ʻO ka Hydroxypropyl methyl cellulose HPMC he ʻano o ka non-ionic cellulose i hui ʻia eter, ʻokoʻa ia mai ka ionic methyl carboxymethyl cellulose i hui pū ʻia, ʻaʻole ia e hoʻopili me nā metala kaumaha. Ma muli o nā ʻano like ʻole o ka methoxyl content a me ka hydroxypropyl content i ka hydroxypropyl methylcellulose a me nā viscosities like ʻole, ua lilo ia i nā ʻano ʻano like ʻole me nā waiwai like ʻole, no ka laʻana, kiʻekiʻe methoxyl content a me ka haʻahaʻa hydroxypropyl content ʻO kāna hana kokoke i ka methyl cellulose, a nā ʻano me ka haʻahaʻa methoxyl content a me ka hydroxypropyl content kiʻekiʻe, ua kokoke kāna hana i ka hydroxypropyl methylcellulose. Eia nō naʻe, i loko o nā ʻano like ʻole, ʻoiai he liʻiliʻi wale nō o ka hui hydroxypropyl a i ʻole kahi pūʻulu methoxy liʻiliʻi i loaʻa, ʻokoʻa loa ka solubility i nā solvents organik a i ʻole ka mahana o ka flocculation i loko o ka wai.
1. Ka solubility o ka hydroxypropyl methylcellulose
①Solubility o hydroxypropyl methyl cellulose i loko o ka wai ʻO Hydroxypropyl methyl cellulose he methyl cellulose maoli nō ia i hoʻololi ʻia e propylene oxide (methyl oxypropylene), no laila ua mau nā waiwai like me ka methyl cellulose. Ua like ka cellulose i ka wai anuanu a me ka wai wela. Eia naʻe, ma muli o ka pūʻulu hydroxypropyl i hoʻololi ʻia, ʻoi aku ka kiʻekiʻe o ka mahana gelation i ka wai wela ma mua o ka methyl cellulose. No ka laʻana, ʻo ka viscosity o ka wai wai o hydroxypropyl methylcellulose me 2% methoxyl content DS=0.73 a me ka hydroxypropyl content MS=0.46 he 500 mpa?s ma 20°C. ʻO kona mahana gel Hiki iā ia ke kokoke kokoke i 100 ° C, ʻoiai ʻo methylcellulose i ka mahana like ma kahi o 55 ° C wale nō. No kona hikiwawe i ka wai, ua hoʻomaikaʻi nui ʻia. No ka laʻana, hiki ke hoʻohana i ka pulverized hydroxypropyl methylcellulose (granular shape o 0.2 ~ 0.5mm ma 20 ° C me ka viscosity o 4% aqueous solution a hiki i 2pa?s hiki ke hoʻohana i loko Ma ka lumi wela, hiki ke hoʻoheheʻe ʻia i loko o ka wai me ka ʻole o ka hoʻoluʻu.
②Ka hoʻoheheʻe ʻia o ka hydroxypropyl methyl cellulose i loko o nā mea hoʻoheheʻe organik ʻO ka solubility o ka hydroxypropyl methyl cellulose i loko o nā mea hoʻoheheʻe organik ʻoi aku ka maikaʻi ma mua o ka methyl cellulose, a pono e loaʻa i ka methyl cellulose kahi degere o ka methoxyl substitution ma nā huahana ma luna o 2.1, a me ka hydroxypropyl kiʻekiʻe i loko o ka methylcellulose. hydroxypropyl MS = 1.5 ~ 1.8 a me ka methoxy DS = 0.2 ~ 1.0, a me ka nui o ka hoʻololi degere ma luna o 1.8 hiki ke hoʻoheheʻe ʻia i ka anhydrous methanol a me ka ethanol solutions medium, thermoplastic a me ka wai-soluble. Hiki ke hoʻoheheʻe ʻia i loko o nā hydrocarbons chlorinated e like me ka dichloromethane a me ka chloroform, a me nā mea hoʻoheheʻe kūlohelohe e like me ka acetone, isopropanol a me ka waiʻona diacetone. ʻOi aku ka maikaʻi o kona hoʻoheheʻe ʻana i nā mea hoʻoheheʻe organik ma mua o ka wai.
