Ihe omuma viscosit nke Hydropyl Methylcellose (HPMC)

Hydroxypylththththththylcelllose (hpmc)bụ polymer mmiri na-ejikarị ngwa dị iche iche, ọkachasị na ọgwụ, nri, na ngwaahịa ịchọ mma. Ikike ya na-etolite nnukwu ihe, na-edozi ahụ mgbe agwakọta na mmiri na-eme ka ọ bụrụ ihe dị iche. Nleta visacell®hpmc ngwọta dị mkpa na-ekpebi arụmọrụ ha na nhazi dị iche iche. Ghọta njirimara viscositse nke Ngwọta HPMC A Ngwọta Dị Mkpa Iji Na-emepụta Ihe Ha Na-arụ n'Ime Otu.

1. Okwu Mmalite na Hydropyythylthylthyllllose (HPMC)

Hydroxypyl Methylcellose bụ ọkara synhethy delivative nke cellose. A na-emepụta ya site na nhichapụ nke cellose na hydroxyyl dị iche iche na otu methy. Onu ogugu ndi a nwere ike idi iche, na - eduga na akara mmụta dịgasị iche nke HPMC na njiri mara, gụnyere viscosis. Ọdịdị nke HPMC mejupụtara ihe ballose ballone na hydroxypyl na methy na methyl jikọtara ọnụ na ngalaba gluco.

A na-eji HPMC rụọ ọrụ n'ọtụtụ ụlọ ọrụ n'ihi biocombilitibity ya, ike iji ụdị osisi, na ịdị jụụ nke solkality. Na ngwọta osisi, Hpmc na-akpa àgwà dị ka nke na-abụghị nke a na-abụghị ionic, mmiri na-eme nke ọma na-emetụta ihe ngwọta nke ihe ngwọta ahụ, karịsịa viscosity.

2. Njirimara viscosit nke Ngwọta HPMC

Ngwọta viscity HPMC na-emetụta ọtụtụ ihe, gụnyere ịta HPMC, oke molecular nke polymer, okpomọkụ na ọnụnọ nke nnu ma ọ bụ ụda ndị ọzọ. N'okpuru ebe a bụ isi ihe ndị na-achịkwa njirimara viscosics nke HPMC na menu nke ọma:

Ista nke hpmc: Viscosity na-abawanye ka ịta nke HPMC na-abawanye. Na elu dị elu, ụmụ irighiri akwara HPMC na-emekọrịta ihe nke ukwuu na ibe ha, na-eduga na nguzogide dị elu.

Molecular nke hpmc: Viscosity nke hpmc edozighika nke ọma na oke molecular nke polymen. Uzo di elu di elu molecular di elu molecular na-eme ka otutu uzo vita. Nke a bụ n'ihi na ụmụ irighiri polymer na-eme ka nguzogide guzosie ike karịa ka ha na-enweta mkpọsa na esemokwu ha.

Temperacho: Viaty na-agbadata ka okpomọkụ na-abawanye. Nke a bụ n'ihi na oge dị elu na-ebute mbelata nke ndị agha intermolialar n'etiti nje HPMC, si otú a na -ebelata ike ha iguzogide iru mmiri.

Ọnụego shiee: Viscosity nke HPMC nke Ngwọta bụ Shear Ruta-Dabere, karịsịa na mmiri na-abụghị ndị ọhụrụ, nke bụ ihe a na-ahụkarị polymer. Na ala dị ala, ngwọta HPMC na-egosi viscosity dị elu, ebe na ọnụego shiee, vissese ọnụ na-ebelata n'ihi ịkwalite akparamagwa.

Mmetụta nke ike ionic: Ọnụnọ electrolytes (dịka nnu) na ngwọta nwere ike ịgbanwe viscosise. Sanusfọdụ nnu nwere ike ihuenyo ndị na-eme ihe na-aga n'etiti polymer n'agba, na-eme ka ha chịkọta ma na-ebute mbenarị na viscosity.

3. Viscosity vs. Inta anya: nyocha nyocha

A na-ahụkarị usoro izugbe dị na nnwale bụ na viscosity nke hpmc a ngwọta na-abawanye na-abawanye na ịba ụba polymen itinye uche. Mmekọrịta dị n'etiti viscosity na itinye uche na ntinye uche na-esote, nke a na-ejikarị maka ngwọta polymed polymed:

η = ACN \ ETA = AC ^ nη = ACN

Ebe:

η \ Etaη bụ viscosity

CCC bụ ịta HPMC

AAA na NNN bụ ihe dị iche iche na-adabere n'ụdị HPMC na ọnọdụ nke ihe ngwọta.

