HPMC maka mkpuchi ihe nkiri

HPMC makaIhe mkpuchi ihe nkiri bụ usoro nke ịmepụta ihe nkiri dị mkpa nke polymer n'elu nkwadebe siri ike. Dị ka ihe atụ, a oyi akwa nke ike polymer ihe na-fesa uniformly n'elu larịị nke mpempe akwụkwọ site spraying usoro na-etolite a plastic film oyi akwa ọtụtụ microns oké, nke mere iji nweta ihe a chọrọ. Nhazi nke ihe nkiri a n'èzí mbadamba nkume bụ na otu mbadamba nkume na-akwado ihe mkpuchi polymer mgbe ọ gafesịrị ebe a na-agba mmiri, wee na-enweta akụkụ ọzọ nke ihe mkpuchi mgbe ihichachara. Mgbe adhesion na ihicha ugboro ugboro, a na-emecha ihe mkpuchi ahụ ruo mgbe a ga-ekpuchi elu niile nke nkwadebe ahụ. Ihe mkpuchi ihe nkiri bụ ihe nkiri na-aga n'ihu, ọkpụrụkpụ na-adịkarị n'etiti 8 ruo 100 microns, ogo ụfọdụ nke elasticity na mgbanwe, jigidesie ike na elu nke isi.

N'afọ 1954, Abbott mepụtara mpempe akwụkwọ mbụ nke ihe nkiri na-ere ahịa, ebe ọ bụ na mgbe ahụ, na-aga n'ihu na nkwalite na izu okè nke mmepụta ngwá ọrụ na nkà na ụzụ, polymer ihe nkiri e wepụtara, nke mere na ihe nkiri mkpuchi e mepụtara ngwa ngwa. Ọ bụghị naanị na ụdị dị iche iche, ọnụ ọgụgụ na àgwà nke ndị na-ahụ maka mkpuchi agba amụbawo ngwa ngwa, kamakwa ụdị, ụdị na njirimara nke teknụzụ mkpuchi, ihe mkpuchi na ihe nkiri mkpuchi yana mkpuchi nke ọgwụ TCM ka emepụtara nke ọma. Ya mere, ngwa nke teknụzụ mkpuchi ihe nkiri aghọwo mkpa na mmepe mmepe nke ụlọ ọrụ ọgwụ iji meziwanye àgwà ngwaahịa.

N'oge mbụ na fim mkpuchi ihe nkiri akpụ ihe, a ka nwere ọnụ ọgụgụ buru ibu nke ngwaahịa na-eji HPMChydroxypropyl methylcellulosedị ka Membrane ihe. Ọ bụ ime ka ọ dị ọchaHPMCcellulose sitere na lint owu ma ọ bụ pulp osisi, na ngwọta sodium hydroxide iji gosipụta ọzịza nke cellulose alkali, wee jiri ọgwụgwọ chloromethane na propylene oxide nweta methyl hydroxypropyl cellulose ether.HPMC, ngwaahịa iji wepụ ihe ndị na-adịghị ọcha mgbe ihicha, nchikota, nkwakọ. N'ozuzu, obere viscosity HPMC na-eji dị kaihe nkirimkpuchi ihe, na 2% ~ 10% ngwọta na-eji dị ka mkpuchi ihe ngwọta. Ihe ọghọm bụ na viscosity dị oke ibu yana mgbasawanye siri ike.

Ọgbọ nke abụọ nke ihe na-emepụta ihe nkiri bụ mmanya polyvinyl (PVA). A na-emepụta mmanya polyvinyl site na alcoholysis nke polyvinyl acetate. Enweghị ike iji nkeji ugboro ugboro mmanya Vinyl dị ka ndị na-emeghachi omume n'ihi na ha emezughị oke na ịdị ọcha achọrọ maka polymerization. Na methanol, ethanol ma ọ bụ ethanol na methyl acetate ngwakọta ngwọta na alkali metal ma ọ bụ inorganic acid dị ka ihe na-akpata, hydrolysis bụ ngwa ngwa.

A na-ejikarị PVA eme ihe na mkpuchi ihe nkiri. N'ihi na ọ naghị edozi ya na mmiri n'ime ụlọ okpomọkụ, a na-ekpuchi ya na ihe dịka 20% mgbasa mmiri. Uzuoku mmiri na ikuku oxygen nke PVA dị ala karịa HPMC na EC, yabụ ike igbochi ikuku mmiri na ikuku oxygen siri ike, nke nwere ike ichebe isi mgbawa.

Plasticizer na-ezo aka na ihe nwere ike ịbawanye plasticity nke ihe na-emepụta ihe nkiri. Ụfọdụ ihe na-emepụta ihe nkiri na-agbanwe ọdịdị anụ ahụ ha mgbe okpomọkụ belatara, na mmegharị nke macromolecules ha na-adị ntakịrị, na-eme ka mkpuchi ahụ sie ike ma na-agbaji, na-enweghị ike mgbanwe dị mkpa, ma si otú ahụ dị mfe imebi. Agbakwunyere plasticizer iji belata okpomọkụ mgbanwe iko (Tg) na ịbawanye mgbanwe mkpuchi. Plasticizers ndị a na-ejikarị eme ihe bụ polymers amorphous nwere nnukwu ibu molekụla yana njikọ siri ike na ihe ndị na-emepụta ihe nkiri. Onye na-emepụta ihe na-adịghị edozi ahụ na-enyere aka belata nkwụsị nke mkpuchi ahụ, si otú ahụ na-abawanye nkwụsi ike nke nkwadebe.

A na-ekwenyekarị na usoro nke plasticizer bụ na molekul plasticizer na-etinye n'ime ụdọ polymer, nke na-egbochi mmekọrịta dị n'etiti mkpụrụ ndụ polymer ruo n'ókè dị ukwuu. Mmekọrịta dị mfe mgbe mmekọrịta polymer-plasticizer siri ike karịa mmekọrịta polymer-plasticizer. Ya mere, ohere maka akụkụ polymer ịkwaga na-abawanye.

Ọgbọ nke atọ nke ihe na-emepụta ihe nkiri bụ plasticizer site na usoro kemịkal anyadokwa na fim akpụ ihe polymer

Dịka ọmụmaatụ, ihe nkiri ọhụrụ na-emepụta ihe Kollicoat® IR nke BASF webatara bụ na PEG na-anyado ya na ogologo ogologo nke PVA polymer na-agbakwunyeghị plasticizer, yabụ na ọ nwere ike zere ịkwaga ọdọ mmiri mgbe mkpuchi gasịrị.