ʻO nā mea kōkua lāʻau lapaʻau Cellulose Etera

ʻO ka cellulose ether kūlohelohe kahi huaʻōlelo maʻamau no ke ʻano onā mea hoʻopuka cellulosehana ʻia e ka hopena o ka cellulose alkali a me ka etherifying agent ma lalo o kekahi mau kūlana. He huahana kahi i hoʻololi ʻia ai nā pūʻulu hydroxyl ma nā macromolecules cellulose e nā hui ether. Hoʻohana nui ʻia nā cellulose ethers i nā ʻoihana o ka petroleum, nā mea kūkulu hale, nā uhi, nā meaʻai, nā lāʻau lapaʻau, a me nā kemika i kēlā me kēia lā. Ma nā kula like ʻole, aia nā huahana lāʻau lapaʻau ma waena a me nā kahua kiʻekiʻe o ka ʻoihana, me ka waiwai hoʻohui kiʻekiʻe. Ma muli o nā koi koʻikoʻi koʻikoʻi, paʻakikī hoʻi ka hana ʻana o ka cellulose ether pharmaceutical-grade. Hiki ke ʻōlelo ʻia ʻo ka maikaʻi o nā huahana pharmaceutical-grade hiki ke hōʻike i ka ikaika ʻenehana o nā ʻoihana cellulose ether. Hoʻohui pinepine ʻia ka cellulose ether ma ke ʻano he blocker, mea matrix a me ka mānoanoa e hana i nā papa matrix hoʻokuʻu mau, nā mea hoʻoheheʻe gastric-soluble, nā mea hoʻopaʻa microcapsule hoʻokuʻu paʻa, nā mea kiʻiʻoniʻoni lāʻau hoʻokuʻu mau, etc.

Sodium carboxymethyl cellulose:

ʻO Carboxymethyl cellulose sodium (CMC-Na) ka ʻano cellulose ether me ka hana nui a me ka hoʻohana ʻana ma ka home a ma waho. ʻO ia ka ionic cellulose ether i hana ʻia mai ka pulupulu a me ka lāʻau ma o ka alkalization a me ka etherification me ka chloroacetic acid. ʻO CMC-Na kahi mea hoʻohana lāʻau lapaʻau maʻamau. Hoʻohana pinepine ʻia ʻo ia ma ke ʻano he mea hoʻopaʻa no ka hoʻomākaukau paʻa, kahi mea mānoanoa, kahi mea mānoanoa, a me kahi mea hoʻomaha no ka hoʻomākaukau wai. Hiki ke hoʻohana ʻia ma ke ʻano he matrix hoʻoheheʻe wai a me nā mea hana kiʻiʻoniʻoni. Hoʻohana pinepine ʻia ʻo ia ma ke ʻano he kiʻiʻoniʻoni lāʻau hoʻokuʻu hoʻomau a me ka papa matrix hoʻokuʻu hoʻokuʻu ʻia i nā hoʻomākaukau hoʻokuʻu hoʻomau.

Ma waho aʻe o ka sodium carboxymethylcellulose ma ke ʻano he lāʻau lapaʻau, hiki ke hoʻohana ʻia ka sodium croscarmellose e like me ka excipient lāʻau lapaʻau. ʻO ka sodium Croscarmellose (CCMC-Na) he huahana hiki ʻole ke hoʻoheheʻe ʻia i ka wai o ka carboxymethylcellulose reacting me ka crosslinking agent ma kahi mahana (40-80 ° C) ma lalo o ka hana a kahi mea hoʻoheheʻe waika inorganic a hoʻomaʻemaʻe ʻia. Ma ke ʻano he crosslinking agent, propylene glycol, succinic anhydride, maleic anhydride a me adipic anhydride hiki ke hoʻohana ʻia. Hoʻohana ʻia ka sodium Croscarmellose ma ke ʻano he disintegrant no nā papa, capsules a me nā granules i ka hoʻomākaukau waha. Ke hilinaʻi nei ia i nā hopena capillary a me ka pehu e wāwahi. Loaʻa iā ia ka compressibility maikaʻi a me ka ikaika disintegration ikaika. Ua hōʻike nā haʻawina e ʻoi aku ka nui o ka pehu o ka sodium croscarmellose i loko o ka wai ma mua o nā mea hoʻopau maʻamau e like me ka sodium carmellose haʻahaʻa a me ka cellulose microcrystalline hydrated.