2. Nā mea e pili ana i ka viscosity o ka hydroxypropyl methylcellulose
ʻO nā kumu hoʻololi o ka hydroxypropyl methyl cellulose viscosity ʻO ka hoʻoholo ʻana i ka viscosity maʻamau o ka hydroxypropyl methyl cellulose, e like me nā cellulose ethers ʻē aʻe, ua hoʻokumu ʻia ma ka 2% aqueous solution ma 20°C. Hoʻonui ka viscosity o ka huahana like me ka piʻi ʻana o ka ʻike. No nā huahana me nā kaumaha molekala like ʻole i ka ʻike like, ʻoi aku ka kiʻekiʻe o ka viscosity o nā huahana me nā kaupaona molekala nui. Ua like kona pilina me ka wela me ka methyl cellulose. Ke piʻi ka mahana, hoʻomaka ka viscosity e emi, akā i ka hiki ʻana i kahi mahana, piʻi koke ka viscosity a puka ka gelation. ʻOi aku ka kiʻekiʻe o ka mahana gel o nā huahana haʻahaʻa-viscosity. kiʻekiʻe. ʻAʻole pili wale kona wahi gel i ka viscosity o ka ether, akā i ka ratio haku mele o ka methoxy a me ka hydroxypropyl i ka ether a me ka huina o ka hoʻololi. Pono e hoʻomaopopo ʻia he pseudoplastic nō hoʻi ka hydroxypropyl methylcellulose a paʻa kona hopena i ka mahana o ka lumi me ka ʻole o ka degradation o ka viscosity koe wale nō ka hiki o ka enzymatic degradation.
3. Hydroxypropyl methylcellulose acid a me ke kūpaʻa alkali
ʻO ka hydroxypropyl methylcellulose acid a me ke kūpaʻa alkali ʻO ka Hydroxypropyl methylcellulose maʻamau ka paʻa i ka waikawa a me ka alkali, a ʻaʻole pili i ka pae o ka pH 2 ~ 12. Hiki iā ia ke pale i kekahi nui o ka waika māmā. E like me formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, etc. Eia naʻe, ʻo ka waikawa concentrated ka hopena o ka hōʻemi ʻana i ka viscosity. ʻAʻohe hopena o ka alkali e like me ka soda caustic, caustic potash a me ka wai lime, akā hiki ke hoʻonui iki i ka viscosity o ka hopena, a laila aia kahi hanana o ka emi ʻana o ka lohi i ka wā e hiki mai ana.
4. Mixability o ka hydroxypropyl methylcellulose
Hiki ke hoʻohuihui ʻia ka hopena o ka Hydroxypropyl Methyl Cellulose Hydroxypropyl methyl cellulose me ka wai-soluble polymer compound e lilo i ʻano like ʻole a ʻākala me ka viscosity kiʻekiʻe. ʻO kēia mau pūhui polymer ka polyethylene glycol, polyvinyl acetate, polysiloxane, polymethyl vinyl siloxane, hydroxyethyl cellulose a me methyl cellulose. ʻO nā pūhui polymer kūlohelohe e like me ka gum arabic, ka ʻūhini ʻūhini, ka karaya gum, a me nā mea ʻē aʻe he maikaʻi ke hui pū ʻana me kāna hopena. Hiki ke hui pū ʻia ka Hydroxypropyl methylcellulose me ka mannitol a i ʻole sorbitol esters o stearic acid a i ʻole palmitic acid, a hiki ke hui pū ʻia me ka glycerin, sorbitol a me ka mannitol. Hiki ke hoʻohana ʻia kēia mau pūhui e like me ka hydroxypropyl methylcellulose. ʻO ka plasticizer ma muli o ka cellulose.
