Ewebata
Hydroxypropyl methylcellulose, nke a na-akpọkarị HPMC, bụ polymer soluble mmiri nke a na-ejikarị na nkà mmụta ọgwụ, ihe ịchọ mma, nri na ụlọ ọrụ ndị ọzọ. Enwere ike iji HPMC dị ka thickener, ihe nkedo, emulsifier na stabilizer.
1. Họrọ ọkwa kwesịrị ekwesị nke HPMC
The solubility nke HPMC na-adabere na molekụla arọ ya, ogo nke nnọchi, na urughuru nha. Ịhọrọ ọkwa ziri ezi nke HPMC dị mkpa iji hụ na ọ dị mma solubility na ngwa ngwa.
Ọmụmaatụ, obere molekul arọ HPMC nwere mma solubility na mmiri na organic solvents karịa elu molekụla arọ HPMC. Otú ọ dị, elu molekụla arọ HPMC nwere mma film-akpụ Njirimara, nke na-eme ka ọ dabara maka mbadamba mkpuchi.
N'otu aka ahụ, HPMC nwere ogo dị elu nke nnọchi na-agbaze na mmiri karịa HPMC nwere ogo dị ala. A na-ejikarị HPMC nwere ngbanwe dị ala mee ihe n'ụdị ntọhapụ na-adịgide adịgide n'ihi na ọ na-etolite matriks kwụsiri ike na oke.
The urughuru size nke HPMC na-emetụta ya solubility. Ihe dị mma HPMC na-agbaze ngwa ngwa karịa irighiri irighiri ahụ. Ya mere, ọ dị mkpa ka họrọ ziri ezi urughuru HPMC maka otu ngwa.
2. Jiri ihe mgbaze ziri ezi
The solubility nke HPMC na-adabere na ọdịdị nke ihe mgbaze. HPMC na-agbaze na mmiri yana ụfọdụ ihe mgbaze organic, dị ka ethanol, methanol, na mmanya isopropyl. Otú ọ dị, solubility nke HPMC na organic solvents na-adabere na ya polarity.
Mmiri bụ ihe mgbaze a na-ejikarị eme ihe maka HPMC n'ihi na ọ naghị egbu egbu, dị ọnụ ala ma dịkwa ngwa ngwa. Enwere ike ịkwalite solubility nke HPMC na mmiri site na ịgbakwunye nnu ma ọ bụ imezi pH.
Ụlọ ọrụ na-emepụta ọgwụ na-ejikarị ihe mgbaze organic dị ka ethanol, methanol, na mmanya isopropyl na-agbaze HPMC n'ụdị dị ka mbadamba nkume, capsules, na ngwọta ọnụ. Agbanyeghị, enwere ike ịnwe ụfọdụ ọghọm dị na iji ihe mgbaze organic, dị ka nsi, ire ọkụ, na nchegbu gburugburu ebe obibi.
3. Usoro mgbasa ozi kwesịrị ekwesị
Usoro nke ịgbasa HPMC na ihe mgbaze na-emetụtakwa ya solubility. Ụzọ a na-ahụkarị maka ịgbasa HPMC bụ mmiri granulation, nke a na-agwakọta HPMC na ihe ndị ọzọ na-emepụta ihe na ihe mgbaze ka a na-etinye ya ka ọ bụrụ mado. A na-asacha pasta ahụ ma sie ya iji nweta granules.
Otú ọ dị, usoro granulation mmiri na-ekwesịghị ekwesị nwere ike ịkpata adịghị ike solubility na solubility nke HPMC na ngwaahịa ikpeazụ. Ya mere, ọ dị mkpa iji usoro granulation mmiri kwesịrị ekwesị (dịka ọmụmaatụ, ngwakọta kwesịrị ekwesị, ihicha, na sieving) iji nweta granules nke nha na njupụta kwesịrị ekwesị.
Ụzọ ọzọ nke HPMC mgbasa bụ akọrọ granulation Usoro, nke HPMC na-agwakọta na ndị ọzọ excipients na abịakọrọ n'ime mbadamba. A na-egweri mbadamba nkume ndị ahụ ma sie ya iji nweta granules. Mgbe ị na-eji ọgwụ ọjọọ eme ihe, a na-ahọrọ granulation akọrọ na e kwesịghị iji ihe mgbaze mee ihe.
4. Ọnọdụ nchekwa
Ọnọdụ nchekwa nke HPMC na-emetụtakwa solubility ya. Ekwesịrị ịchekwa HPMC n'ebe kpọrọ nkụ, dị jụụ na ebe gbara ọchịchịrị iji gbochie mmiri na ikpughe ìhè anyanwụ. Mmiri na-eme ka HPMC zaa, si otú ahụ na-emetụta solubility ya.
Na ngwụcha
Ịhọrọ ọkwa HPMC kwesịrị ekwesị, iji ihe mgbaze kwesịrị ekwesị, teknụzụ mgbasa ozi kwesịrị ekwesị, na ọnọdụ nchekwa kwesịrị ekwesị bụ ihe dị mkpa na-emetụta solubility nke HPMC. Site n'ịtụle ihe ndị a, enwere ike ịkwalite solubility nke HPMC iji nweta àgwà a chọrọ nke ngwaahịa ikpeazụ.
Oge nzipu: Sep-13-2023