ʻO ke ʻano o ka hana ʻana i ka Hydroxypropyl Methyl Cellulose (HPMC)

ʻO ka Hydroxypropyl methyl cellulose (HPMC) he cellulose ether i hoʻohana nui ʻia i nā ʻano hana ʻenehana a me nā lāʻau lapaʻau ma muli o kāna mau waiwai kino a me nā kemika. Hana ʻia ʻo HPMC ma o nā ʻano hana like ʻole, me ke ʻano hana hana wai-phase.

ʻO ke kaʻina hana hoʻoheheʻe wai he kaʻina hana kemika e pili ana i ka hopena o ka methyl cellulose (MC) me ka propylene oxide (PO) a laila me ka propylene glycol (PG) ma lalo o kekahi mau kūlana. ʻO ke kaʻina hana e pili ana i kēia mau ʻanuʻu:

1. Hoʻomākaukau no ka Methyl Cellulose (MC)

Loaʻa ka MC ma ka mālama ʻana i ka cellulose me ka alkali a laila methylating me ka methyl chloride. Hoʻoholo ka degere o ka hoʻololi ʻana (DS) o MC i kona mau waiwai a hiki ke hoʻomalu ʻia ma ka hoʻololi ʻana i nā kūlana pane.

2. Hoʻomākaukau no ka Propylene Oxide (PO)

Hoʻomākaukau ʻia ʻo PO e ka hoʻoheheʻe ʻana o propylene me ka hoʻohana ʻana i ka ea a i ʻole ka oxygen i mua o kahi catalyst. Hoʻokō ʻia ka hopena ma nā wela kiʻekiʻe a me nā kaomi e hōʻoia i ka hua kiʻekiʻe o PO.

3. Ka pane o MC me PO

Hoʻokō ʻia ka hopena o MC me PO ma ke alo o kahi catalyst a me kahi mea hoʻoheheʻe e like me toluene a i ʻole dichloromethane. He exothermic ka hopena a hoʻoulu i ka wela, pono e mālama ʻia e pale aku i nā hopena holo.

4. Hoʻomākaukau no ka Propylene Glycol (PG)

Hoʻomākaukau ʻia ʻo PG e ka hydrolysis o propylene oxide me ka hoʻohana ʻana i ka wai a i ʻole ka waikawa kūpono a i ʻole ka base catalyst. Hana ʻia ka hopena ma lalo o nā kūlana haʻahaʻa e loaʻa ai kahi hua kiʻekiʻe o PG.

5. Ka pane o MC-PO me PG

Hoʻopili ʻia ka huahana MC-PO me PG i mua o kahi catalyst a me kahi mea hoʻoheheʻe e like me ka ethanol a i ʻole ka methanol. He exothermic hoʻi ka hopena a hoʻohua i ka wela, pono e mālama ʻia e pale i nā hopena holo.

6. Holoi a hoʻomaloʻo

Ma hope o ka hopena, holoi ʻia ka huahana me ka wai a maloʻo no ka loaʻa ʻana o ka HPMC. Hoʻomaʻemaʻe pinepine ʻia ka huahana me ka hoʻohana ʻana i kahi ʻano kānana a me nā ʻanuʻu centrifugation e wehe i nā haumia.

ʻO ke ʻano hana hana wai-wai he nui nā mea maikaʻi ma mua o nā ʻano hana ʻē aʻe, e komo pū me ka hua kiʻekiʻe, ke kumu kūʻai haʻahaʻa, a me ka scalability maʻalahi. Hiki ke hoʻokō ʻia ka hopena i loko o kahi moku hoʻokahi, e hōʻemi ana i ka pono o nā mea paʻakikī a me nā kaʻina hana.

Eia nō naʻe, ʻo ke ʻano hana hana wai-phase kekahi mau drawbacks. Hiki i ka hopena ke hoʻoulu i ka wela, pono e mālama pono ʻia e pale i nā pilikia palekana. Hiki i ka hoʻohana ʻana i nā mea hoʻoheheʻe ke hoʻopilikia i ke kaiapuni a me ke olakino, a ʻo ke kaʻina hana hoʻomaʻemaʻe hiki ke lilo i ka manawa a me ke kumu kūʻai.

I ka hopena, ʻo ke kaʻina hana wai-phase kahi ala i hoʻohana nui ʻia no ka hana ʻana i ka HPMC. ʻO ke ala e pili ana i ka hopena o MC me PO a me PG ma lalo o kekahi mau kūlana, ukali ʻia e ka hoʻomaʻemaʻe a me ka maloʻo. ʻOiai he mau hemahema ke ala, ʻo kāna mau mea maikaʻi e lilo ia i koho kaulana no nā noi ʻoihana a me nā lāʻau lapaʻau.