Methylcellulose:

ʻO ka Methyl cellulose (MC) kahi ether non-ionic cellulose i hana ʻia mai ka pulupulu a me ka lāʻau ma o ka alkalization a me ka methyl chloride etherification. Methylcellulose loaʻa ka wai hoʻoheheʻe maikaʻi a paʻa i ka laulā o pH2.0 ~ 13.0. Hoʻohana nui ʻia ia i nā excipients pharmaceutical, a hoʻohana ʻia i nā papa sublingual, intramuscular injections, ophthalmic preparations, waha capsules, oral suspensions, waha papa a me nā hoʻomākaukau topical. Eia kekahi, i ka hoʻomākaukau hoʻokuʻu hoʻomau, hiki ke hoʻohana ʻia ka MC e like me ka hydrophilic gel matrix i hoʻopaʻa ʻia i ka hoʻokuʻu ʻana i ka hoʻomākaukau ʻana, nā mea hoʻoheheʻe gastric-soluble, nā mea hoʻopili microcapsule i hoʻokuʻu ʻia, nā mea kiʻi lāʻau hoʻokuʻu hoʻokuʻu ʻia, etc.

Hydroxypropyl methyl cellulose:

ʻO ka Hydroxypropyl methylcellulose (HPMC) he cellulose non-ionic i hui pū ʻia me ka pulupulu a me ka lāʻau ma o ka alkalization, propylene oxide a me methyl chloride etherification. ʻAʻohe ona, ʻono ʻole, ʻona ʻole, hiki ke hoʻoheheʻe ʻia i ka wai anuanu a gelled i ka wai wela. ʻO Hydroxypropyl methylcellulose kahi ʻano cellulose i hui pū ʻia me ka nui o ka ulu ʻana, ka nui a me ka maikaʻi i Kina i nā makahiki he 15 i hala. ʻO ia kekahi o nā mea hoʻohana lāʻau lapaʻau i hoʻohana nui ʻia ma ka home a ma waho. makahiki o ka moolelo. I kēia manawa, ʻike nui ʻia ka noi ʻana o HPMC ma nā ʻano ʻelima:

ʻO kekahi ma ke ʻano he mea hoʻopaʻa a hoʻopau. Ma ke ʻano he mea hoʻopaʻa, hiki i ka HPMC ke hoʻomaʻemaʻe i ka lāʻau, a hiki iā ia ke hoʻonui i nā haneli mau manawa ma hope o ka lawe ʻana i ka wai, no laila hiki iā ia ke hoʻomaikaʻi nui i ka helu hemo a i ʻole ka hoʻokuʻu ʻana o ka papa. Loaʻa i ka HPMC ka viscosity ikaika, hiki ke hoʻonui i ka viscosity particle a hoʻomaikaʻi i ka hoʻopili ʻana o nā mea maka me ka ʻano crisp a brittle. Hiki ke hoʻohana ʻia ka HPMC me ka viscosity haʻahaʻa e like me ka binder a me ka disintegrant, a ʻo nā mea me ka viscosity kiʻekiʻe hiki ke hoʻohana wale ʻia e like me ka binder.

ʻO ka lua ma ke ʻano he mea hoʻokuʻu paʻa a mālama ʻia no ka hoʻomākaukau waha. ʻO ka HPMC kahi mea maʻamau hydrogel matrix i hoʻomākaukau ʻia i hoʻokuʻu ʻia. Hiki ke hoʻohana ʻia ka HPMC ma ke ʻano he binder, viscosifier a me suspending agent, a me ka high-viscosity grade (4000-100000mPa·s) hiki ke hoʻohana ʻia ka HPMC no ka hoʻomākaukau ʻana i nā mea i hui ʻia. nā papa hoʻokuʻu lōʻihi. Hiki ke hoʻoheheʻe ʻia ka HPMC i ka wai ʻōpū, loaʻa nā pōmaikaʻi o ka compressibility maikaʻi, ka wai maikaʻi, ka hiki ke hoʻouka lāʻau ikaika, a me nā ʻano hoʻokuʻu lāʻau ʻaʻole i hoʻopilikia ʻia e PH. He mea koʻikoʻi nui ka mea lawe hydrophilic i nā ʻōnaehana hoʻomākaukau hoʻokuʻu hoʻomau a hoʻohana pinepine ʻia e like me ka Hydrophilic gel matrix a me nā mea uhi no ka hoʻomākaukau hoʻokuʻu hoʻomau, a me nā mea kōkua no ka hoʻomākaukau ʻana o ka ʻōpū a me nā hoʻomākaukau kiʻi lāʻau hoʻokuʻu mau.

