Ọkwa ọgwụhydroxypropyl methylcellulose (HPMC)bụ ihe eji emepụta ọgwụ na-ejikarị eme ihe, nke a na-ejikarị eme ihe na ụlọ ọrụ ọgwụ n'ihi na ọ dị mma biocompatibility na nkwụsi ike.
1. Excipients na ọgwụ nkwadebe
A na-ejikarị HPMC eme ihe dị ka ihe mgbakwunye na nkwadebe ọgwụ, tumadi maka nkwadebe nke mbadamba nkume, capsules, granules, wdg. Ebe ọ bụ na HPMC nwere ezigbo adhesion, ojiji ya na mbadamba nkume nwere ike ịkwalite ike na nkwụsi ike nke mbadamba.
2. Onye ntọhapụ na-achịkwa
A na-eji HPMC eme ihe na nkwadebe ntọhapụ a na-achịkwa. Enwere ike gbanwee ọnụego mwepụta ọgwụ site n'ịgbanwe ịdị arọ molekụla na viscosity nke HPMC. Ngwongwo na-agbaze mmiri nke HPMC na-enyere ya aka ịmepụta gels na mmiri, si otú ahụ na-achịkwa ọnụego ntọhapụ nke ọgwụ ọjọọ na ịnweta ntọhapụ ọgwụ na-adịgide adịgide. Ihe onwunwe a dị mkpa karịsịa na ọgwụgwọ ọgwụ nke ọrịa na-adịghị ala ala dị ka ọrịa shuga na ọbara mgbali elu.
3. Thickers maka ngwọta na nkwusioru
HPMC, dị ka a thickener, nwere ike n'ụzọ dị irè dịkwuo viscosity nke ngwọta na suspensions na melite nkwụsi ike na operability nke ọgwụ. N'ime nkwadebe mmiri mmiri, iji HPMC nwere ike melite nkwusioru ọgwụ, zere mmiri ozuzo, ma hụ na otu ọgwụ.
4. Nkwadebe nke mpụga
A na-ejikwa HPMC n'ọtụtụ ebe na nkwadebe mpụga (dị ka ude, gels, patches, wdg). N'ihi ya ọma adhesion na moisturizing Njirimara, HPMC nwere ike welie spreadability na akpụkpọ permeability nke mpụga nkwadebe na melite obodo nrụpụta ọrụ nke ọgwụ ọjọọ. Na mgbakwunye, HPMC nwere ike inye ezigbo adhesion mgbe ị na-akwadebe patches ndu iji hụ na nrachi siri ike nke patches na akpụkpọ ahụ.
5. Nkwadebe anya
Na nkwadebe anya, a na-eji HPMC mee ihe dị ka akụkụ nke anya mmiri na-emepụta ihe na anya mmiri. Nnukwu viscosity ya na ihe na-edozi ahụ nwere ike belata anya nkụ nke ọma, nye mmanu na-adịgide adịgide, ma melite nkasi obi onye ọrịa.
6. Ndị na-ebu ọgwụ Nano
N'afọ ndị na-adịbeghị anya, a mụọlakwa HPMC dị ka onye na-ebu ọgwụ nano. Site na ijikọ na nanoparticles, HPMC nwere ike melite bioavailability nke ọgwụ ọjọọ, belata nsi, na nweta ọgwụ ezubere iche maka nnyefe. Nchọpụta a na-enye echiche ọhụrụ maka ọgwụgwọ ọrịa ndị na-adịghị agwụ agwụ dị ka ọrịa kansa.
7. Ihe eji eme biomedical
The biocompatibility nkeHPMCna-emekwa ka ọ baa uru n'ọhịa nke ihe ndị dị ndụ. Enwere ike iji ya kwadebe ihe nkiri biofilms, scaffolds, wdg, na-akwalite uto cell na mmeghari ohuru, a na-ejikwa ya na nkà mmụta anụ ahụ na nkà mmụta ọgwụ.
8. Ngwa ndị ọzọ
Na mgbakwunye na ojiji ndị a dị n'elu, a na-ejikwa HPMC na nri, ihe ịchọ mma na ubi ndị ọzọ dị ka ihe na-esikwu ike na stabilizer. Dịka ọmụmaatụ, na nri, HPMC nwere ike iji mee ka ọdịdị na uto nke nri dịkwuo mma; na ihe ịchọ mma, enwere ike iji ya dị ka onye na-agba ume na emulsifier iji meziwanye nkwụsi ike na mmetụta nke ngwaahịa ahụ.
Pharmaceutical ọkwa HPMC aghọwo ihe dị oké mkpa ihe na ọgwụ na biomedical ubi n'ihi ya versatility na magburu onwe biocompatibility. Site na mmepe nke sayensị na teknụzụ, ngwa ngwa na teknụzụ HPMC ga-aga n'ihu na-abawanye, na-enye nkwado maka mmepe nke nkwadebe ọgwụ ọhụrụ na ụzọ ọgwụgwọ. N'ọdịnihu, nyocha na HPMC ga-adịkwu omimi, na-atọ ntọala maka ngwa ya n'ọtụtụ ebe.
Oge nzipu: Nov-07-2024