He aha ka hypromellose phthalate?

ʻO Hypromellose phthalate (HPMCP) kahi ʻano o ka lāʻau lapaʻau i hoʻohana ʻia i ka hoʻokumu ʻana i nā ʻano o ka waha, ʻoi aku ka nui o ka hana ʻana i nā papa a me nā capsules i uhi ʻia e enteric. Loaʻa ia mai ka cellulose, ʻo ia ka polymer maoli e hoʻokumu i ka ʻāpana o nā paia o nā mea kanu. ʻO ka HPMCP he wai-soluble, anionic polymer i hoʻohana mau ʻia ma ke ʻano he mea hoʻopili enteric ma muli o kāna mau waiwai hana kiʻiʻoniʻoni maikaʻi loa, kūpaʻa, a me ke kūpaʻa ʻana i nā wai ʻōpū.

Ua hoʻokomo mua ʻia ʻo HPMCP i nā makahiki 1970 mua a ua lilo ia i mea hoʻohana nui ʻia e hoʻohana ʻia ma muli o kāna mau waiwai kūʻokoʻa. Hana ʻia ia e ka esterification o ka hypromellose me ka phthalic acid a loaʻa i nā ʻano o nā māka like ʻole, e pili ana i ke kiʻekiʻe o ka phthalation a me ke kaumaha mole o ka polymer. ʻO nā māka hoʻohana maʻamau o HPMCP ʻo ia ka HPMCP-55, HPMCP-50, a me HPMCP-HP-55, he mau degere like ʻole o ka phthalation a kūpono ia no ka hoʻohana ʻana i nā ʻano hana like ʻole.

ʻO ka hana nui o ka HPMCP i loko o nā ʻano lāʻau lapaʻau ʻo ia ka pale ʻana i nā mea hana o ka lāʻau lapaʻau mai ka hoʻohaʻahaʻa ʻana i loko o ke kaiapuni acidic o ka ʻōpū. Ke hoʻokomo ʻia ka papa a i ʻole ka capsule e loaʻa ana i ka HPMCP, e paʻa mau ka uhi i loko o ka ʻōpū ma muli o ka pH haʻahaʻa, akā i ka manawa e hiki ai ke ʻano o ke ʻano i ka wahi alkaline o ka ʻōpū liʻiliʻi, hoʻomaka ka uhi e hoʻoheheʻe a hoʻokuʻu i nā mea hana. ʻO kēia hoʻokuʻu lohi ʻana e kōkua i ka hōʻoia i ka hāʻawi ʻia ʻana o ka lāʻau lapaʻau i ke kahua o ka hana a ʻaʻole i hoʻopilikia ʻia kona maikaʻi e ka waikawa gastric.