Maka mgbakwunye, mmekọrịta ahụ dị n'okpuru, mana dịka ịta ahụhụ na-abawanye, viscosise bilitere, na-egosipụta mmekọrịta dị ukwuu n'etiti polymer.

4. Viscosity vs. molecular ibu

Ibu molecular nke Kimacell®hpmc na-arụ ọrụ dị oke mkpa na njirimara ya. Pocylọ polymers dị elu na-etolite na-ejikarị ndọtị viscous na ala dị ala ma e jiri ya tụnyere akara obere molecular ogo. Viccositions nke ihe ngwọta mere site na HPMC nke dị elu nwere ike ịdị ọtụtụ iwu nke ịdị ukwuu karịa nke ngwọta nke emere site na obere akwara.

Iji maa atụ, ihe ngwọta nke HPMC ya na oke molecular nke 100,000 da ga-egosipụta na viscosity dị elu karịa 50,000 dakwa otu itinye uche.

5. Mmetụta mmetụta okpomọkụ na viscosity

Okpomọkụ nwere mmetụta dị ukwuu na viscosity nke ngwọta HPMC. Mmụba na ọnọdụ okpomọkụ na-eduga na mbenazụlite viscosity. Nke a bụ n'ihi mmegharị ọkụ nke polymer agbụ, nke na-eme ka ha kwaga n'efu, belata nguzogide ha na-eru. Mmetụta nke okpomọkụ na viscosis na-ejikarị nha nha anya:

(t) = η0eart \ ETA = \ Eta_0 e ^ {\ frac {}} (t) = η0 eartea

Ebe:

(t) \ ETA η (t) bụ viscosity na ụdị TTT

η0 \ Eta_0η0 bụ ihe mbido ihe (viscosis na oke okpomọkụ)

Eae_aa bụ ike mgbali

Rrr bu mmanu mmanu

Ttt bụ okpomọkụ zuru oke

6. Omume Rheological

A na-akọwakarị Rhimc A na-akọwakarị ihe ngwọta dị ka ndị na-abụghị ndị Newtontian, nke pụtara viscits nke ihe ngwọta anaghị agbanwe agbanwe ma na -aga ya na-etinye ọnụego ya. Na ala Shear, ihe ngwọta HPMC na-egosi ụdị vish nọnyere n'ihi nhata nke polymer agbụ. Agbanyeghị, dị ka ọnụego shoa na-abawanye, viscosisse na-ebelata - ihe dị ịtụnanya dị ka shiee thinning.

Omume a na-ewu ewu bụ ihe a na-ahụkarị nke ọtụtụ ngwọta polymer, gụnyere HPMC. Enwere ike ịkọwa ọnụego ọnụego nke viscosity nke viscosity site na iji ihe nlere-anya:

(γ ·) = KΓ- 1 \ ETA {\ Gamma}) = k \ dot {\ gamma} {}} (γ ·) = kγ˙ n-1

Ebe:

О\ Dot {\ Gamma}

KKK bụ Index Index

nnn bu ihe eji eme ihe omume (na n <1n <1 <1 maka shieer finer)

7. Vieocosis nke HPMC Ngwọta: Nchịkọta tebụl

N'okpuru ebe a bụ tebụl na-achịkọta njirimara viscosit nke HPMC Asquequeons HPMC As n'okpuru ọnọdụ dị iche iche:

Njirimara viscosits nkeHpmcA na-emetụta usoro ihe ngwọta nke ọtụtụ ihe, gụnyere itinye uche, oke molecular, okpomọkụ, na ọnụego ya. HPMC bụ ihe dị iche iche na-adịghị na ya, enwere ike ịhazi ihe ndị na-egbu ya maka ngwa maka ngwa ndị akọwapụtara site na ịgbanwe paramita ndị a. Ghọta ihe ndị a na-enye ohere maka iji kacha mma iji Kimacell®hpmc na ụlọ ọrụ dị iche iche, site na ọgwụ na nri na ịchọ mma. Site na ijikọ ọnọdụ ndị HPMC, ndị na-emepụta nwere ike nweta ụdị viscoside na akụrụngwa na-achọ ịchọrọ maka mkpa ha.