo, piritsi zomata komanso zonyamula mankhwala osokoneza bongo.
Makampani Ogulitsa Chakudya: Mu chakudya, hpmc imagwiritsidwa ntchito ngati thickener, hitebiliface, emulsifier, etc., yomwe imatha kukonza kapangidwe ndi kukoma kwa chakudya.
Makampani odzikongoletsa: hpmc amagwiritsidwa ntchito ngati chowonjezera komanso chopanga mafilimu muzodzola, ndipo chimagwiritsidwa ntchito popanga zinthu monga zotupa ndi mafuta.
Minda ina: Kimacell®hpmc imagwiritsidwanso ntchito kwambiri m'makampani monga petroleum, zolemba, pepala, ndi zokutira.
Kupanga mafakitale aHpmcZimasintha cellulose zachilengedwe kukhala polymer polymer yophatikizika ndi zinthu zingapo m'matumbo osiyanasiyana kusintha kwa mankhwala. Mwa kuwongolera zomwe zimachitika moyenera ndi njira zothandizira chithandizo, hpmc zomwe zimakwaniritsa zofunikira pakugwiritsa ntchito zitha kupezeka. Ndi ntchito yofala ya HPMC, kafukufuku wochulukirapo komanso kafukufuku wochulukirapo ndi ukadaulo angapitirize kulimbikitsa kusintha kwake kapangidwe kake ndi mtundu wazogulitsa.
Post Nthawi: Jan-27-2025