ʻO ke kolu he mea hoʻouhi kiʻiʻoniʻoni. Loaʻa iā HPMC nā waiwai hana kiʻiʻoniʻoni maikaʻi. ʻO ke kiʻiʻoniʻoni i hana ʻia e ia he ʻano like, ʻikea a paʻakikī, a ʻaʻole maʻalahi ke paʻa i ka wā hana. ʻOi loa no nā lāʻau lapaʻau e maʻalahi ke komo i ka makū a paʻa ʻole, me ka hoʻohana ʻana iā ia ma ke ʻano he papa hoʻokaʻawale hiki ke hoʻomaikaʻi nui i ke kūpaʻa o ka lāʻau lapaʻau a pale ʻO ke kiʻiʻoniʻoni e hoʻololi i ke kala. Loaʻa i ka HPMC nā ʻano kikoʻī viscosity. Inā koho pono ʻia, ʻoi aku ka maikaʻi a me ke ʻano o nā papa i uhi ʻia ma mua o nā mea ʻē aʻe. ʻO ka manaʻo maʻamau he 2% a 10%.

ʻO ka hā he mea capsule. I nā makahiki i hala iho nei, me nā maʻi maʻi maʻi holoholona honua, i hoʻohālikelike ʻia me nā capsules gelatin, ua lilo nā capsules meaʻai i mea aloha hou o ka ʻoihana lāʻau a me nā meaʻai. Ua hoʻopuka maikaʻi ʻo Pfizer o ʻAmelika Hui Pū ʻIa i ka HPMC mai nā mea kanu kūlohelohe a hoʻomākaukau i nā capsule mea kanu VcapTM. Hoʻohālikelike ʻia me nā capsules hollow gelatin kuʻuna, loaʻa i nā capsules mea kanu nā mea maikaʻi o ka hiki ke hoʻololi ʻia, ʻaʻohe pilikia o nā hopena cross-linking a me ke kūpaʻa kiʻekiʻe. ʻO ka hoʻokuʻu ʻana o ka lāʻau lapaʻau paʻa, a liʻiliʻi nā ʻokoʻa o kēlā me kēia kanaka. Ma hope o ka hemo ʻana i loko o ke kino o ke kanaka, ʻaʻole i komo a hiki ke hoʻokuʻu ʻia Hoʻokuʻu ʻia ka mea mai ke kino. Ma ke ʻano o ka mālama ʻana, ma hope o ka nui o nā hoʻāʻo, ʻaneʻane ʻaʻole palupalu ia ma lalo o nā kūlana haʻahaʻa haʻahaʻa, a paʻa mau nā waiwai o ka pūpū capsule ma lalo o nā kūlana haʻahaʻa kiʻekiʻe, a ʻaʻole pili nā hōʻailona o nā capsules mea kanu ma lalo o ka mālama nui. kūlana. Me ka hoʻomaopopo ʻana o ka poʻe i nā capsules mea kanu a me ka hoʻololi ʻana o nā manaʻo lāʻau lapaʻau lehulehu ma ka home a ma waho, e ulu wikiwiki ka mākeke no nā capsules mea kanu.

ʻO ka lima ma ke ʻano he mea hoʻomaha. ʻO ka hoʻomākaukau ʻana i ka wai ʻano suspension he ʻano lāʻau lapaʻau maʻamau i hoʻohana ʻia, ʻo ia kahi ʻōnaehana dispersion heterogeneous kahi e hoʻopuehu ʻia ai nā lāʻau paʻa ʻole i loko o kahi ʻano hoʻopuehu wai. Hoʻoholo ka paʻa o ka ʻōnaehana i ka maikaʻi o ka hoʻomākaukau ʻana i ka wai hoʻomaha. Hiki i ka HPMC colloidal solution ke ho'ēmi i ka paʻa-wai interfacial tension, e hoʻemi i ka ikehu manuahi o nā ʻāpana paʻa, a hoʻopaʻa i ka ʻōnaehana heterogeneous dispersion. He lāʻau hoʻomaha maikaʻi loa ia. Hoʻohana ʻia ʻo HPMC ma ke ʻano he mānoanoa no nā kulu maka, me kahi maʻiʻo o 0.45% a 1.0%.

Hydroxypropyl Cellulose:

ʻO ka Hydroxypropyl cellulose (HPC) kahi ether non-ionic cellulose i hana ʻia mai ka pulupulu a me ka lāʻau ma o ka alkalization a me ka propylene oxide etherification. Hiki ke hoʻoheheʻe ʻia ka HPC i ka wai ma lalo o 40 ° C a me ka nui o nā solvents polar, a ua pili kāna hana i ka ʻike o ka hui hydroxypropyl a me ke degere o ka polymerization. Hiki ke hoʻohālikelike ʻia ka HPC me nā lāʻau like ʻole a loaʻa ka inertia maikaʻi.

Hoʻohana nui ʻia ka hydroxypropyl cellulose haʻahaʻa haʻahaʻa (L-HPC) e like me ka disintegrant papa a me ka binder. -HPC hiki ke hoʻonui i ka paʻakikī a me ka'ōlinolino o ka papa, a hiki ke hoʻopau koke i ka papa, hoʻomaikaʻi i ka maikaʻi o loko o ka papa, a hoʻomaikaʻi i ka hopena curative.

