1. Chemical Structure nke HPMC:
HPMC bụ ọkara sịntetik, inert, polymer viscoelastic nke sitere na cellulose. Ọ mejupụtara nkeji ugboro ugboro nke molekul glucose jikọtara ọnụ, yana ogo dị iche iche nke nnọchi. Ndochi a gụnyere hydroxypropyl (-CH2CHOHCH3) na methoxy (-OCH3) otu jikọtara na nkeji anhydroglucose nke cellulose. Ngbanwe a na-enye HPMC akụrụngwa pụrụ iche, gụnyere solubility mmiri ya.
2. Ngwakọta hydrogen:
Otu n'ime isi ihe kpatara HPMC solubility n'ime mmiri bụ ikike ya ịmepụta njikọ hydrogen. Njikọ hydrogen na-apụta n'etiti otu hydroxyl (OH) nke HPMC na ụmụ irighiri mmiri. Otu hydroxyl dị na ụmụ irighiri ihe HPMC nwere ike imekọrịta ihe na ụmụ irighiri mmiri site na njikọta hydrogen, na-eme ka usoro mgbasa. Ndị agha intermolecular ndị a dị oké mkpa maka ịkụda ike ndị na-adọrọ adọrọ n'etiti ụmụ irighiri ihe HPMC ma mee ka ha gbasaa na mmiri.
3. Ọkwa nke nnọchi:
Ogo nke nnọchi (DS) na-ezo aka na nkezi ọnụọgụ hydroxypropyl na otu methoxy kwa otu anhydroglucose n'ime molekul HPMC. Ụkpụrụ DS dị elu n'ozuzu na-akwalite mmiri solubility nke HPMC. Nke a bụ n'ihi na ọnụ ọgụgụ na-abawanye ụba nke ihe nnọchi hydrophilic na-eme ka mmekọrịta polymer na ụmụ irighiri mmiri dị mma, na-akwalite mgbasa.
4. Arọ Molecular:
The molekụla arọ nke HPMC na-emetụta ya solubility. N'ozuzu, akara ule HPMC dị arọ dị ala na-egosipụta ịdị mma nke ọma na mmiri. Nke a bụ n'ihi na agbụ polymer pere mpe nwere saịtị ndị ọzọ enwere ike ịnweta maka mmekọrịta ya na ụmụ irighiri mmiri, na-eduga na mgbaze ngwa ngwa.
5. Àgwà Ọzịza:
HPMC nwere ike ịza nke ukwuu mgbe ekpughere ya na mmiri. Ọzịza a na-eme n'ihi ọdịdị hydrophilic nke polymer na ikike ọ nwere ịmịkọrọ ụmụ irighiri mmiri. Ka mmiri na-abanye n'ime matrix polymer, ọ na-akpaghasị ndị agha intermolecular n'etiti agbụ HPMC, na-eduga na nkewa ha na mgbasa na ihe mgbaze.
6. Usoro mgbasa ozi:
The solubility nke HPMC na mmiri na-enwe mmetụta ya dispersion usoro. Mgbe HPMC na-agbakwunyere na mmiri, ọ na-enweta usoro nke wetting, ebe mmiri molecule gbara gburugburu polymer ahụ. Mgbe nke ahụ gasịrị, irighiri ihe ndị polymer na-agbasa n'ime ihe mgbaze, na-enyere aka site na mkpasu iwe ma ọ bụ ngwakọta igwe. A na-akwado usoro mgbasa ozi site na njikọ hydrogen dị n'etiti HPMC na ụmụ irighiri mmiri.
7. Ionic ike na pH:
Ike ionic na pH nke ngwọta nwere ike imetụta solubility nke HPMC. HPMC na-agbaze karịa na mmiri nwere ike ionic dị ala yana pH na-anọpụ iche. Ngwọta ike ionic dị elu ma ọ bụ ọnọdụ pH dị oke egwu nwere ike igbochi njikọ hydrogen n'etiti HPMC na ụmụ irighiri mmiri, si otú a na-ebelata ike ya.
8. Okpomọkụ:
Okpomọkụ nwekwara ike imetụta solubility nke HPMC na mmiri. N'ozuzu, elu okpomọkụ na-eme ka mgbasa nke HPMC dịkwuo elu n'ihi ike na-abawanye ike, nke na-akwalite mmegharị molecular na mmekọrịta n'etiti polymer na mmiri mmiri.
9. itinye uche:
Ịta nke HPMC na ngwọta nwere ike imetụta ya solubility. N'ihe dị ntakịrị, HPMC na-agbaze ngwa ngwa na mmiri. Otú ọ dị, ka ntinye uche na-abawanye, ụdọ polymer nwere ike ịmalite ịchịkọta ma ọ bụ kechie ya, na-eduga n'ịbelata solubility.
10. Ọrụ na nhazi ọgwụ:
A na-eji HPMC n'ọtụtụ ebe na usoro ọgwụ dị ka polymer hydrophilic iji melite solubility ọgwụ, bioavailability, na ntọhapụ a na-achịkwa. Ọdịmma mmiri ya dị mma na-enye ohere maka nkwadebe nke ụdị usoro ọgwụgwọ kwụsiri ike ma dịkwa mfe agbasa dị ka mbadamba nkume, capsules, na nkwusioru.
solubility nke HPMC n'ime mmiri na-ekwu na ya pụrụ iche chemical Ọdịdị, nke na-agụnye hydrophilic hydroxypropyl na methoxy otu, ikwado hydrogen bonding na mmiri molekul. Ihe ndị ọzọ dị ka ogo nke nnọchi, ịdị arọ molekụla, omume ọzịza, usoro mgbasa ozi, ike ionic, pH, okpomọkụ, na itinye uche na-emetụtakwa njirimara solubility ya. Ịghọta ihe ndị a dị oke mkpa maka iji HPMC nke ọma na ngwa dị iche iche, gụnyere ọgwụ, nri, ihe ịchọ mma, na ụlọ ọrụ ndị ọzọ.
Oge nzipu: Mar-21-2024