5. ʻO ka hikiʻole a me ka hoʻoheheʻe wai o ka hydroxypropyl methylcellulose
Hiki ke hoʻopili ʻia nā etera cellulose hiki ke hoʻoheheʻe ʻia i ka wai o ka hydroxypropyl methylcellulose me nā aldehydes, a ua hoʻoheheʻe ʻia kēia mau eter hiki ke hoʻoheheʻe ʻia i ka wai i loko o ka hopena a lilo i mea hiki ʻole ke hoʻoheheʻe ʻia i ka wai. ʻO nā aldehydes e hana ai i ka hydroxypropyl methylcellulose insoluble he formaldehyde, glyoxal, succinaldehyde, adipaldehyde, a me nā mea ʻē aʻe. Ke hoʻohana ʻia ka formaldehyde, pono e uku nui ʻia i ka waiwai pH o ka hopena, a ma waena o ka glyoxal e hana wikiwiki ai. No laila, hoʻohana pinepine ʻia ka glyoxal ma ke ʻano he crosslinking agent i ka hana ʻoihana. ʻO ke ʻano o kēia ʻano o ka crosslinking agent i loko o ka hopena he 0.2% ~ 10% o ka ether mass, ʻoi aku ka maikaʻi o 7% ~ 10%, a ʻo 3.3% ~ 6% ka mea kūpono loa no ka glyoxal. ʻO ka mahana mālama maʻamau he 0 ~ 30 ℃, a ʻo ka manawa he 1 ~ 120min. Pono e hoʻokō ʻia ka hopena hoʻopili keʻa ma lalo o nā kūlana acidic. ʻO ka maʻamau, hoʻohui ʻia ka waika ikaika inorganic a i ʻole ka waikawa carboxylic organik i ka hopena e hoʻoponopono ai i ka pH o ka hopena ma kahi o 2 ~ 6, ʻoi aku ka maikaʻi ma waena o 4 ~ 6, a laila hoʻohui ʻia nā aldehydes e hoʻokō i ka hopena cross-linking. . ʻO nā ʻakika i hoʻohana ʻia he waika hydrochloric, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxyacetic acid, succinic acid a i ʻole citric acid, ma waena o ka waika formic a i ʻole acetic acid ka mea kūpono, a ʻo ka formic acid ka mea maikaʻi loa. Hiki ke hoʻohui pū ʻia ka ʻakika a me ka aldehyde i ka manawa like e ʻae i ka hoʻonā e hoʻopili i ka pae pH i makemake ʻia. Hoʻohana pinepine ʻia kēia hopena i ka hana hope loa i ka hoʻomākaukau ʻana o ka cellulose ethers. Ma hope o ka hoʻoheheʻe ʻia o ka cellulose ether, pono e holoi a hoʻomaʻemaʻe me ka wai ma 20 ~ 25 ° C. Ke hoʻohana ʻia ka huahana, hiki ke hoʻohui ʻia kahi mea alkaline i ka hopena o ka huahana e hoʻoponopono i ka pH o ka hopena i alkaline, a e hoʻoheheʻe koke ka huahana i ka hopena. Hoʻopili pū ʻia kēia ʻano hana i ka solution cellulose ether i hana ʻia i kahi kiʻiʻoniʻoni a laila hana ʻia ke kiʻiʻoniʻoni e hana i kahi kiʻiʻoniʻoni insoluble.