Hiki ke hoʻohana ʻia ka hydroxypropyl cellulose (H-HPC) i mea hoʻopili no nā papa, granules, a me nā granules maikaʻi ma ke kahua lāʻau. Loaʻa i ka H-HPC nā waiwai hana kiʻiʻoniʻoni maikaʻi loa, a ʻo ke kiʻi i loaʻa he paʻakikī a elastic, hiki ke hoʻohālikelike ʻia me nā plasticizers. Hiki ke hoʻomaikaʻi hou ʻia ka hana ʻana o ke kiʻiʻoniʻoni ma o ka hui ʻana me nā mea hoʻoheheʻe ʻē aʻe, a ua hoʻohana pinepine ʻia ʻo ia ma ke ʻano he mea uhi kiʻiʻoniʻoni no nā papa. Hiki ke hoʻohana ʻia ʻo H-HPC ma ke ʻano he mea matrix no ka hoʻomākaukau ʻana i nā papa hoʻokuʻu hoʻokuʻu ʻia matrix, nā pellets hoʻokuʻu ʻia a me nā papa hoʻokuʻu hoʻokuʻu pālua.

Hydroxyethyl cellulose

ʻO ka Hydroxyethyl cellulose (HEC) kahi ether non-ionic cellulose i hana ʻia mai ka pulupulu a me ka lāʻau ma o ka alkalization a me ka etherification o ka ethylene oxide. Ma ke kahua o ka lāʻau lapaʻau, hoʻohana nui ʻia ʻo HEC ma ke ʻano he mānoanoa, colloidal protection agent, adhesive, dispersant, stabilizer, suspending agent, film-forming agent a me nā mea hoʻokuʻu paʻa, a hiki ke hoʻopili ʻia i nā emulsions topical, ʻaila, kulu maka, ʻO ka wai waha, ka papa paʻa, ka capsule a me nā ʻano hana ʻē aʻe. Ua hoʻopaʻa ʻia ʻo Hydroxyethyl cellulose i ka US Pharmacopoeia/US National Formulary a me ka European Pharmacopoeia.

Ethyl cellulose:

ʻO Ethyl cellulose (EC) kekahi o nā mea i hoʻohana nui ʻia i ka wai-insoluble cellulose derivatives. ʻAʻole ʻawaʻawa ʻo EC, paʻa, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka wai, ka waikawa a i ʻole ka hopena alkali, a hiki ke hoʻoheheʻe ʻia i nā mea hoʻoheheʻe kūlohelohe e like me ka ethanol a me ka methanol. ʻO ka mea hoʻoheheʻe maʻamau i hoʻohana ʻia ʻo toluene/ethanol ma ke ʻano he 4/1 (kaumaha) i hui pū ʻia. He nui ka hoʻohana ʻana o EC i ka hoʻomākaukau hoʻokuʻu ʻana i ka lāʻau lapaʻau, hoʻohana nui ʻia e like me nā mea lawe, microcapsules, a me ka uhi ʻana i nā mea hana kiʻiʻoniʻoni no ka hoʻomākaukau ʻana i hoʻokuʻu ʻia, e like me nā papa papa, nā mea hoʻopili, a me nā mea hoʻonaninani kiʻiʻoniʻoni, hoʻohana ʻia ma ke ʻano he kiʻiʻoniʻoni matrix e hoʻomākaukau ai. nā ʻano papa like ʻole o ka matrix sustained-release papa, hoʻohana ʻia ma ke ʻano he mea hui e hoʻomākaukau ai i nā mea hoʻomākaukau hoʻokuʻu paʻa i uhi ʻia, nā pellets hoʻokuʻu paʻa, a hoʻohana ʻia ma ke ʻano he mau mea kōkua encapsulation e hoʻomākaukau ai i nā microcapsules hoʻokuʻu mau; hiki ke hoʻohana nui ʻia ma ke ʻano he mea lawe no ka hoʻomākaukau ʻana i nā dispersion paʻa; hoʻohana nui ʻia i ka ʻenehana lāʻau lapaʻau ma ke ʻano he kiʻiʻoniʻoni a me ka uhi pale, a me ka mea hoʻopili a me ka hoʻopiha. Ma keʻano he pale pale o ka papa, hiki iā ia ke hoʻemi i ka naʻau o ka papa i ka haʻahaʻa a pale i ka lāʻau mai ka hoʻopiliʻana i ka wai, ka weheʻana a me ka pōʻino; Hiki iā ia ke hana i kahi papa gel hoʻokuʻu lohi, microencapsulate i ka polymer, a hiki i ka hoʻokuʻu mau ʻana o ka hopena lāʻau.