6. He kū'ē ka Hydroxypropyl methylcellulose i nā enzymes
He kū'ē ka Hydroxypropyl methylcellulose i nā enzymes. I ke kumumanaʻo, nā derivatives cellulose, e like me kēlā me kēia hui anhydroglucose, he pūʻulu substituent paʻa paʻa, ʻaʻole maʻalahi e hoʻopili ʻia e nā microorganisms, akā ʻoiaʻiʻo ka huahana i hoʻopau ʻia Ke ʻoi aku ka waiwai o ka hoʻololi ʻana i ka 1, e hoʻohaʻahaʻa ʻia hoʻi e nā enzymes, 'o ia ho'i, 'a'ole lawa ka 'oko'a o ka ho'ololi 'ana o kēlā me kēia pū'ulu ma ke kaulahao cellulose, a hiki i nā microorganisms ke ho'opau kokoke i nā pū'ulu anhydroglucose i ho'ololi 'ole e hana i nā kō. , i hoʻomoʻa ʻia ma ke ʻano he meaʻai no nā microorganisms. No laila, inā piʻi ka etherification substitution degere o cellulose, hoʻonui pū ʻia ke kū'ē i ka erosion enzymatic o cellulose ether. Ua hōʻike ʻia ʻo ke koena o ka viscosity o hydroxypropyl methylcellulose (DS=1.9) he 13.2%, methylcellulose (DS=1.83) he 7.3%, a he 3.8% ka methylcellulose (DS=1.66), a he 1.7% ka hydroxyethyl cellulose. Hiki ke ʻike ʻia ka ikaika anti-enzyme o hydroxypropyl methylcellulose. No laila, ʻo ke kūpaʻa enzyme maikaʻi loa o ka hydroxypropyl methylcellulose, i hui pū ʻia me kona dispersibility maikaʻi, ka mānoanoa a me nā waiwai hana kiʻiʻoniʻoni, hoʻohana maʻamau i nā uhi wai-emulsion, etc., a ʻaʻole pono e hoʻohui i nā preservatives. Eia nō naʻe, no ka mālama lōʻihi o ka hopena a i ʻole ka hoʻohaumia ʻana o ka honua i waho, hiki ke hoʻohui ʻia nā preservatives i mea e mālama ai, a hiki ke hoʻoholo ʻia ke koho e like me nā koi hope o ka hopena. ʻO ka Phenylmercuric acetate a me ka manganese fluorosilicate he mau mea mālama pono, akā loaʻa iā lākou ʻelua Toxicity, pono e uku ʻia ka nānā ʻana i ka hana, a ʻo ke ʻano maʻamau ʻo 1 ~ 5mg o ka phenylmercuric acetate i ka lita o ka hopena.
7. Nā waiwai o ka hydroxypropyl methylcellulose film
ʻO ka hana ʻana o ka hydroxypropyl methylcellulose film Hydroxypropyl methylcellulose he mau waiwai hana kiʻiʻoniʻoni maikaʻi loa, a ua uhi ʻia kāna ʻano wai a i ʻole ka mea hoʻoheheʻe organik ma luna o kahi pā aniani, a lilo ia i kala ʻole a ʻike ʻia ma hope o ka maloʻo ʻana. A kiʻiʻoniʻoni paʻakikī. He kūpaʻa maikaʻi kona maʻamau a paʻa mau i nā wela kiʻekiʻe. No ka laʻana, hiki i ka hoʻohui ʻana i kahi plasticizer hygroscopic hiki ke hoʻonui i kona elongation a me ka maʻalahi. No ka hoʻomaikaʻi ʻana i ka maʻalahi, ʻoi aku ka maikaʻi o nā plasticizers e like me glycerin a me sorbitol. ʻO ka hoʻonā hopena maʻamau he 2% ~ 3%, a ʻo ka nui o ka plasticizer he 10% ~ 20% o cellulose ether. Inā kiʻekiʻe loa ka ʻike o ka plasticizer, e kū mai ke ʻano shrinkage o ka colloid dehydration ma lalo o ka haʻahaʻa kiʻekiʻe. ʻOi aku ka nui o ka ikaika tensile o ka kiʻiʻoniʻoni me ka plasticizer i hoʻohui ʻia ma mua o ka mea ʻole me ka plasticizer, a hoʻonui ʻia me ka hoʻonui ʻana o ka nui i hoʻohui ʻia. No ka hygroscopicity o ke kiʻiʻoniʻoni, hoʻonui ia me ka hoʻonui ʻana o ka nui o ka plasticizer.
Ka manawa hoʻouna: Oct-13-2022